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Use of effective parts of galangal in preparation of medicine for treating vitiligo

An effective part, the technology of galangal, which is applied in the field of medicine and can solve the problems of galangal with many pharmacological effects

Inactive Publication Date: 2011-11-30
新疆维吾尔自治区维吾尔医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Galangal has many pharmacological effects, but there is no pharmacological use of it in the treatment of vitiligo

Method used

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  • Use of effective parts of galangal in preparation of medicine for treating vitiligo
  • Use of effective parts of galangal in preparation of medicine for treating vitiligo
  • Use of effective parts of galangal in preparation of medicine for treating vitiligo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] a. Using the rhizome of plant galanga as raw material, extract 3 times with 50% ethanol, the ratio of solid to liquid is 10 times, 8 times, 8 times, the extraction temperature is 60°C, and the time for each time is 2, 2, 1 hour, Obtain the total crude extract;

[0018] b. Dissolve the total crude extract with 30% ethanol by volume, absorb it with a polyamide column, and elute with 40% ethanol by volume, collect the eluate, concentrate the eluate under reduced pressure, and dry to obtain gaoliang The effective part of gingerin contains more than 50% of total flavonoids calculated by weight of dry product, and the content of galangin obtained by further preparing by preparative liquid chromatography is 20-99.8%.

Embodiment 2

[0020] a, using the plant galanga rhizome as raw material, extracting 3 times with 60% ethanol, the ratio of solid to liquid is 10 times, 8 times, 8 times, the extraction temperature is 65°C, and the time for each time is 2, 2, 1 hour, Obtain the total crude extract;

[0021] b. Extract the total crude extract with a petroleum ether solvent, dry the obtained extract to obtain a fat-soluble product, dissolve it in 40% ethanol by volume, absorb it with a macroporous resin, elute with 50% ethanol by volume, and collect The eluate is concentrated under reduced pressure and dried to obtain the effective part of galangin, which contains more than 50% of the total flavonoids based on the weight of the dry product, and is further prepared by preparative liquid chromatography to obtain a galangin content of 20% -99.8%;

Embodiment 3

[0023] a. Using the rhizome of plant galanga as raw material, extract 3 times with 70% ethanol, the ratio of solid to liquid is 10 times, 8 times, 8 times, the extraction temperature is 70°C, and the time for each time is 2, 2, 1 hour, Obtain the total crude extract;

[0024] b. Dissolving the total crude extract with 50% ethanol by volume, adsorbing with macroporous resin, eluting with 55% ethanol by volume, collecting the eluate, concentrating the eluate under reduced pressure, and drying to obtain galangal The active part of the galangin contains more than 50% of the total flavonoids calculated by the weight of the dry product, and the content of the galangin is 20-99.8% after further preparation by a preparative liquid chromatography.

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PUM

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Abstract

The present invention relates to the use of effective parts of galangal in the preparation of medicine for treating vitiligo. The total flavonoids of the effective parts are extracted from the rhizome of plant galanga, and then the total flavonoids of the extract are made into capsules, tablets, granules, Or drop pill dosage form use. Experiments show that the effective part containing galangin can promote the proliferation of melanocytes, up-regulate the activity of tyrosinase, and increase the content of melanin; inhibit the immune system of mice; The number of granulosa cells increased significantly, and the expression of tyrosinase was enhanced. It provides a new way to prepare the medicine for treating vitiligo from the rhizome of plant galanga.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of extracting effective parts containing galangin from the traditional Chinese medicine galangal as a medicine for treating vitiligo. Background technique [0002] Vitiligo is one of the three major worldwide intractable skin diseases, which occurs all over the world, and the incidence rate is about 1-2%. Moreover, the reports of recurring cases all over the world continue to rise. Vitiligo is a common multiple acquired, primary depigmentation of the skin, non-secondary depigmentation lesions left after other skin diseases, manifested as localized or generalized depigmentation lesions. The harmfulness of vitiligo not only affects the appearance of patients, but also imposes serious psychological pressure and mental pain on patients. Therefore, the prevention and treatment of this disease is of great significance. [0003] The pathogenesis of vitiligo is complex, and the etiolog...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/48A61K9/20A61K9/16A61P17/00A61K125/00
Inventor 闫明霍仕霞高莉康雨彤唐晓琴
Owner 新疆维吾尔自治区维吾尔医药研究所
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