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Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof

A technology for bursal disease and chicken infectivity, applied in the direction of antibodies, antiviral agents, allergic diseases, etc., can solve the problems of difficult implementation, difficult clinical wide acceptance, high price, etc., and achieve long-term action and good therapeutic effect , the effect of effective control effect

Active Publication Date: 2011-11-16
LIAONING YIKANG BIOLOGICAL CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] For example, interferon, cytokines, etc., are difficult to be widely accepted clinically due to their high price, and it is even more difficult to implement them in chicken infectious bursal disease

Method used

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  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1. Concentrated freeze-dried egg yolk antibody compound preparation of multi-flavored traditional Chinese medicine polysaccharide type chicken infectious bursal disease

[0097] 1. Ingredients:

[0098] Anti-Chicken Infectious Bursal Disease Virus Egg Yolk Antibody 99.5kg

[0099] Traditional Chinese medicine polysaccharide 0.5 kg

[0100] The traditional Chinese medicine polysaccharide is extracted from the following Chinese medicinal material composition in weight ratio: Angelica 10, Codonopsis 50, Astragalus 50, Poria cocos 30.

[0101] 2. Preparation:

[0102] (1), preparing highly immune eggs against chicken infectious bursal disease virus.

[0103] (1.1) Specific pathogen-free laying hens are kept in isolation in clean farms;

[0104] (1.2) Laying hens are immunized 3 times, each chicken is injected with chicken infectious bursal disease vaccine, and the injection volume is respectively 0.5ml, 1.5ml and 2.0ml, each interval of one week;

[0105] (1.3)...

Embodiment 2

[0138] Example 2. Concentrated freeze-dried egg yolk antibody compound preparation for chicken infectious bursal disease with three flavors of traditional Chinese medicine polysaccharide

[0139] 1. Ingredients:

[0140] Anti-infectious bursal disease virus egg yolk antibody 65 kg;

[0141] Chinese medicine polysaccharide 6 kg;

[0142] 10 kg of sucrose;

[0143] 2. Preparation:

[0144] The preparation method of yolk antibody and polysaccharide is the same as that in Example 1, except that the extraction source of polysaccharide is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Angelica sinensis, 20 parts of Codonopsis pilosula, 10 parts of Poria cocos;

[0145] The synthesis process and method of the compound preparation are the same as in Example 1, except that the synthetic raw materials become 65 kilograms of anti-infectious bursal disease virus yolk antibody, 6 kilograms of polysaccharide and 10 kilograms of sucrose. ...

Embodiment 3

[0148] Example 3. Concentrated freeze-dried egg yolk antibody compound preparation of chicken infectious bursal disease with two kinds of traditional Chinese medicine polysaccharide type

[0149] 1. Ingredients:

[0150] Anti-infectious bursal disease virus egg yolk antibody 40 kg;

[0151] 20 kg of polysaccharides;

[0152] 6 kg skim milk powder;

[0153] 2. Preparation:

[0154] The preparation method of yolk antibody and polysaccharide is the same as in Example 1, except that the extraction source of polysaccharide is changed to the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Poria cocos, 30 parts of Astragalus membranaceus;

[0155] The synthetic process and the method of compound preparation are the same as embodiment 1, just change 40 kilograms of anti-chicken infectious bursal disease virus egg yolk antibodies, 20 kilograms of polysaccharides and 6 kilograms of skimmed milk powders at synthetic raw materials.

[0156] 3. Qual...

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Abstract

The invention provides a concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease, which contains the following components in part by weight: 10.0 to 99.5 parts of infectious bursal disease virus resistant yolk antibody and 0.5 to 20.0 parts of Chinese medicinal polysaccharide, wherein the Chinese medicinal polysaccharide is extracted from one or a composition of more than two of the following Chinese medicines in part by weight: 10 to 50 parts of Chinese angelica, 50 to 100 parts of szechwon tangshen root, 50 to 80 parts of membranous milkvetch root and 30 to 50 parts of Indian buead. The preparation is a freeze-dried preparation prepared by combining the components such as the infectious bursal disease virus resistant yolk antibody and the polysaccharide under the guidance of immunity engineering of Chinese medical science, is clinically used for the infectious bursal disease, has the effect of treating infectious bursal disease virus infection, and excites the immunity and disease resistance of organisms; and simultaneously, the polysaccharide component in the preparation has powerful protection effect on the yolk antibody.

Description

technical field [0001] The invention relates to an antibody compound preparation, in particular to a chicken infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation and a preparation method thereof. Background technique [0002] Chicken infectious bursal disease is the enemy of the poultry industry. Anti-infective drugs currently used in the prevention and treatment of chicken infectious bursal disease include antibiotics, chemical synthetic drugs, traditional Chinese medicine and its preparations, hyperimmune egg yolk antibodies and other anti-infective biological agents. [0003] (1) Antibiotics [0004] Such anti-infective drugs are mainly metabolites produced by microorganisms such as bacteria, fungi, and actinomycetes, as well as artificially imitated synthetic or semi-synthetic antibiotics. They have a strong inhibitory or killing effect on pathogenic microorganisms, a wide antibacterial spectrum, and good curative effect, and are m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61P31/14A61P37/04C08B37/00C07K16/10A61K31/715
Inventor 李尚波苗玉和胥桂华张勇飞赵冰武洁梅
Owner LIAONING YIKANG BIOLOGICAL CORP LTD
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