Chinese medicine prescription granule flavoring agent, and preparation method and use method thereof

A technology of traditional Chinese medicine formula granules and flavoring agents, which is applied in the direction of medical formulas and medical preparations with non-active ingredients, etc. It can solve problems such as inability to achieve a good taste-masking effect, unsuitable traditional Chinese medicine formula granules, and limited flavoring effect , to achieve good flavoring effect, low price, and pure sweetness

Active Publication Date: 2011-08-17
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, film coating technology is often used for taste-masking of tablets, but for traditional Chinese medicine formula granules, due to the large specific surface area of ​​the granules, the amount of adjuvant required for coating is large, so it is not suitable for taste-masking of traditional Chinese medicine formula granules; The combination technology is to wrap the drug in the cavity of the main molecule such as cyclodextrin, which can reduce the contact between the drug and the taste buds, and achieve the purpose of flavoring. The ratio is more than 1:1, so it is not suitable for flavor correction of traditional Chinese medicine formula granules; there are few domestic researches on resin adsorption technology, and there are few ion exchange resin materials that can be used for medicine; waxy material encapsulation technology, emulsion encapsulation technology , The effervescent technology is complicated, and the operation requirements are high; the use of sweeteners or food flavors alone has limited taste correction effects, especially in the case of many components and large doses of traditional Chinese medicine compound, the simple use of some sweeteners or food flavors cannot Good taste masking effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0034] Dosage (1 bag)

[0035] Carrageenan and konjac gum (1:0.5 by weight) 0.8g

[0036] Sucralose 0.007g

[0037] Ethyl Maltol 0.011g

[0038] Hydroxylated phospholipids 0.021g

[0039] Maltodextrin 1.17g

[0040] Lemon flavor 0.04mg

[0041] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and lemon flavor evenly, add appropriate amount of water as binder, make wet granules, dry at 50-60°C, Made into traditional Chinese medicine formula granule flavoring agent.

[0042] Take 1 bag (0.5g) of Coptidis traditional Chinese medicine formula granules and 1 bag of corrective agent and pour it into a container, add 100ml of hot water, stir evenly, put it in a 4°C environment to cool, and take it after it is frozen. The results show that Coptidis Chinese medicine can be significantly improved. Bitter taste of formula granules.

Embodiment 2

[0044] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0045] Dosage (1 bag)

[0046] Carrageenan and konjac gum (1:1 by weight) 1.0g

[0047] Sucralose 0.015g

[0048] Ethyl Maltol 0.012g

[0049] Hydroxylated phospholipids 0.05g

[0050]Maltodextrin 1.10g

[0051] Peach flavor essence 0.08mg

[0052] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and peach flavor evenly, add an appropriate amount of water as a binder, make wet granules, and dry at 50-60°C , made into traditional Chinese medicine formula granule flavoring agent.

[0053] Take 1 bag (0.5g) of Coptidis traditional Chinese medicine formula granules and 1 bag of corrective agent and pour it into a container, add 100ml of hot water, stir evenly, put it in a 4°C environment to cool, and take it after it is frozen. The results show that Coptidis Chinese medicine can be significantly improved. Bitter taste of formula...

Embodiment 3

[0055] Traditional Chinese medicine formula granule flavoring agent and preparation method thereof:

[0056] Dosage (1 bag)

[0057] Carrageenan and konjac gum (1:2 by weight) 1.2g

[0058] Sucralose 0.012g

[0059] Ethyl Maltol 0.013g

[0060] Hydroxylated Phospholipids 0.08g

[0061] Maltodextrin 0.75g

[0062] Strawberry Flavor 0.08mg

[0063] Mix carrageenan, konjac gum, sucralose, ethyl maltol, hydroxylated phospholipids, maltodextrin and peach flavor evenly, add an appropriate amount of water as a binder, make wet granules, and dry at 50-60°C , made into traditional Chinese medicine formula granule flavoring agent.

[0064] Take 1 bag of tangerine peel, honeysuckle, and forsythia traditional Chinese medicine formula granules (3.5g in total) and 1 bag of flavoring agent, pour it into a container, add 100ml of hot water, stir well, cool it to room temperature, and take it after freezing. The results show that It can significantly improve the bitterness and astringen...

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PUM

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Abstract

The invention relates to a Chinese medicine prescription granule flavoring agent, and a preparation method and a use method thereof. The Chinese medicine prescription granular flavoring agent is used for improving the mouthfeel of single-flavor or compound Chinese medicine prescription granules. The flavoring agent comprises the following raw materials in percentage by weight: 30-60% of mixture of carrageenin and konjac gum, 0.3-1.0% of trichloroesucrose, 0.5-0.8% of ethyl maltol, 1-4% of hydroxylated phospholipids, 35-60% of maltodextrin and 0.001-0.004% of fruit-flavor essence. The preparation method comprises the following steps: evenly mixing the carrageenin, the konjac gum, the trichloroesucrose, the ethyl maltol, the hydroxylated phospholipids, the maltodextrin and the fruit-flavor essence; making into wet granules by adding a proper amount of water as the adhesive; and drying at the temperature of 50-60 DEG C to obtain the Chinese medicine prescription granule flavoring agent. The use method comprises the following steps: pouring the Chinese medicine prescription granules to be taken and the flavoring agent into a container, adding hot water, stirring, and waiting until themixture is frozen. The invention has the advantages of simple technique and convenient use, and has favorable flavor masking effect.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine formula granule flavoring agent and a preparation method and application method thereof. It is used to improve the taste of single or compound Chinese medicine formula granules. It belongs to the field of traditional Chinese medicine preparations. (2) Background technology [0002] Traditional Chinese medicine formula granules are single-flavor granules prepared by water extraction, concentration and drying under the guidance of traditional Chinese medicine theory. It is recognized and accepted by clinical patients and doctors for its stable quality, accurate dosage, convenient administration, safety and sanitation. However, due to the high drug concentration and poor taste of traditional Chinese medicine formula granules, they often have unpleasant tastes such as bitterness, astringency, and sourness, which make patients feel uncomfortable and even vomit when they use them, especially child...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/00
Inventor 过科家吴华欣陈盛君周嘉琳
Owner JIANGYIN TIANJIANG PHARMA
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