Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease and preparation process thereof

A technology for bursal disease and chicken Newcastle disease, applied in the direction of antibodies, antiviral agents, allergic diseases, etc., can solve the problems of difficult implementation, difficult clinical wide acceptance, high price, etc., and achieve effective and rapid control effects

Active Publication Date: 2012-06-06
LIAONING YIKANG BIOLOGICAL CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] For example, interferon, cytokines, etc., are difficult to be widely accepted clinically due to their high price, and it is even more difficult to implement them in chicken Newcastle disease-infectious bursal disease

Method used

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  • Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1. Multi-taste traditional Chinese medicine polysaccharide type chicken Newcastle disease-infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation

[0094] 1. Ingredients:

[0095] Anti-Newcastle disease-infectious bursal disease virus egg yolk antibody 99.5 kg;

[0096] Chinese medicine polysaccharide 0.5 kg;

[0097] The traditional Chinese medicine polysaccharide is extracted from the following Chinese medicinal materials in parts by weight: Radix Radix 10, Rehmannia glutinosa 50, Salvia miltiorrhiza 50, and Glycyrrhizae 30.

[0098] 2. Preparation:

[0099] (1) Prepare eggs highly immune to Newcastle disease-infectious bursal disease virus.

[0100] (1.1) Specific pathogen-free laying hens are kept in isolation in clean farms;

[0101] (1.2) Laying hens are immunized 3 times, and each chicken is injected with Newcastle disease-infectious bursal disease vaccine each time, and the injection volume is 0.5ml, 1.5ml and 2.0ml...

Embodiment 2

[0136] Example 2. Three flavors of traditional Chinese medicine polysaccharide type chicken Newcastle disease-infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation

[0137] 1. Ingredients:

[0138] Anti-Newcastle disease-infectious bursal disease virus egg yolk antibody 65 kg;

[0139] Chinese medicine polysaccharide 6 kg;

[0140] 10 kg of sucrose;

[0141] 2. Preparation:

[0142] The preparation method of egg yolk antibody and polysaccharide is the same as that in Example 1, except that the source of polysaccharide extraction is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Radix Radix Radix, 20 parts of Rehmannia glutinosa, and 10 parts of Glycyrrhizae;

[0143] The synthesis process and method of the compound preparation are the same as in Example 1, except that the synthetic raw materials are changed to 65 kilograms of anti-Newcastle disease-infectious bursal disease virus yolk ...

Embodiment 3

[0146] Example 3. Concentrated freeze-dried egg yolk antibody compound preparation of two kinds of traditional Chinese medicine polysaccharide type chicken Newcastle disease-infectious bursal disease

[0147] 1. Ingredients:

[0148] Anti-Newcastle disease-infectious bursal disease virus egg yolk antibody 40 kg;

[0149] Chinese medicine polysaccharide 20 kg;

[0150] Albumin 6 kg;

[0151] 2. Preparation:

[0152] The preparation method of yolk antibody and polysaccharide is the same as in Example 1, except that the extraction source of polysaccharide is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of licorice, 30 parts of salvia miltiorrhiza;

[0153] The synthesis process and method of the compound preparation are the same as in Example 1, except that the synthetic raw materials become 40 kilograms of anti-Newcastle disease-infectious bursal disease virus egg yolk antibody, 20 kilograms of polysaccharides and 6 kilogram...

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Abstract

The invention provides a concentrated freeze-dried yolk antibody composite preparation for Newcastle disease-infectious bursal disease, which contains the following components in part by weight: 10.0 to 99.5 parts of Newcastle disease-infectious bursal disease virus resistant yolk antibody and 0.5 to 20.0 parts of Chinese medicinal polysaccharide, wherein the Chinese medicinal polysaccharide is extracted from one or a composition of more than two of the following Chinese medicines in part by weight: 10 to 50 parts of indigowoad root, 50 to 100 parts of fresh rehmannia, 50 to 80 parts of danshen root and 30 to 50 parts of liquorice. The preparation is a freeze-dried preparation prepared by combining the components such as the Newcastle disease-infectious bursal disease virus resistant yolkantibody and the polysaccharide under the guidance of immunity engineering of Chinese medical science, is clinically used for the Newcastle disease-infectious bursal disease, has the effect of treating the Newcastle disease-infectious bursal disease virus infection, and excites the immunity and disease resistance of organisms; and simultaneously, the polysaccharide component in the preparation has powerful protection effect on the yolk antibody.

Description

technical field [0001] The invention relates to an antibody compound preparation, in particular to a chicken Newcastle disease-infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation and a preparation method thereof. Background technique [0002] Chicken Newcastle disease - infectious bursal disease is the enemy of the chicken industry. Anti-infective drugs currently used in the prevention and treatment of chicken Newcastle disease-infectious bursal disease include antibiotics, chemically synthesized drugs, traditional Chinese medicine and its preparations, hyperimmune egg yolk antibodies and other anti-infective biological agents. [0003] (1) Antibiotics [0004] Such anti-infective drugs are mainly metabolites produced by microorganisms such as bacteria, fungi, and actinomycetes, as well as artificially imitated synthetic or semi-synthetic antibiotics. They have a strong inhibitory or killing effect on pathogenic microorganisms, a wide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61P31/14A61P37/04C08B37/00C07K16/10A61K31/715
Inventor 苗玉和李尚波胥桂华张勇飞赵冰武洁梅
Owner LIAONING YIKANG BIOLOGICAL CORP LTD
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