Lung-targeting ceftiofur microsphere and preparation method thereof

A ceftiofur, lung targeting technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. problem, achieve good biocompatibility, solve the effect of insignificant curative effect, and delay the release
CN101756909AActive Publication Date: 2010-06-30QINGDAO VLAND BIOTECH INC +2
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
QINGDAO VLAND BIOTECH INC
Publication Date
2010-06-30

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Abstract

The invention provides a lung-targeting ceftiofur microsphere and a preparation method thereof, aiming at solving the problems that less medicine can reach the target part in the prior art, so that a great deal of medicine is wasted, the treatment effect is not remarkable, the toxic and side effect of the medicine is increased, and the probability of generating drug resistance is high. The technical scheme comprises: the microsphere takes ceftiofur as raw material and PLA as carrier material, and the weight ratio between the ceftiofur and the PLA is 1:0.5-10. The invention also provides the method for preparing the microsphere by emulsification. The microsphere prepared by the method has round appearance and shape, even grain fineness distribution, the average grain diameter of about 20mu m and higher medicine-loading rate. The microsphere can be used for treating lung infection of livestock and poultry with high effect, and leads the ceftiofur to be made into the lung-targeting microsphere so as to improve the concentration of the medicine at the lung tissues of animals and lead the medicine effect to be more remarkable, thus achieving the aims of slow release, long-term effect and target.
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Description

technical field

[0001] The invention belongs to the technical field of veterinary antibiotic preparations, and in particular relates to a lung-targeting ceftiofur microsphere and a preparation method. Background technique

[0002] Bacterial infectious diseases have always been one of the main diseases that endanger the aquaculture industry, causing serious economic losses to the aquaculture industry. At present, antibacterial drugs are mainly used clinically for the treatment of bacterial infectious diseases, and good results have also been achieved. However, in recent years, the serious problem of antibacterial drugs is the emergence of drug resistance, which leads to the reduction of the therapeutic effect of drugs. For example, in the treatment of lung diseases, it is necessary to increase the concentration of drugs in the lungs to achieve the therapeutic effect. Therefore, it is easy to cause the increase of drug residue in other tissues and produce some harmful side ef...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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