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Method for preparing puerariae decoction particles
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A Gegen decoction and granule technology, applied in the field of medicine, can solve problems such as increasing the cost of Gegen decoction, potential safety hazards, and difficulty in granulating, so as to avoid toxic and side effects, ensure quality, and reduce the burden on patients
Active Publication Date: 2013-03-13
REYOUNG PHARMA
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Problems solved by technology
Most of these substances have a certain viscosity, which brings certain difficulties to granulation.
Because of its high viscosity, it is difficult to granulate with water. At present, granules can be prepared by two-step granulation with high-concentration 95% ethanol. This method not only increases the cost of Pueraria decoction, but also uses high-concentration ethanol in the preparation process. is a big security risk
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Embodiment 1
[0026] (1) Preparation of Pueraria decoction extract concentrate
[0027] Pueraria 16kg, Ephedra 8kg, Guizhi 6kg, Radix Paeoniae Alba 6kg, Glycyrrhiza 4kg, Jujube 8kg, Ginger 2kg are pulverized, extracted with 300kg of purified water for 3 hours, and the dregs are added to 200kg of water for extraction for 2 hours, combined The medicinal liquid was extracted twice, and the extracted medicinal liquid was filtered and concentrated to a relative density of 1.14 (boiling test).
[0028] (2) Preparation of Pueraria decoction granules
[0029] Weigh 12g of sodium lauryl sulfate and 500g of stevioside fully dissolved in 60kg of Pueraria decoction concentrate in step (1) as the binder slurry, and weigh 65kg of 120-mesh dextrin and place it in a fluidized bed drying granulator As the substrate, turn on the fan, set the air inlet speed to 35HZ, set the inlet air temperature to 75°C, and start spraying when the temperature of the material reaches 75°C, the slurry is heated to 80°C when ...
Embodiment 2
[0032] (1) Preparation of Pueraria decoction extract concentrate
[0033] The dosage and extraction process of each herb are the same as in Example 1, and the final extracted medicinal liquid is filtered and concentrated to a relative density of 1.18 (boiling test).
[0034] (2) Weigh 20g of sodium lauryl sulfate and 300g of stevioside fully dissolved in 80kg of Pueraria decoction concentrate as the binder slurry, and weigh 30kg of 120-mesh dextrin and place it in a fluidized bed for drying and granulation As the substrate in the machine, turn on the fan, the air inlet speed is 35HZ, set the inlet air temperature to 75°C, and start spraying when the material temperature reaches 75°C, the slurry is heated to 80°C when it is sprayed into the fluidized bed, and the spraying speed is 800- 1200ml / min, keep the air outlet temperature above 38°C, and adjust the air inlet speed appropriately according to the fluidization state of the material.
[0035] (3) After the slurry is sprayed...
Embodiment 3
[0037] Pass the Gegentang granules in Example 2 through a 20-mesh sieve, and fill No. 1 capsules to obtain Gegentang capsules.
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Abstract
The invention relates to a method for preparing puerariae decoction particles, belonging to the technical field of medicine. In a boil drying pelletizing device, the concentrated liquid of a puerariae decoction extract is spayed into a boiling bed and bonded with a boiling excipient and a sweetener to form particles, and the relative density of the puerariae decoction extract is controlled between 1.10 and 1.20, wherein the excipient is one or mixture of a plurality of components with arbitrary proportion of microcrystalline cellulose, starch, pre-gelatinized starch, dextrin, mannitol, lactose and cyclodextrin; and the sweetener is one of components of stevioside, aspartame and acesulfame potassium. The method is simple and feasible, is suitable for mass production, ensures the properties of effective components of puerarin, paeoniflorin and the like and the quality of the gengen decoction particles, reduces the production cost, is safe and reliable, avoids toxic and side effects, and relieves the load of a patient.
Description
technical field [0001] The invention relates to a method for preparing Gegentang granules, which belongs to the technical field of medicine. Background technique [0002] Gegen Decoction comes from "Treatise on Febrile Diseases". It is composed of Pueraria root, ephedra, cinnamon sticks, white peony root, licorice, jujube, and ginger. It can sweat and relieve muscles. It is a common prescription for colds. Gegentang Granules are mainly used for sweating and relieving the exterior surface, promoting body fluids and soothing the meridian, and treating wind-cold and cold. It is used for symptoms such as fever and chills, stuffy nose and runny nose, cough and itchy throat, expectoration with loose white phlegm, sweating, headache and body pain, strong and anxious nape and back, thin white or white and moist fur, floating or tense pulse, etc. Pueraria decoction has a wide range of applications, not limited to colds, but can also be used for the treatment of diseases such as the ...
Claims
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Application Information
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