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Preparation method of anti-seeping gel for stanching

An anti-seepage water and gel technology, which is applied in the field of preparation of hemostatic and anti-seepage hydrogel, can solve the problems of lack of adhesion, affecting the treatment effect and the like

Inactive Publication Date: 2010-06-09
淄博高新区联创科技服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many hemostatic materials cannot form a firm and dense organic whole with the tissue surface, that is, lack of certain adhesion, so that the material system cannot form a strong force with the tissue system, which ultimately affects the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 10 g of terminal acryloyl functionalized PEG-PLA copolymer (molecular weight is 3500, PEG2000:LA=1:10 (mol / mol), configure it into a 25% aqueous solution, apply it to the hemostatic site, add eosin Y initiator, After being irradiated with 510-530nm ultraviolet light, the gel can be formed within 30-60s, which can achieve ideal hemostatic and anti-seepage effects.

Embodiment 2

[0019] Take 10 g of terminal acryloyl functionalized PEG-PLA copolymer (molecular weight is 5000, PEG2000: LA = 1:8 (mol / mol), configure it into a 25% aqueous solution, apply it to the hemostatic site, add eosin Y initiator, After being irradiated with 510-530nm ultraviolet light, the gel can be formed within 30-60s, which can achieve ideal hemostatic and anti-seepage effects.

Embodiment 3

[0021] Take 10 g of terminal acryloyl functionalized PEG-PLA copolymer (molecular weight is 9000, PEG8000:TMG=1:10 (mol / mol), configure it into a 25% aqueous solution, apply it to the hemostatic site, add eosin Y initiator, After being irradiated with 510-530nm ultraviolet light, the gel can be formed within 30-60s, which can achieve ideal hemostatic and anti-seepage effects.

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PUM

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Abstract

The invention discloses a preparation method of biodegradable anti-seeping gel for stanching, wherein, the anti-seeping gel for stanching has good biodegradability and biocompatibility and reliability and can reduce or avoid the occurrence of seepage when being used for stanching and preventing errhysis after operations. The method comprises the following steps: at first, mixing two or more selected from terminal functionalized collagen, polyethylene glycol, alginate, polylactic acid and poly trimethylene dimethyl carbonate together, or using two or more copolymers selected from the above materials to prepare ethanol solution with the concentration of 25%, daubing on the using position; and then adding initiator to form gel under 510 to 530 nanometers of UV irradiation.The above substances form the target product with solvent water. The product only needs to be daubed on the part needing to avoid conglutination, and free radical initiator initiates the terminal double bonds of the above materials to form crosslinking, thereby sealing the tissue parts seeping blood and plasma to achieve the purpose of stanching and preventing seepage.

Description

technical field [0001] The invention relates to a preparation method of a novel medical biodegradable hemostatic and anti-seepage hydrogel, especially collagen, polyethylene glycol, alginate, polylactic acid, and polytrimethylene dimethyl carbonate functionalized at the end The preparation method of the hemostatic and anti-seepage water glue formed by blending two or more of the above materials, or using two or more copolymers of the above materials and solvents. Background technique [0002] Biomedical materials are the product of the intersection of life science and material science, and are an important material basis for the development of modern clinical medicine. At present, they have become a research hotspot in all countries in the world. [0003] Bleeding and oozing in surgical and traumatic procedures has long been a problem in the medical community. For general common operations, such as cardiovascular surgery, liver and spleen surgery, abdominal surgery and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/62
Inventor 杨荣华张秀芹石汝军赵将玺韩娜
Owner 淄博高新区联创科技服务中心