33 results about "Nevus flammeus" patented technology

The invention discloses a port wine stains photodynamic diagnosis and treatment instrument, which includes a photodynamic cure device and an OCT scan device. One industrial control mainboard and one operation system are shared for the OCT scan device and the photodynamic cure device, the OCT scan device is equipped with a data interface for connecting an external computer. By cooperation of the OCT scan device and the photodynamic treatment device, the diagnosis and cure instrument detects microscopic section of processed pathological change skin tissue and confirms treatment effect on microscopic view, wherein imaging scan resolution can be in micron-level and exceeds traditional detection way far and away. The diagnosis and treatment instrument can real-time display section tissue structure images of detected position by using the OCT scan device, realize image processing functions to make the images more clear and provide scientific evidence for pathological change diagnosis and estimation of therapeutic effect. The diagnosis and cure instrument resolves problem in prior art that estimations of skin pathological change part by visual observation and experience and to therapy results are inaccurate.

The invention relates to the technical field of medicines and in particular relates to a novel chlorine photosensitizer-pyropheophorbide-a ether amino acid derivative, a preparation method thereof and an application to preparation of antitumor medicines. A chemical structure of the pyropheophorbide-a ether amino acid derivative is shown in a general formula (I) in the specification. The pyropheophorbide-a ether amino acid derivative has the advantages of high efficiency, low toxicity and the like, and can be used for preparing new medicines for photodynamic therapy of cancers, medicines for photodynamic therapy of benign vascular diseases, such as age-related macular degeneration and nevus flammeus and medicines for photodynamic therapy of condyloma acuminate.

The invention discloses a photoacoustic microscopy imaging-based quantitative detection device for a nevus flammeus blood vessel. The device comprises two parts, namely hardware and software, wherein the hardware comprises a light emitting system, an optical rapid scanning system, a photoacoustic detection system, an X, Y and Z-axis motor positioning system and a host computer system; the software comprises driving, deconvolution and filter back-projection algorithms of various hardware, and three scanning imaging modes; the imaging depth of the device is 2mm; the transverse resolution is 3.8mu m; the axial resolution is 40mu m; the imaging range is 0.5mm or 1mm; the problem that a pure optical method cannot reach the imaging depth, and ultrasound cannot reach the resolution are solved; two-dimensional and three-dimensional structure imaging is adopted, so that the parameters such as pipe diameter and depth of the blood vessel, and relative blood volume percentage distributed along the depth direction can be quantitatively counted; the defects and disadvantages in an existing clinical PWS detection technology are solved; and a non-destructive real-time multi-mode detection method is provided for PWS pathological study.

The invention relates to novel chlorin e6 derivatives, pharmaceutically acceptable salts thereof, as well as preparation methods and applications of the novel chlorin e6 derivatives and the pharmaceutically acceptable salts and belongs to the technical field of medicines. The chlorin e6 ether amino acid derivatives comprise compounds shown as the general structural formula I and optical isomers ofthe general structural formula I. The preparation method of the novel chlorin e6 derivatives comprises steps as follows: 3-vinyl in chlorin e6 is etherified, and 15-ethylcarboxyl and amino acid are subjected to peptides formation. The chlorin e6 ether amino acid derivatives and the pharmaceutically acceptable salts thereof can be taken as photodynamic antitumor drugs for application. Compared with an existing clinically applied similar photosensitizer talaporfin, the chlorin e6 ether amino acid derivatives have the advantages of being high in photodynamic antitumor activity, high in ratio ofdark toxicity to phototoxicity and the like and can be applied to preparation of new photodynamic antitumor drugs including photodynamic cancer treating drugs, photodynamic treatment drugs for benignvascular diseases such as senile macular degeneration and nevus flammeus as well as photodynamic treatment drugs for condyloma acuminate.

The invention relates to the technical field of medicines and particularly relates to a novel chlorin photosensitizer, i.e., a chlorin p6 amino acid derivative, a preparation method therefor and use of the chlorin p6 amino acid derivative in preparation of antitumor drugs. The chlorin p6 amino acid derivative disclosed by the invention has a chemical structure represented by a general formula (I) shown in the description. The chlorin p6 amino acid derivative disclosed by the invention has the advantages of high efficiency, low toxicity and the like and can be used for preparing novel photodynamic cancer therapy drugs, drugs for photodynamic therapy on benign vascular diseases such as senile macular degeneration and nevus flammeus and drugs for photodynamic therapy on verruca acuminata.

The invention provides an intelligent nevus flammeus photodynamic treatment instrument system. The system is characterized in that, a host is an independent treatment light source host having the wireless or wired network networking function. The host is connected with the wireless internet through an independent 4G module and forms an intelligent control system together with a PC machine and an intelligent power meter. The intelligent control system transmits data through the internet, manages the working process of the treatment instrument, collects data and summarizes the data in real time. The data exchanged between all units of the intelligent control system is realized through the networking and interworking of a 4G network. Meanwhile, the resource sharing among multiple systems and the global interconnection and interworking among the systems are realized through a wireless or wired network. According to the invention, according to special requirements during the treatment of nevus flammeus diseases by adopting a semiconductor narrow-spectrum light source, the intelligent nevus flammeus photodynamic treatment instrument and the overall treatment process thereof are intelligently controlled.

The present invention is the application of hypocrellin photosensitizer in pharmacy. Hypocrellin photosensitizer is used in preparing photodynamic medicine for treating nevus flammeus, senile macular degeneration and other blood capillary diseases.The said hypocrellin includes hypocrellin A, hypocrellin B and medicinal carrier. The present invention utilizes the photophysical and chemical features of hypocrellin photosensitizer, especially its maximum absorption spectrum value at 450-580 nm wavelength range, the light of which has effective penetrating depth of 1-2 mm to provide new clinicalindications for the hypocrellin.

The invention relates to a method for evaluating and optimizing blood vessel photodynamic therapeutic effects of different light dosages on the same experimental animal, in particular to therapeutic effects of a photodynamic method is used for treating vascular disease, such as nevus flammeus and choroidal vessels, and the method can be used for evaluating and optimizing illumination parameters of a pulse dye laser and other photo-thermal therapy for treating the vascular disease. According to the method, structured light irradiation with preset dosage is performed on the same experimental animal, and the method comprises the main steps of sample dissecting and dyeing, sample slicing and three-dimensional reconstructing, and experimental data analyzing and evaluating, thereby obtaining the therapeutic evaluations of different light dosages on the same experimental animal. Through the method, clinical experiment animals can be greatly reduced, the evaluations of therapeutic effects of blood vessels in different depths and diameters can be provided, and the determination of the optimal illumination dosage is accelerated.

The invention relates to a precision photodynamic therapy system which comprises an intravenous device use for injecting photosensitizer to the human body and a laser used for the illuminating nevus flammeus lesion portion of the human body. The photodynamic therapy system further comprises a digital micromirror device, a weak light detection system and a computer, wherein the weak light detection system is used for motivating and measuring the fluorescence-emission of the photosensitizer and organization spectrum through ultraviolet, and transmitting the detection information to the computer; the computer is used for calculating the concentration distribution of the photosensitizer in an organization according to the detection information, and generating a control signal for controlling the digital micromirror device; the digital micromirror device is used for adjusting the optical intensity distribution iradiated by the laser on the lesion portion under the control of the computer. By means of the precision photodynamic therapy system, the precision light dose delivery can be achieved, treatment effect is improved, and side effects are reduced.

The invention discloses a nevus flammeus photodynamic precise treatment system, which comprises a three-dimensional position adjusting device. The three-dimensional position adjusting device is provided with an imaging CCD, a 45-degree 510 nm mirror and an imaging lens group along a horizontal coaxial optical path. The imaging lens group is provided with a focal length adjusting device. An infrared temperature measuring probe is arranged on the right side of the three-dimensional position adjusting device. A 510 nm LED array is arranged on the front side of the 45-degree 510 nm mirror. An optical power detecting probe and an optical power detecting lens are arranged on the rear side of the 45-degree 510 nm mirror. The optical power detecting lens is disposed between the optical power detecting probe and the 45-degree 510 nm mirror. The system determines the shape and color distribution of the nevus flammeus on the surface of the skin, accurately outputs the spot size and the spot shape, and can adjust the light output power of different parts of the spot to achieve precise treatment, can detect the optical power density in real time, can monitor the surface temperature of the focusin real time, ensures the safety of treatment, has a data upload function capable of uploading system parameters to the cloud server in real time.

The invention relates to the technical field of medicines, and concretely relates to a novel dihydroporphine photosensitizer - purpurin-18 ether derivative, a preparation method thereof, and a use of the purpurin-18 ether derivative in the preparation of antitumor medicines. The chemical structure of the purpurin-18 ether derivative is represented by general formula (I) shown in the description. The purpurin-18 ether derivative has the advantages of high efficiency and low toxicity, and can be used for preparing new photodynamic therapy medicines of cancers, photodynamic therapy medicines of benign diseases, such as senile macula lutea denaturation and nevus flammeus, and photodynamic therapy medicines of condyloma acuminatum.

The invention discloses a traditional Chinese medicine composition for treating stains and verrucous nevi and a preparing method thereof, and belongs to the technical field of preparation of medicine.The traditional Chinese medicine composition is prepared from, by weight, 3-8 parts of radix angelicae, 15-25 parts of semen coicis, 2-5 parts of herba taraxaci, 2-6 parts of rhizoma atractylodis, 3-6 parts of powder of cornu bubali, 1-8 parts of semen euphorbiae lathyridis, 1-4 parts of tea tree oil, 3-12 parts of oleum fructus bruceae, 5-8 parts of ethyl alcohol, 4-9 parts of glutinous rice flour, 3-4 parts of sodium carbonate, 3-4 parts of calcium hydroxide, 2-5 parts of medical talc powder and 3-8 parts of pearl powder. Main traditional Chinese medicinal materials are cooperative with oneanother and jointly achieve the effects of reliving internal heat or fever, removing blood stasis and disintegrating masses, stopping bleeding by astringency, and relieving internal heat or fever forpromoting tissue regeneration; the composition quickly penetrates through the skin and goes deep into the cells of a part which needs to be subjected to symptom removal, stops the lesions, supplies nutrients to the cells, and kills the lesion cells, and the purposes of removing skin stains and warts like moles are achieved; meanwhile, the traditional Chinese medicine composition can effectively relieve edema or abdominal distension, swelling and pain, and prevent the skin from being infected and festered, and thus it is prevented that scars are not left on the skin after stains and verrucousnevi are cured.

The invention relates to a diphenyltetrahydroporphin compound, a preparation method and application thereof. The compound has the following structure (I) which is shown in the description, wherein R1and R2 are positioned at the ortho-position (o-), meta-position (m-) or para-position (p-) of a benzene ring; R1 is -H or -OMe; R2 is -OCH2COOH or -OCH2CH2CH2COOH. The invention relates to the fieldsof photosensitive drugs (also called as a photosensitizer or photodynamic drug) and photodynamic therapy, and particularly relates to a diphenyltetrahydroporphin photosensitizer, a preparation methodand application in the field of medicines. The diphenyltetrahydroporphin compound prepared by the method provided by the inventionvis stable in chemical property, has strong photodynamic activity, andcan be used as a drug for photodynamic diagnosis and treatment of diseases such as tumors, macula-retinae degeneration, actinic keratosis, nevus flammeus and condyloma acuminata and the like.

The invention relates to a diphenyldihydroporphin compound, a preparation method and application thereof. The compound has the following structure (I) which is shown in the description, wherein R1 andR2 are positioned at the ortho-position (o-), meta-position (m-) or para-position (p-) of a benzene ring; R1 is -H or -OMe; R2 is -OCH2COOH or -OCH2CH2CH2COOH. The invention relates to the fields ofphotosensitive drugs (also called as a photosensitizer or photodynamic drug) and photodynamic therapy, and particularly relates to a diphenyldihydroporphin photosensitizer, a preparation method and application in the field of medicines. The diphenyldihydroporphin compound prepared by the method provided by the invention is stable in chemical property, has strong photodynamic activity, and can be used as a drug for photodynamic diagnosis and treatment of diseases such as tumors, macula-retinae degeneration, actinic keratosis, nevus flammeus and condyloma acuminata and the like.

The invention discloses an externally used electuary for treating naevus, which is prepared from raw materials including sodium hydrogen carbonate powder 10-15 parts, pearl powder 3-5 parts, borneol 3-5 parts, calcium dioxide 80-100 parts, 95% ethanol 50-60 parts, and right amount of water.

The invention discloses a nevus flammeus color and area assessment method based on digital photo pixel analysis. The assessment method comprises the following steps: 1) making a nevus flammeus reference color card; 2) setting up a photograph environment, taking a face photo and implementing brightness normalization on the face photo; 3) taking color block photos of a nevus flammeus color card in the photograph environment which is set up, and computing a transfer matrix M that RGB values of the color block photos are converted into XYZ three-stimulation values via a polynomial regression method; and 4) computing an L*a*b* color coordinate value of each pixel point of a target area in the face photo in accordance with the transfer matrix M, and implementing color classification as well as color difference and area computation on nevus flammeus in accordance with the L*a*b* values. According to the method provided by the invention, skin color is subjected to accurate and objective quantification via the digital photo, a computed result is similar to a measuring result of a standard spectrocolorimeter and the nevus flammeus undergoes quantitative assessment via objective color values,so that errors, which are caused by subjective reasons when disease conditions are assessed by doctors via naked eyes, are avoided; therefore, a face pigment pathological change recording, analyzingand assessing technology, which is strong in practicability, is provided to the clinical field.

The invention relates to pyropheophorbide-a methyl ether compounds, and a preparation method and application thereof. The compounds have the structure (I) in the specification. The invention relates to the fields of photodynamic therapy and photosensitive drugs (also called photosensitizers or photodynamic drugs), particularly a chlorophyll derivative photosensitizer and a preparation method thereof, and application of the chlorophyll derivative photosensitizer in the field of medicine. The photodynamic drug provided by the invention has the advantages of stable chemical properties, high solubility in water, and very high photodynamic activity, and can be used as a drug for the photodynamic diagnosis and treatment of tumors, retinal macular degeneration, actinic keratosis, nevus flammeus, condylomata acuminata and other diseases.

The invention relates to a novel porphin diether salt compound (I) as well as a preparation method and application thereof. The compound (namely, porphin diether disodium salt, porphin diether dimethyl salt, porphin diether dilithio salt and porphin diether diammonium salt compound) has a structure shown in the description. The compound provided by the invention has the advantages of single component, stable property, controllable quality, simple and convenient preparation method and high water solubility, and can be easily prepared into an injection or a freeze-drying preparation. The compound has remarkable photodynamic activity, and can be applied to photodynamic therapy of tumors, retina macular degeneration, actinic keratosis, nevus flammeus, verruca acuminate and the like.

The invention relates to a tetraphenylmethylene chlorin compound, and a preparation method and application thereof. The tetraphenylmethylene chlorin compound has a following structure (I) as shown in the description, wherein R1 and R2 located in ortho-positions (o-), meta-positions (m-) or para-positions (p-) of a benzene ring. The invention relates to the field of photosensitive drugs (also named photosensitizers or photodynamic sensitizers) and photodynamic therapy, and in particular to methylene chlorin photosensitizer, and the preparation method and the application thereof in the field of medicine. The tetraphenylmethylene chlorin photosensitizer prepared by the invention has stable chemical property and very strong photodynamic activity and can be used for photodynamic therapy of diseases of tumors, retina macular degeneration, actinic keratoma, nevus flammeus, condyloma acuminata and the like.

The invention relates to a novel pyropheophorbide a derivative, a preparation method thereof and medical use. More specifically, the invention relates to a compound with a formula I as shown below, which is defined by the specification. The invention designs and prepares the pyropheophorbide a derivative which is single and stable in structure and simple and convenient in preparation method. The pyropheophorbide a derivative has very strong photodynamic activity, and can be used as a photodynamic drug for diagnosis and treatment of diseases such as tumor, macular degeneration, actinic keratosis, nevus flammeus and condyloma acuminata.

The invention relates to a novel chlorin e6 derivative and a preparation method and application thereof. The compound is of a following structure shown in the description. The invention relates to thefield of photosensitive medicine (also called as a photosensitizer or photodynamic medicine) and photodynamic therapy and especially relates to a chlorin photosensitizer, a preparation method thereofand application thereof to the field of medicine. The photosensitive medicine disclosed by the invention has advantages of stable chemical property, very strong photodynamic activity and applicationto photodynamic therapy of diseases of tumor, macular degeneration of retina, actinic keratosis, nevus flammeus, condyloma acuminata and the like.

Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal.

The present invention is an intelligent PWS photodynamic therapeutic apparatus system, characterized in that the host is an independent therapeutic light source host with a wireless or wired network networking function, the host is connected to the wireless Internet through an independent 4G module, and communicates with the The intelligent control system is composed of PC and intelligent power meter. The intelligent control system transmits data through the Internet, manages the working process of the therapeutic device and collects data in real time. Each unit of the intelligent control system communicates with each other through the 4G network. Data exchange, resource sharing of multiple systems through wireless or wired network, and global interconnection between systems. According to the special requirements of semiconductor narrow-spectrum light source for the treatment of PWS disease, the invention realizes intelligent control of the photodynamic treatment equipment and the whole process of treatment of PWS.

The invention relates to an optimization method of a projection direction used for controlling a projection device for nevus flammeus and the like in a PDT (Photodynamics Therapy). The method comprises the steps of optimizing a lighting direction in accordance with a normal vector weighting corresponding to 3D (three-dimension) surface patch of a focus under the precondition of obtaining a 3D focus area, and reducing a lighting angle formed between incident light and the D surface of the focus. In addition, the projection device can be controlled to light in an optimized direction by using the parameters of a visual system to obtain a position coordinate of the projection device, thereby improving the single lighting efficiency of the projection device and improving the curative effect of the single PDT.

A new method whitens the eye by continuously wearing away colored spots on the conjunctiva, such as nevi and pigmented lesions. The method includes the steps of selecting an area of the conjunctiva to be removed, including a colored portion; selecting and activating a motorized conjunctiva remover, which includes a body and an eye attachment with a tip; and, applying the tip of the eye attachment to the selected area of the conjunctiva to continuously wear away the conjunctiva until it is cleared of the colored portion. The eye attachments can be supplied with a variety of different tips.