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Medicinal composition for treating nevus flammeus and preparation method thereof

A technology for port-wine stain and a composition is applied in the field of medicine and its preparation, and can solve the problems of high dark toxicity, increase the number of patient treatments, and low safety, and achieve the effects of low toxicity and side effects, reducing the number of treatments, and high safety.

Inactive Publication Date: 2010-06-23
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented medicinal product described in this patents improves upon existing drugs used on top of it's own properties or uses them alone while also being able to cure certain types of blood vessel disease (BV). It works better at killing bacteria than other methods like silver nitrate but doesn’t harm their healthy tissues. Its technical benefits include its ability to effectively stop bleeding from capillaries that are damagingly affected due to wounds caused by alcohol abuse, making it easier to heal openings where there may have been previous injuries during medical procedures. Additionally, it provides long-term benefit through improved penetrating power when applied directly onto sensitive areas such as eyes.

Problems solved by technology

The technical problem addressed by this patents relates to reducing or eliminating port wine-staining caused by excessive exposure time during eye surgeries due to poor blood flow from arterial vessels supplying oxygenated tissue around affected areas. This results in increased risk of complications including blindness when treated through traditional procedures like suturing techniques.

Method used

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  • Medicinal composition for treating nevus flammeus and preparation method thereof
  • Medicinal composition for treating nevus flammeus and preparation method thereof
  • Medicinal composition for treating nevus flammeus and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0075] Preparation of reference substance stock solution: Accurately weigh 9.01mg of hypericin reference substance, add it into 20mL dimethyl sulfoxide, transfer it into a 250mL brown volumetric flask after completely dissolving, dilute to the mark with methanol, and precisely draw 1.00mL Put the above solution into a 10.0mL brown volumetric flask, dilute to the mark with methanol, and prepare a concentration of 3.60μg·mL -1 reference stock solution.

[0076] Linear relationship investigation: Precisely draw 0.20mL, 0.50mL, 1.00mL, 2.00mL, 5.00mL of the above-mentioned reference substance stock solutions, put them in a 5.00mL brown volumetric flask, and dilute to the mark with methanol to obtain reference substance solutions with different concentrations. According to the chromatographic conditions under "2.1", each concentration was injected 3 times, and each injection was 20 μL, and the integrated value of the peak area was measured. The standard curve was drawn with the in...

Embodiment 1

[0283] (1) Extraction of hypericin:

[0284] a), rough extraction

[0285] Mix the two with the ratio of M (Hypericia perforatum powder): V (ethanol with a concentration of 60%) as 1:20, ultrasonically treat for 15 minutes, control the temperature at 70°C, filter after reflux for 1.5 hours, and retain the filtrate; under the same conditions, After extracting the obtained filter residue twice with ethanol, the filtrates were combined, concentrated and dried to obtain hypericin extract.

[0286] b), macroporous resin refining

[0287] Mix the extract obtained in step a) with 15% ethanol, sonicate for 15 minutes to dissolve, filter, adjust to a concentration of 5 mg / mL, and separate and purify by S898 macroporous adsorption resin: use the macroporous adsorption resin and the liquid medicine Mix the two at a volume ratio of 1:1, control the adsorption flow rate to be 1.5 bed volume / hour, control the resin column diameter-to-height ratio to be 1:5, wash with water for 3 times the...

Embodiment 2

[0295] The extraction of hypericin is the same as in Example 1; the preparation of the injection of this embodiment:

[0296] 99mg hypericin; add 1000mg absolute ethanol, 2000mg glycerin, and 800mg water; add 5200mg Tween-80 to solubilize, stir and dissolve, adjust the pH value to 7 with triethylamine, and finally dilute with water for injection to 7500.0mL, sterilized by filtration, and then packed to obtain a brownish-red clear aqueous solution, which was stored in a refrigerator at 4°C to obtain an injection.

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Abstract

The invention relates to a medicinal composition for treating nevus flammeus and a preparation method thereof, wherein extraction and purification of hypericin are completed by the steps of (a) carrying out crude extraction, (b) refining by macroporous resin and (c) carrying out separation and purification; and the obtained hypericin is mixed with a medicinal carrier in a certain proportion to prepare the medicinal composition. The medicinal composition of the invention has the characteristics of effect on both mild and severe pathological changes, higher curative effect, lower dark toxicity and toxic and side effects, high safety degree, stronger synergistic effect with photodynamic affection, and capacity of addressing both the symptoms and root causes of nevus flammeus without carrying out the allergic test.

Description

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Claims

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Application Information

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Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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