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Blood vessel photodynamic therapeutic dose evaluation method

A technology of photodynamic therapy and evaluation methods, applied in measuring devices, material analysis through optical means, instruments, etc., can solve problems such as lack of

Inactive Publication Date: 2015-06-03
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology

The use of light dose has an important impact on the effect of photodynamic therapy. However, there is currently a lack of animal models for light dose evaluation, and the method of batch test animals is generally used, which cannot effectively resolve the differences in test data between different animals.

Method used

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  • Blood vessel photodynamic therapeutic dose evaluation method
  • Blood vessel photodynamic therapeutic dose evaluation method
  • Blood vessel photodynamic therapeutic dose evaluation method

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Embodiment Construction

[0010] The present invention will be described in further detail below in conjunction with the accompanying drawings and examples. Here, the exemplary embodiments of the present invention and their descriptions are used to explain the present invention, but not to limit the present invention.

[0011] according to figure 1 As shown, the test animal skin samples mainly include (1) blood vessels and their surrounding (2) skin tissue. Since the diameter and depth of skin blood vessels are different at different positions, the animal skin can be fixed by a fixing device before the test to facilitate light exposure. treat.

[0012] According to the needs of the test, it can be divided into 5 or more levels according to the light dose, and it is recommended to reserve non-illuminated areas between each dose level, or set markers in the interval areas, so as to facilitate the three-dimensional reconstruction and identification of samples after sectioning. figure 2 It is a bar-shap...

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Abstract

The invention relates to a method for evaluating and optimizing blood vessel photodynamic therapeutic effects of different light dosages on the same experimental animal, in particular to therapeutic effects of a photodynamic method is used for treating vascular disease, such as nevus flammeus and choroidal vessels, and the method can be used for evaluating and optimizing illumination parameters of a pulse dye laser and other photo-thermal therapy for treating the vascular disease. According to the method, structured light irradiation with preset dosage is performed on the same experimental animal, and the method comprises the main steps of sample dissecting and dyeing, sample slicing and three-dimensional reconstructing, and experimental data analyzing and evaluating, thereby obtaining the therapeutic evaluations of different light dosages on the same experimental animal. Through the method, clinical experiment animals can be greatly reduced, the evaluations of therapeutic effects of blood vessels in different depths and diameters can be provided, and the determination of the optimal illumination dosage is accelerated.

Description

technical field [0001] The invention relates to a method for evaluating and optimizing the effect of vascular photodynamic therapy by obtaining different light doses on the same experimental animal, especially the use of photodynamic methods to treat vascular diseases, such as port wine stains, choroidal vessels and other diseases, can also be used Evaluation and optimization of illumination parameters for photothermal therapy such as pulsed dye laser in the treatment of vascular diseases. Background technique [0002] Photodynamic therapy is a new technology that uses photochemical reactions for treatment. It has the advantages of minimally invasive, low toxicity, good selection applicability, repeatable treatment, and small side effects. The use of light dose has an important impact on the effect of photodynamic therapy. However, there is currently a lack of animal models for light dose evaluation, and the method of batch test animals is generally used for experiments, whi...

Claims

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Application Information

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IPC IPC(8): G01N21/84
Inventor 胡晓明张凤娟李勤
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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