Method for preparing 2,3,5-tri-O-tribenzyl-1-chloro-D-arabinofuranose

A technology of arabinofuranose and benzyl, which is applied in the field of preparation of 2,3,5-tri-O-tribenzyl-1-chloro-D-arabinofuranose, which can solve the problem of increased man-hours, decreased yield, and material consumption and increased energy consumption
CN101696227AInactive Publication Date: 2010-04-21邓俐丽
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
邓俐丽
Publication Date
2010-04-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to 2,3,5-tri-O-tribenzyl-1-chloro-D-arabinofuranose, which is used for producing important intermediates of anti-cancer drugs, such as nelarabine, fludarabine, ancitabine and the like. The invention relates to a method for preparing the 2,3,5-tri-O-tribenzyl-1-chloro-D-arabinofuranose. The method can acquire a solid-state target product which is convenient to store, transport and use.
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Description

field of invention

[0001] The invention relates to a preparation method of an anticancer drug intermediate 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose. technical background

[0002] 2,3,5-Tri-O-tribenzyl-1-chloro-D-arabinofuranose is used to prepare anticancer drugs such as nelarabine, fludarabine, cytarabine, and adenosine important intermediates. The 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose obtained by the existing technology is a kind of oil, which is not convenient for storage, transportation and use. Generally, it is first prepared as follows: The 2,3,5-tri-O-benzyl-1-O-p-nitrobenzoyl-D-arabinofuranose of (III) is temporarily chlorinated to obtain 2,3,5-tri -O-benzyl-1-chloro-D-arabinofuranose (Li Yeqing, Lu Ming, Lu Chunxu, Lu Hongfei. Synthesis of fludarabine. Jiangsu Chemical Industry, 2005, 33(3): 121-123).

[0003]

[0004] Literature: Li Liwei, Dai Xuyong, Cheng Zhigang. Synthesis of 2,3,5-tri-O-benzyl-1-O-p-nitrobenzoyl-D-arabinofuranose. China Journ...

Claims

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