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Chemical composition separation method of traditional Chinese medicine smilax composition and clinical application thereof

A separation method and technology for chemical components are applied in the field of separation of chemical components of medicinal plants to achieve the effect of simple and easy determination and good reproducibility.

Active Publication Date: 2010-02-17
RONGCHANG PHARM ZIBO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] According to prior art reports, Smilax saponins contain Smilax saponins, Tigogenin and tannins, etc.

Method used

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  • Chemical composition separation method of traditional Chinese medicine smilax composition and clinical application thereof
  • Chemical composition separation method of traditional Chinese medicine smilax composition and clinical application thereof
  • Chemical composition separation method of traditional Chinese medicine smilax composition and clinical application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0099] 1 Reagents and instruments

[0100] Reagent name Manufacturer or specification model

[0101] Methanol (analytical pure) Tianjin Kemiou Chemical Reagent Co., Ltd.

[0102] Chloroform Laiyang Economic and Technological Development Zone Precision Chemical Factory

[0103] Ethyl acetate Yantai Sanhe Chemical Reagent Co., Ltd.

[0104] Cyclohexane Tianjin Fuchen Chemical Reagent Factory

[0105] Anhydrous ethanol Tianjin Fuchen Chemical Reagent Factory

[0106] Petroleum ether Tianjin Fuchen Chemical Reagent Factory

[0107] Glacial acetic acid Sinopharm Chemical Reagent Co., Ltd.

[0108] Methanol (chromatographically pure)

[0109] Instrument name Manufacturer or specification model

[0110] VARIAN type preparative liquid phase American Varian Co., Ltd.

[0111] AVANCE-400 Nuclear Magnetic Resonance Apparatus Bruker, Switzerland

[0112] ZF-I UV Lamp Shanghai Gucun Electro-optical Instrument Factory

[0113] UV-2550 ultraviolet spectrophotometer; Japan Shimadzu ...

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Abstract

The invention relates to a chemical composition separation method of a traditional Chinese medicine smilax composition and a clinical application thereof. The method comprises the preparation of the water extractive extractum of the traditional Chinese medicine smilax composition, the ethyl acetate extraction of the water extractive material of the traditional Chinese medicine smilax composition,and the separation and measurement of the ethyl acetate extract by silicagel column chromatography. By the method, dihydro-kaempferol, dihydro-kaempferol 3-O-alpha-L-rhamnoside, and 3,3,5,5,7-pentahydroxy-flavanone 3-O-alpha-L-rhamnoside can be obtained, wherein the 3,3,5,5,7-pentahydroxy-flavanone 3-O-alpha-L-rhamnoside is separated from the smilax composition for the first time.

Description

technical field [0001] The invention belongs to a method for separating chemical components of medicinal plants, in particular to a method for separating chemical components of a traditional Chinese medicine sarsaparilla composition and its clinical application. Background technique [0002] The smilax composition is mainly prepared from the extract prepared from the Chinese medicinal materials sarsaparilla and smilax smilax through water extraction and alcohol precipitation, and appropriate amount of auxiliary materials. It is mainly used clinically to treat psoriasis; although it has been clinically used for many years and has good curative effect, its drug composition has not been very clear. [0003] Smilax (Smilax china L.) is the rhizome of Smilax genus Smilax in Liliaceae; (Smilax leaves are also used as medicine). [0004] According to prior art reports, Smilax root contains Smilaxin, Isoengeletin, Oleanolic acid, Kaempferide, Dihydrokaempferide, β -Sitosterol (β-S...

Claims

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Application Information

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IPC IPC(8): C07D311/32C07D311/40C07H17/07C07H1/08A61K36/896A61P17/06
Inventor 郭桂秋姜永涛魏金钊徐贝贝郗光建翟勇李钦刚
Owner RONGCHANG PHARM ZIBO CO LTD
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