Application of pseudo-ginseng and extract thereof in preparing medicament for curing and/or preventing diabetic neuropathies
A technology of diabetes and Panax notoginseng, which is applied in the field of preparation of drugs for treating and/or preventing diabetic neuropathy, can solve the problems of complex ingredients, lack of action mechanism of ingredients, research and the like, and achieves the effect of high safety
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Embodiment 1
[0096] Take notoginseng and grind it into 1000g of coarse powder, add 7000ml of 65% ethanol to extract for 7 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, gradient elution with different concentrations of ethanol, the ethanol concentration is adjusted from 5% to 95% within 6 hours , flow rate 4.5BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and concentrate To a clear paste with a relative density of 1.13 (60° C.), the active ingredient of Panax notoginseng saponins is obtained, and water for injection is added to adjust to contain 100 m...
Embodiment 2
[0099] Take notoginseng and grind it into 1000g of coarse powder, add 10000ml of 50% ethanol to extract for 6 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.4g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 5.5 hours ), the flow rate is 5.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.15 (60°C), dry it to obtain the active ingredient of Panax notoginseng saponins, add water for injection to adjust t...
Embodiment 3
[0102] Take notoginseng and grind it into coarse powder 1000g, add 75% ethanol 7500ml to extract for 8 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.6g crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 6.5 hours ), the flow rate is 4.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.16 (60°C) to obtain the active ingredient of Panax notoginseng saponins, add 0.30% (weight ratio) of activated carbon for injectio...
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