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Method for enriching and purifying schizandrol A in schisandra

A technology of schisandra alcohol A and schisandra chinensis, applied in ether separation/purification, ion exchange, organic chemistry, etc., can solve the problems of low extraction rate and low extraction purity, and achieve high extraction purity, good thermal stability, fast adsorption and analysis fast effect

Active Publication Date: 2010-07-28
HEILONGJIANG DINGHENGSHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying Schizandrin A in Schisandra chinensis by using macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method utilizing macroporous adsorption resin to enrich and purify Schizandrin A in Schisandra chinensis, its steps are as follows:

[0027] (1) After crushing the dried schisandra, pass through a 60-mesh sieve, soak and extract with ethyl acetate 10 times the volume of the schisandra powder for 48 hours;

[0028] (2) suction-filtering the Schisandra chinensis extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0029] (3) Heat and dissolve the obtained primary extract with water, add acetic acid ethanol whose volume is 20 times the volume of the extract aqueous solution to extract, then adjust its pH value to 9.0 with alkali, leave it to stand, suction filter, and recover the solvent under reduced pressure to obtain Schisandra chinensis Methanol crude extract;

[0030] (4) Adsorb the obtained Schizandra alcohol methyl extract with a macroporous adsorption resin chromatography...

Embodiment example 2

[0035] Implementation case 2: a method for enriching and purifying schisandrin A in schisandra chinensis by using macroporous adsorption resin, the steps are as follows:

[0036] (1) crush the dried schisandra and pass through a 10-mesh sieve, soak and extract with acetone 20 times the volume of the schisandra powder for 12 hours, and then reflux and extract for 4 hours;

[0037] (2) suction-filtering the Schisandra chinensis extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0038] (3) heating and dissolving the obtained primary extract with water, adding acetic acid ethanol whose volume is 10 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 7.0 with ammonia water, standing, suction filtration, and concentrating under reduced pressure to obtain schisandra alcohol A crude extract;

[0039] (4) Adsorb the obtained Schizandrin A crude extract with a macroporous...

Embodiment example 3

[0044] Implementation case 3: a method for enriching and purifying schisandrin A in schisandra chinensis by using macroporous adsorption resin, the steps are as follows:

[0045] (1) After the dried schisandra is pulverized, pass through an 80-mesh sieve, and extract with 75% ethanol with 15 times the volume of the schisandra powder for 6 hours;

[0046] (2) suction-filtering the Schisandra chinensis extract treated in step (1) to obtain the extract and reclaim the initial extract of the solvent under reduced pressure;

[0047] (3) Heating and dissolving the obtained initial extract with water, adding acetic acid ethanol whose volume is 10 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 11.0 with aqueous sodium hydroxide solution, standing, suction filtration, and concentrating under reduced pressure Obtain the crude extract of schisandra alcohol A;

[0048] (4) the obtained Schisandrin A crude extract is adsorbed on a macroporo...

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Abstract

The invention belongs to the field of natural organic chemistry, relating to a method for enriching and purifying schizandrol A in schisandra by utilizing macroporous adsorbent resin. The invention is characterized in that the macroporous adsorption technology, which is used for separating and purfying the schizandrol A, has good adsorption selectivity on the schizandrol A, rapid adsorption, rapid resolution and large adsorption capacity; and the extraction is convenient and fast, the source of raw materials is abundant, the production cost is low, the separating effect is obvious, the extraction purity is high, and the semi-finished product of the schizandrol A of which the content is more than 35% and the final product of the schizandrol A of which the content is more than 98% can be obtained, so that the defects that relatively low extraction rate and low extraction purity of routine extraction are overcomed. The macroporous absorbent resin selected by the invention has stable physicochemical property, larger surface area, fast exchange speed, high mechanical strength, strong anti-pollution ability and good thermostability, thereby being capable of selectively adsorbing the schizandrol A from solution by physical adsorption with the characteristics of fast adsorption, fast resolution and larger adsorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying schisandrin A, in particular to a method for enriching and purifying schisandrin A in schisandra chinensis by using a macroporous adsorption resin. Background technique: [0002] Schisandra chinensis, commonly known as mountain pepper, weight dumpling, medicine schisandra, noodle vine, Wumeizi, etc., Tang et al. "Xinxiu Materia Medica" contains "five flavors are sweet and sour in the flesh, hard in the core, and have a salty taste", so it has the name of schisandra. Ancient medical books call it Chuzhu, Xuanji, and Huiji, which were first listed in the top grade of Shennong’s Herbal Classic. The efficacy of traditional Chinese medicine lies in the power of nourishing and strengthening, and its medicinal value is extremely high. Schisandra is a perennial deciduous vine, and the plants are available for viewing. It is the dry mature fruit of Magnoliace...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/23C07C41/34C07C41/36B01D15/08
Inventor 姚德坤姚德利闫峰姚航
Owner HEILONGJIANG DINGHENGSHENG PHARM CO LTD
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