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Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease and preparation process thereof

A technology of egg yolk antibody and compound preparation, which is applied in the direction of antibody, antiviral agent, drug combination, etc., can solve the problems of high price, difficulty in clinical wide acceptance, difficulty in implementation of Newcastle disease, etc., and achieve effective and rapid control effect

Active Publication Date: 2011-07-27
LIAONING YIKANG BIOLOGICAL CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] For example, interferon, cytokines, etc., are difficult to be widely accepted clinically due to their high price, and it is even more difficult to implement them in the treatment of chicken Newcastle disease

Method used

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  • Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for Newcastle disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1. Multi-taste traditional Chinese medicine polysaccharide type chicken Newcastle disease concentrated freeze-dried egg yolk antibody compound preparation

[0091] 1. Ingredients:

[0092] Anti-Newcastle disease virus egg yolk antibody 99.5 kg

[0093] Traditional Chinese medicine polysaccharide 0.5 kg

[0094] The traditional Chinese medicine polysaccharide is extracted from the following Chinese medicinal material compositions in parts by weight: 10 pieces of Radix Radix Radix, 50 pieces of Radix Radix Radix, 50 pieces of Salvia Miltiorrhiza and 30 pieces of Poria cocos.

[0095] 2. Preparation:

[0096] (1) Prepare highly immune eggs against Newcastle disease virus.

[0097] (1.1) Specific pathogen-free laying hens are kept in isolation in clean farms;

[0098] (1.2) Laying hens are immunized 3 times, and each chicken is injected with Newcastle disease vaccine each time, and the injection volume is 0.5ml, 1.5ml and 2.0ml respectively, and the interval is on...

Embodiment 2

[0131] Example 2. Three-taste traditional Chinese medicine polysaccharide type chicken Newcastle disease concentrated freeze-dried egg yolk antibody compound preparation

[0132] 1. Ingredients:

[0133] Anti-Newcastle disease virus egg yolk antibody 65 kg;

[0134] Chinese medicine polysaccharide 6 kg;

[0135] Lactose 10 kg;

[0136] 2. Preparation:

[0137] The preparation method of yolk antibody and polysaccharide is the same as that in Example 1, except that the extraction source of polysaccharide is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Radix Radix Radix, 20 parts of Radix Radix, 10 parts of Poria;

[0138] The synthesis process and method of the compound preparation are the same as in Example 1, except that the synthetic raw materials become 65 kilograms of anti-Newcastle disease virus yolk antibody, 6 kilograms of polysaccharide and 10 kilograms of lactose.

[0139] 3. Quality standard:

[0140] With em...

Embodiment 3

[0141] Example 3. Concentrated and freeze-dried yolk antibody compound preparation of chicken Newcastle disease with two flavors of traditional Chinese medicine polysaccharide type

[0142] 1. Ingredients:

[0143] Anti-Newcastle disease virus egg yolk antibody 40 kg;

[0144] 20 kg of polysaccharides;

[0145] 6 kg skim milk powder;

[0146] 2. Preparation:

[0147] The preparation method of yolk antibody and polysaccharide is the same as in Example 1, except that the extraction source of polysaccharide is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Poria cocos, 30 parts of Danshen;

[0148] The synthetic process and the method of compound preparation are the same as embodiment 1, just change 40 kilograms of anti-Newcastle disease virus egg yolk antibodies, 20 kilograms of polysaccharides and 6 kilograms of skimmed milk powders at synthetic raw materials.

[0149] 3. Quality standard:

[0150] With embodiment 1.

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Abstract

The invention provides a concentrated and freeze-dried yolk antibody composite preparation for Newcastle disease, which comprises the following components in part by weight: 10.0 to 99.5 parts of Newcastle disease virus resistant yolk antibody and 0.5 to 20.0 parts of Chinese medicinal polysaccharide. The preparation is a freeze-dried preparation prepared by combining the components such as the Newcastle disease virus resistant yolk antibody and the polysaccharide under the guidance of immunity engineering of Chinese medical science, is clinically used for the Newcastle disease, has the effect of treating Newcastle disease virus infection, and excites the immunity and disease resistance of organisms; and simultaneously, the polysaccharide component in the preparation has powerful protection effect on the yolk antibody.

Description

technical field [0001] The invention relates to an antibody compound preparation, in particular to a chicken Newcastle disease concentrated freeze-dried egg yolk antibody compound preparation and a preparation method thereof. Background technique [0002] Chicken Newcastle disease is the enemy of the chicken industry. Anti-infective drugs currently used in the prevention and treatment of chicken Newcastle disease include antibiotics, chemical synthetic drugs, traditional Chinese medicine and its preparations, hyperimmune egg yolk antibodies and other anti-infective biological agents. [0003] (1) Antibiotics [0004] Such anti-infective drugs are mainly metabolites produced by microorganisms such as bacteria, fungi, and actinomycetes, as well as artificially imitated synthetic or semi-synthetic antibiotics. They have a strong inhibitory or killing effect on pathogenic microorganisms, a wide antibacterial spectrum, and good curative effect. They are mainly used as an auxili...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61P31/14A61P37/04C08B37/00C07K16/10A61K31/715
Inventor 李尚波苗玉和胥桂华张勇飞赵冰武洁梅
Owner LIAONING YIKANG BIOLOGICAL CORP LTD
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