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Meglumine adenosine cyclophosphate composite medicament

A technology of meglumine cyclic adenosine monophosphate and drugs, which is applied in the field of meglumine cyclic adenosine monophosphate combined medicine and its preparation, to achieve the effect of solid molding and fullness

Active Publication Date: 2010-07-21
安徽延寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adverse reactions of cyclic adenosine monophosphate meglumine and cyclic adenosine monophosphate in the prior art include: allergy, fever, rash, headache, back pain, abdominal pain, myalgia, nausea, weakness of limbs, numbness of hands and feet during intravenous infusion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The meglumine cyclophosphate combination medicine provided by the present invention is made of the following medicinal components by weight:

[0025] Meglumine Cyclophosphate 20

[0026] Lysine Aspirin 100

[0027] Reduced glutathione and vitamin C weight ratio 1:10-15 mixture 200

[0028] Meglumine cyclophosphate may be replaced by adenosine cyclophosphate, and the parts by weight are calculated as meglumine cyclophosphate.

[0029] The present invention also provides a method for preparing the above-mentioned combined medicine, the steps are as follows:

[0030] (1). Take the water for injection that the weight is 50-150 times the weight of the meglumine cyclophosphate, under stirring at 80-100 rev / min, separate the meglumine cyclophosphate, reduced glutathione Glycide, vitamin C, and lysine aspirin are completely dissolved to obtain a combined drug solution;

[0031] (2). The solution obtained in step (1) is ultrafiltered with a membrane with a molecular weight ...

Embodiment 2

[0038] The meglumine cyclophosphate combination medicine provided by the present invention is made of the following medicinal components by weight:

[0039] Meglumine Cyclophosphate 60

[0040] Lysine Aspirin 200

[0041] Reduced glutathione and vitamin C weight ratio 1:10-15 mixture 300

[0042] Meglumine cyclophosphate can be replaced by adenosine cyclophosphate, and the parts by weight are calculated as meglumine cyclophosphate.

[0043] The present invention also provides a method for preparing the above-mentioned combined medicine, the steps are as follows:

[0044] (1). Take the water for injection that the weight is 50-150 times the weight of the meglumine cyclophosphate, under stirring at 80-100 rev / min, separate the meglumine cyclophosphate, reduced glutathione Glycide, vitamin C, and lysine aspirin are completely dissolved to obtain a combined drug solution;

[0045] (2). The solution obtained in step (1) is ultrafiltered with a membrane with a molecular weight ...

Embodiment 3

[0052] The meglumine cyclophosphate combination medicine provided by the present invention is made of the following medicinal components by weight:

[0053] Meglumine Cyclophosphate 40

[0054] Lysine Aspirin 135

[0055] A mixture of reduced glutathione and vitamin C in a weight ratio of 1:10-15 276

[0056]The cyclic adenosine monophosphate meglumine may be replaced by cyclic adenosine monophosphate, and the parts by weight are calculated by the cyclic adenosine monophosphate meglumine.

[0057] The present invention also provides a method for preparing the above-mentioned combination medicine, the steps are as follows:

[0058] (1). Take water for injection whose weight is 50-150 times of the weight of the described meglumine cyclophosphate, and mix the described meglumine cyclophosphate and reduced glutathione respectively under stirring at 80-100 rpm Glycine, vitamin C, and lysine aspirin are completely dissolved to obtain a combined drug solution;

[0059] (2). The ...

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PUM

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Abstract

The invention relates to a meglumine adenosine cyclophosphate composite medicament or an adenosine cyclophosphate composite medicament which is prepared from pharmacodynamic components by weight part: 20 to 60 parts of meglumine adenosine cyclophosphate or adenosine cyclophosphate, 100 to 200 parts of lysine aspirin and 200 to 300 parts of mixture of reduced glutathione and vitamin C with the weight ratio of 1: (10 to 15). The invention also relates to a preparation method. The meglumine adenosine cyclophosphate composite medicament or the adenosine cyclophosphate composite medicament eliminates fever, tetter, pain and other adverse effects of meglumine adenosine cyclophosphate or adenosine cyclophosphate prepared by the prior art.

Description

technical field [0001] The present invention relates to a combination medicine of meglumine cyclophosphate and a preparation method thereof. Background technique [0002] Cyclic adenosine monophosphate (cAMP) is an important substance involved in regulating biological functions such as substance metabolism in cells. It has the functions of nourishing myocardium, positive inotropy, vasodilation, and anti-arrhythmia. As the second messenger of life information transmission, cAMP can make ATP-Ca on the cell membrane 2+ Ca in the complex 2+ released to change the function of cell membranes; also Ca in the sarcoplasmic reticulum 2+ Enter muscle fibers, thereby enhancing myocardial contractility and enhancing cardiac output. and dilate coronary arteries. Meglumine cyclophosphate is an organic salt of cycloadenosine. Adverse reactions of the prior art meglumine cyclophosphate and adenosine cyclophosphate include: allergy, fever, rash, headache, back pain, abdominal pain, myal...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/616A61K47/22A61K47/20A61K47/18A61K47/14A61K9/19A61P9/10
Inventor 邓学峰蔡海德
Owner 安徽延寿堂药业有限公司
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