Application of hypocrellin photosensitizer in pharmacy

A technology of hypocrellin and hypocrellin A, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problem that the depth of effective treatment cannot meet the needs of photodynamic therapy and anti-tumor drugs Difficulties, the anti-tumor photodynamic effect of hypocrellin is still in the basic research stage, etc.

Inactive Publication Date: 2003-11-05
GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the characteristics of the absorption spectrum of hypocrellin, the effective treatment depth cannot well meet the needs of photodynamic therapy for solid tumors. Compared with the new porphyrin and phthalocyanine photosensitizers, the advantages are not obvious, so it will be developed into a clinically available photodynamic therapy. Antineoplastic drugs have certain difficulties
Therefore, the research on the anti-tumor photodynamic effect of hypocrellin is still in the basic research stage.
However, the clinical efficacy of hypocretin as a phototherapy drug in the treatment of psoriasis and vitiligo has not yet been recognized.

Method used

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  • Application of hypocrellin photosensitizer in pharmacy
  • Application of hypocrellin photosensitizer in pharmacy
  • Application of hypocrellin photosensitizer in pharmacy

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Experimental program
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Embodiment 1-2

[0029] The extraction method is as follows:

[0030] 1. Extraction of hypocrellin A (HA)

[0031] The extraction method refers to the article of Zhao Kaihong's "Organic Chemistry" on pages 252-254 of volume 9 in 1989, and some improvements have been made on this method. The specific method is as follows: 20 g of crushed bamboo red fungus is placed in a Soxlet extractor, and 500 ml of chloroform is used as a solvent for continuous extraction for about 4 hours (until the extract is colorless), and the extract is repeatedly extracted with 4×100 ml of water. Separate the chloroform layer, remove the chloroform on a rotary evaporator, wash the solid with 8 × 25ml petroleum ether, dry the solid naturally in the air, then recrystallize twice with chloroform-petroleum ether, and the resulting crystal is the target product bamboo Rhodobactin A (HA), the purity is as high as 98%. Further purification can be achieved by thin layer chromatography (1% citric acid plate made of silica gel...

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Abstract

The present invention is the application of hypocrellin photosensitizer in pharmacy. Hypocrellin photosensitizer is used in preparing photodynamic medicine for treating nevus flammeus, senile macular degeneration and other blood capillary diseases.The said hypocrellin includes hypocrellin A, hypocrellin B and medicinal carrier. The present invention utilizes the photophysical and chemical features of hypocrellin photosensitizer, especially its maximum absorption spectrum value at 450-580 nm wavelength range, the light of which has effective penetrating depth of 1-2 mm to provide new clinicalindications for the hypocrellin.

Description

technical field [0001] The invention relates to the use of hypocrellin photosensitizers, in particular to the application of hypocrellin A (HA) or hypocrellin B (HB) in the field of pharmacy. Background technique [0002] Photodynamic therapy (PDT) refers to the administration of photosensitizers to the human body. When the drug has a maximum distribution in the lesion, light activates the photosensitizer, and generates active oxygen and other active intermediates with the participation of oxygen. Target cells to achieve the purpose of treating diseases. Photodynamic therapy began to be used in the clinical diagnosis and treatment of malignant tumors in the late 1970s, and in the 1990s to treat benign diseases such as port wine stains, macular degeneration, atherosclerosis, and psoriasis. The treatment of choice for moles and the only effective treatment for macular degeneration. [0003] Most photosensitizers currently approved for clinical use and currently in clinical t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/357A61P9/00A61P17/00
Inventor 顾瑛赵井泉刘凡光马江华赵跃伟谢杰
Owner GENERAL HOSPITAL OF PLA
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