PH-sensitive dentritic polymer drug carrier

A polymer and dendritic technology, which can be used in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problems of poor chemotherapy effect and failure, and achieve the effects of large drug loading, good stability, and reduced treatment costs

Inactive Publication Date: 2010-05-19
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
View PDF0 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chemotherapy is currently the most important method in the treatment of malignant tumors other than su

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • PH-sensitive dentritic polymer drug carrier
  • PH-sensitive dentritic polymer drug carrier
  • PH-sensitive dentritic polymer drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1. Preparation of pH-sensitive dendrimer drug carrier

[0018] PAMAM and acrylic acid were reacted in a mol ratio of 1:64. Solvent DCM, catalyst DCC, DMAP were reacted at room temperature for 48 hours to obtain product 1. Filtered, dialyzed and lyophilized. Folic acid and PEG, mol ratio 1:1 solvent DCM, catalyst DCC, DMAP, react at room temperature for 24 hours to obtain FA-PEG. FA-PEG and acrylic acid, molar ratio 1:1, solvent DCM, catalyst DCC, DMAP, react at room temperature for 48h. Product 2 was obtained. Filtered, dialyzed and then freeze-dried. Product 1, product 2, monomer DEA, catalyst CuBr, Bpy, carry out polymerization reaction. The solvent is a mixed solvent of methanol and water. In a closed state, pass N2, remove O2, and react at 50°C for 8 hours under the protection of N2 to obtain the final product PAMAM-MA-PDEA-MAPEG-FA. The final product of the reaction was finally treated with dialysis and freeze-dried to obtain the final product.

[...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a pH-sensitive dentritic polymer drug carrier. The structure of the drug carrier is one of the following: (1) A-B-C, (2), (3) A-B-C-D and (4), wherein A is dentritic polymer core comprising repeated groups, B is pH-sensitive polymer, C is hydrophilic polymer and D is targeting molecule. The pH-sensitive dentritic polymer has a nano-grade grain diameter, and can be used for coating antitumor drug. Besides, the pH-sensitive dentritic polymer has strong tumor targeting effect in vivo, thereby releasing drug quickly after reaching the tumor position.

Description

technical field [0001] The invention relates to the fields of pharmaceutical polymer materials and biomedicine, in particular to a pH-sensitive dendritic polymer and its application as a drug carrier. The polymer can be used as a nano-carrier for antitumor drugs, antiviral drugs, and gene therapy drugs . Background technique [0002] Dendrimers are a kind of artificially synthesized macromolecules. Its invention is only more than 20 years ago, but its research has penetrated into various industries, its application range is continuously expanding, and its potential application value is eye-catching. Dendritic polymers are composed of repeating units. Polyamidoamine (PAMAM) is the most common. Its characteristics include highly symmetrical structure, perfect single-molecule nanospheres, extremely high functional group density on the surface, controllable size and shape, and unique physical and chemical properties. It has minimal toxicity and is not immunogenic. These proper...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/32A61K47/34A61P35/00A61K47/10
Inventor 金义光任霞杜丽娜杨江勇李淼
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap