Polyethylene glycol electrolyte granular preparation and production method
A technology of polyethylene glycol and granule preparations, which is applied in the direction of medical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of poor therapeutic effect and poor quality of polyethylene glycol electrolyte compound preparations. control, taking cumbersome problems, etc., to achieve good results, reduce the incidence of disadvantages and side effects, and have a good taste
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preparation example 1
[0069] Preparation of Polyethylene Glycol Electrolyte Granules:
[0070] Weigh 13125g of polyethylene glycol 4000 and pulverize it, pass through a 60-mesh sieve to obtain fine particles of polyethylene glycol 4000 with a particle size (D90) of 250 μm. Weigh 178.5g of sodium bicarbonate, 350.7g of sodium chloride, 46.6g of potassium chloride, and 10g of acesulfame potassium, mix them, pulverize them, and pass through an 80-mesh sieve to obtain electrolyte fine particles with a particle size (D90) of 180 μm. After mixing the polyethylene glycol 4000 fine particles obtained above and the electrolyte fine particles uniformly according to the method of equal volume addition, use about 1371 g of 95 volume % ethanol aqueous solution to make a soft material, and then use a 40 mesh sieve to granulate, in a fluidized bed at 10 ° C ~ Boiling and drying at 60° C. for 20 minutes, sizing with a 40-mesh sieve to prepare polyethylene glycol electrolyte particles with a particle size (D90) of ...
preparation example 2~ preparation example 6
[0072] According to Table 1, change the composition and dosage of the preparation of polyethylene glycol electrolyte granule preparations, and the type of sieve used, and follow the same operation steps as in Preparation Example 1 to manufacture the polyethylene glycol electrolyte particles of Preparation Examples 2 to 6. Alcohol electrolyte granular preparation.
[0073]
[0074] Hereinafter, the technical effect of the polyethylene glycol electrolyte particle preparation and the manufacturing method thereof of the present invention will be further described through test examples.
[0075] In the present invention, the evaluation method of fluidity (angle of repose) is as follows.
[0076]
[0077] Take the sample particles and flow them into a circular watch glass from a small fixed funnel until the highest cone is obtained. Measure the height H and radius R of the cone, and calculate the angle of repose α according to the following formula. The larger the angle of rep...
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