Therapeutic agent for infectious skin or mucosal disease

A disease treatment and infectious technology, applied in skin diseases, sexual diseases, sensory diseases, etc., can solve problems such as the increase of refractory cases of skin diseases

Active Publication Date: 2010-02-03
TAIKO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the other hand, drug-resistant bacteria have appeared due to the indiscriminate use of antibiotics and antibacterial drugs, and treatment resistance has occurred even with interferon, and the number of refractory cases of skin diseases has gradually increased.

Method used

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  • Therapeutic agent for infectious skin or mucosal disease
  • Therapeutic agent for infectious skin or mucosal disease
  • Therapeutic agent for infectious skin or mucosal disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0028] The drug for treating skin diseases according to the present embodiment contains a chlorine dioxide solution containing dissolved chlorine dioxide gas, chlorite, and a pH adjuster. For example, the chlorite is sodium chlorite, and the pH adjuster is a buffering acid or a salt thereof whose pH of a 5% aqueous solution is 2.5 to 6.8 at 25°C.

[0029] In addition, sodium chlorite may be used as the chlorite, and phosphoric acid or a salt thereof may be used as the pH adjuster.

[0030] Furthermore, the chlorite may be sodium chlorite, and the pH adjuster may be sodium dihydrogen phosphate, or a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate.

[0031] Examples of the chlorite that can be used in the present invention include alkali metal chlorite and alkaline earth metal chlorite. Examples of alkali metal chlorite include sodium chlorite, potassium chlorite, and lithium chlorite, and alkaline earth metal salts of chlorite include calcium chlorite, m...

Embodiment approach 2

[0042] The drug for treating skin diseases according to the present embodiment contains a chlorine dioxide solution containing dissolved chlorine dioxide gas, chlorite, and an acidic surfactant. For example, chlorite is sodium chlorite, and the surfactant showing acidity is a mixed surfactant formed of sucrose fatty acid ester, sodium citrate, propylene glycol, and ethanol.

[0043] When not using a pH adjuster, a surfactant showing acidity (preferably a buffering acid or a salt thereof with a pH of 3.5 to 6.0 in a 5% aqueous solution at 25° C., more preferably a pH of 4.0 to 5.5) can be used.

[0044]The surfactant showing acidity is not particularly limited, and examples thereof include phosphate ester salt-based surfactants (polyoxyethylene phosphate, alkyl phosphate ester salts, etc.), sulfonate-based surfactants (dodecyl Sodium sulfonate, sodium dodecylbenzene sulfonate and other alkyl or alkylbenzene sulfonates, isopropyl naphthalene sulfonate and other alkyl naphthalene...

Embodiment approach 3

[0046] The drug for treating skin diseases according to the present embodiment contains a chlorine dioxide solution containing dissolved chlorine dioxide gas, chlorite, and a pH adjuster, and a superabsorbent resin (gel composition).

[0047] For example, the superabsorbent resin is starch-based absorbent resin, cellulose-based absorbent resin, or synthetic polymer-based absorbent resin; the chlorite is sodium chlorite; the pH adjuster is sodium dihydrogen phosphate, or dihydrogen phosphate; A mixture of sodium hydrogen phosphate and disodium hydrogen phosphate.

[0048] A gel-like composition can be prepared by mixing a chlorine dioxide solution containing dissolved chlorine dioxide gas, chlorite, and a pH adjuster with a superabsorbent resin.

[0049] Examples of superabsorbent resins include starch-based water-absorbent resins (starch-acrylonitrile graft copolymers, starch-acrylic acid graft copolymers, starch-styrenesulfonic acid graft copolymers, starch-vinylsulfonic acid...

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Abstract

A therapeutic agent for infectious skin and mucosal diseases to be applied to an infected area for ameliorating a symptom of the infected area caused by infection with a pathogenic microorganism includes: a chlorine dioxide solution including a dissolved chlorine dioxide gas.

Description

technical field [0001] The present invention relates to the disease treatment medicine (referring to the treatment medicine for infectious skin disease and infectious mucous membrane disease) that is used for improving the symptom of the infection part that comes on because of pathogenic microorganism infection, is applicable to the skin and mucous membrane of described infection part , hereinafter also collectively referred to as "drugs for the treatment of skin diseases"), in detail, relate to refractory skin diseases such as skin diseases caused by human papillomavirus, which contain dissolved chlorine dioxide and have no effective treatment method so far. A medicine that can also cure skin diseases. Background technique [0002] Pathogenic microorganisms that cause skin diseases and skin and mucous membrane diseases through infection, such as human papillomavirus, enter from small wounds in the skin and mucous membranes, not only causing warts (warts) on the fingers (toe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/20A61K33/08A61P11/00A61P15/00A61P17/00A61P27/00A61P31/04A61P31/10A61P31/12A61P1/00
CPCA61K33/00A61K33/20A61K33/42A61K45/06A61P1/00A61P11/00A61P15/00A61P17/00A61P27/00A61P31/00A61P31/02A61P31/04A61P31/10A61P31/12A61P31/22A61K2300/00
Inventor 柴田高
Owner TAIKO PHARMA
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