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A kind of preparation method of chitosan/polyvinyl alcohol/polylactic acid blend dense film

A technology of polyvinyl alcohol and chitosan, which is used in medical science, absorbent pads, prostheses, etc., can solve the problems of staying and the performance of blended films that are rarely reported, and achieve good mechanical properties and good water vapor transmission. Transparency, beneficial to wound drying

Inactive Publication Date: 2012-02-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on the blended modified film with chitosan as the main body is deepening, but the research is mainly based on the blending of two substances, namely chitosan / polyvinyl alcohol blend or chitosan Sugar / polylactic acid blending, for example, the patent application number 200610002664.7 is about a preparation method of a chitosan / polyvinyl alcohol blend film, and the research on the properties of the blend film of three or more is rarely reported

Method used

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  • A kind of preparation method of chitosan/polyvinyl alcohol/polylactic acid blend dense film
  • A kind of preparation method of chitosan/polyvinyl alcohol/polylactic acid blend dense film

Examples

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Embodiment 1

[0024] Dissolve 3g of chitosan in 97g by weight of 2% acetic acid solution at 40°C to form a homogeneous solution. Dissolve 5 g of polylactic acid in 95 g (content ≥ 99 wt %) of dimethyl sulfoxide solution at 25° C. to form a uniform solution. Dissolve 7g of polyvinyl alcohol in 93g of deionized water at 100°C to form a uniform solution. Weigh 11.2g of chitosan solution, 0.6g of polyvinyl alcohol solution and 0.84g of polylactic acid solution, mix together at 25°C, stir for 30min, and defoam. Cast the defoamed mixed solution on polyester film and dry it at room temperature for 4 hours, then vacuum dry and heat-set at 25°C to obtain chitosan: polyvinyl alcohol: polylactic acid with a weight percentage of 8:1:1 Dense films of chitosan / polyvinyl alcohol / polylactic acid blends.

Embodiment 2

[0026] Weigh 12.6g of chitosan solution, 2.7g of polyvinyl alcohol solution and 1.26g of polylactic acid solution respectively, mix together at 25°C, stir for 30min, and defoam. Cast the defoamed mixed solution on polyester film and dry it at room temperature for 4 hours, then vacuum dry and heat-set at 25°C to obtain chitosan: polyvinyl alcohol; the weight percentage of polylactic acid is 6:3:1 Dense films of chitosan / polyvinyl alcohol / polylactic acid blends.

Embodiment 3

[0028] Weigh 11.2g of chitosan solution, 6g of polyvinyl alcohol solution and 1.68g of polylactic acid solution, mix together at 25°C, stir for 30min, and defoam. Cast the defoamed mixed solution on polyester film and dry it at room temperature for 4 hours, then vacuum dry and heat-set at 25°C to obtain chitosan: polyvinyl alcohol: polylactic acid with a weight percentage of 4:5:1 Dense films of chitosan / polyvinyl alcohol / polylactic acid blends.

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Abstract

The invention relates to a preparation method of chitosan / polyvinyl alcohol / polylactic acid blended dense film, comprising: (1) using acetic acid solution as a solvent to dissolve chitosan at 30-40° C. to obtain a weight percentage of 3% chitosan solution; (2) use dimethyl sulfoxide solution as a solvent to dissolve polylactic acid at room temperature to obtain a 5% polylactic acid solution by weight; (3) use deionized Water is used as a solvent to dissolve polyvinyl alcohol, and stirred until it is completely dissolved to obtain a 7% polyvinyl alcohol solution by weight; (4) mix the above three solutions in a certain proportion, and stir at a constant temperature of 20 to 30°C for 15 ~30min, and stand still for defoaming; (5) Make a blended dense film by casting method. The film-making process of the present invention does not involve toxic substances, and the film-making equipment and process are simple, biodegradable, convenient for clinical use, and can be used for artificial skin and dressings in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of preparation of polymer blended dense films, in particular to a preparation method of chitosan / polyvinyl alcohol / polylactic acid blended dense films. Background technique [0002] Artificial skin used to protect wounds from infection and dehydration has been widely used in the past few decades. Many polymer membranes and drug-loaded polymer membranes are used to manufacture biomaterials such as artificial skin. Chitosan is the only alkaline polysaccharide that exists in large quantities in nature. It has a wide range of sources, and it has good film-forming properties, is easy to modify, and can introduce various functional groups, making chitosan and its derivatives useful in the field of medicine. Very broad application prospects. When chitosan is used as a biological material, it has good biocompatibility, is non-toxic and has affinity to human cells, does not react with body fluids, and has no antigen-antibody...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L67/04C08L29/04C08J5/18A61L27/26A61L27/20A61L27/18A61L27/16A61L27/60A61L15/28A61L15/26A61L15/24
Inventor 张瑞云姜福青章斌
Owner DONGHUA UNIV
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