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Fake medicine discrimination and analysis device, system and method

A technology of discriminant analysis and counterfeit medicine, applied in the field of counterfeit medicine analysis and counterfeit medicine analysis system, to achieve high accuracy, improve detection efficiency and speed, and reduce analysis workload

Inactive Publication Date: 2010-10-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Claims
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Problems solved by technology

[0007] In order to solve the above problems, the applicant once disclosed a drug detection method in the previous application (Application No. CN 2006100288495), which is based on infrared spectroscopy to detect Chinese medicine doped chemicals, but this method fails to solve the above defects, and also Some special situations of portable Raman spectrometers have not been fully considered, so this method cannot be simply applied to the identification of counterfeit drugs

Method used

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  • Fake medicine discrimination and analysis device, system and method
  • Fake medicine discrimination and analysis device, system and method
  • Fake medicine discrimination and analysis device, system and method

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Experimental program
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Embodiment

[0139] 1. Materials and equipment

[0140] 1. Tablet and compound samples: 5 glimepiride tablet samples, 5 glibenclamide tablet samples, negative samples were 4 metformin tablets, sucrose, dextrin, starch, PVPK30, talc, magnesium stearate , Pregelatinized Starch, Carboxymethyl Starch, Hydroxypropyl Cellulose, Lactose, Microcrystalline Cellulose, Hydroxypropyl Methyl Cellulose.

[0141] 2. Counterfeit drug analysis system: the computer hardware system adopts Intel Pentium Dual E2180@2.00GHz chip, calculation software is matlab7.0 (data preprocessing software is OPUS 5.0), and B&WTek i-Raman-785 Raman spectrometer.

[0142] 2. Experimental steps:

[0143] 1. Scrape off the surface coating of the above-mentioned tablets and negative samples, and collect the Raman spectra of the tablets and compounds;

[0144] 2. Carry out wavelet denoising to the original spectra of tablets and compounds (the Raman spectra before and after wavelet transformation are shown in Figure 10 wit...

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Abstract

The invention relates to a fake medicine discrimination and analysis device, a fake medicine analysis system containing the fake medicine discrimination and analysis device and a fake medicine analysis method. The fake medicine analysis method of the invention adopts model-free analysis method, makes an improvement on the basis of the already existing local linear screening method to ensure the method to be more stable and reasonable and combines with major constituent analysis method to form an integral fake medicine discrimination system. The fake medicine discrimination and analysis device, fake medicine analysis system and fake medicine analysis method of the invention only require the spectrum of a compound to be tested and few genuine tablets so as to realize fast and convenient discrimination of the tablets to be tested.

Description

technical field [0001] The invention relates to a device for discriminating and analyzing counterfeit medicines, a counterfeit medicine analyzing system comprising the device for discriminating and analyzing counterfeit medicines, and a method for analyzing counterfeit medicines. Background technique [0002] Counterfeit medicine is one of the common problems faced by countries all over the world, especially developing countries. At present, the phenomenon of manufacturing and selling counterfeit drugs occurs from time to time, resulting in the safety of drugs often cannot be guaranteed, seriously endangering people's health, and disrupting the legitimate and orderly competition in the drug market. Drug sampling inspection is a necessary technical support for drug supervision and management. It is urgent to carry out rapid identification of drugs and improve the ability and work efficiency of identifying counterfeit drugs in grassroots supervision. Of course, due to the cha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 陆峰翁欣欣尹利辉张中湖柴逸峰张学博
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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