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Application of gartanin compound in preparing medicaments for treating hyperlipidemia

A technology for hyperlipidemia and compounds, applied in the field of application of gartanin compounds in the preparation of drugs for the treatment of hyperlipidemia, to achieve strong biological activity and wide application prospects

Inactive Publication Date: 2014-01-15
李平亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, there is no report about the application of gartanin compounds in the preparation of drugs for the treatment of hyperlipidemia

Method used

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  • Application of gartanin compound in preparing medicaments for treating hyperlipidemia
  • Application of gartanin compound in preparing medicaments for treating hyperlipidemia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental example 1. Preliminary test of gartanin in prevention and treatment of hyperlipidemia

[0029] 1 Experimental materials

[0030] animal

[0031]84 ICR mice, 60 males and 24 females, weighing 18-20 g. Purchased from the Animal Experiment Center of Jilin University School of Basic Medicine, animal certificate number: SCXK-(Ji)-2003-0001.

[0032] Drugs and Reagents

[0033] Xuezhikang capsule: specification 300mg / capsule, batch number 20060305, produced by Beijing Beida Weixin Biotechnology Co., Ltd.;

[0034] Fenofibrate group: specification 200mg / capsule, batch number 89396, produced by French Liboforni Pharmaceutical Company;

[0035] Cholesterol: Specification biochemical reagent, 25g / bottle, batch number: 070516, Tianjin Guangfu Fine Chemical Research Institute;

[0036] Sodium cholate: standard biochemical reagent, batch number: 20070525, Beijing Chemical Reagent Company;

[0037] Lard: provided by the laboratory;

[0038] Serum Total Cholestero...

Embodiment 1

[0059] a. Pulverize the flat hazel skin, extract 3 times with 25 times the amount of 95% ethanol at 30°C, each time for 3h, 2h, and 1h, filter, and combine the extracts;

[0060] b. Add the extract obtained in step a, recover the ethanol until it has no alcohol smell, extract with ethyl acetate, and recover the extract to obtain the ethyl acetate extract.

[0061] c. The ethyl acetate extract obtained in step b. is subjected to silica gel column chromatography, the eluent is chloroform-methanol (15-1:1) and petroleum ether-acetone (25-1:1), and the gartanin is collected For the compound part, the solvent was recovered to dryness, and recrystallized from chloroform to obtain a yellow needle crystal product, mp 171-172°C, and the yield was 0.45%.

Embodiment 2

[0063] a. Crush flat hazel skin, extract 3 times with 20 times the amount of 30% ethanol at 80°C, each time for 3h, 2h, and 1h, filter, and combine the extracts;

[0064] b. Add the extract obtained in step a, recover the ethanol until it has no alcohol smell, extract with ethyl acetate, and recover the extract to obtain the ethyl acetate extract.

[0065] c. The ethyl acetate extract obtained in step b. is subjected to silica gel column chromatography, the eluent is chloroform-methanol (15-1:1) and petroleum ether-acetone (25-1:1), and the gartanin is collected For the compound part, the solvent was recovered to dryness, and recrystallized from chloroform to obtain a yellow needle crystal product, mp 171-172°C, and the yield was 0.5%.

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Abstract

The invention relates to application of a gartanin compound in preparing medicaments for treating hyperlipidemia. An extracting and preparing method of the gartanin compound comprises the following steps of: pulverizing corylus heferopuylla peels and extracting by using 20-25 percent of 30-95 percent alcohol at the temperature of 30-80 DEG C; recovering the alcohol until no alcohol taste exists; extracting by using ethyl acetate; and obtaining the gartanin compound through methods of silica column chromatography, recrystallization, and the like. The compound is a raw material medicine for novel medicine research, mp is 171-172 DEG C, and the productivity reaches 0.4-0.5 percent. The gartanin compound can be applied to preparing medicaments for treating hyperlipidemia.

Description

technical field [0001] The present invention relates to the pharmaceutical use of a monomer compound, especially the gartanin compound. Background technique [0002] The Chinese name of gartanin compound is 1,3,5,8-tetrahydroxy-2,4-di(3-methyl-2-butenyl) ketone. It is a monomer compound extracted and isolated from flat hazel bark. [0003] figure 1 is 1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-butenyl) Ketone structure. [0004] Flat hazel (Corylus heterophylla Fisch) is a species of hazel. Hazel (Corylusheterophylla Fish.ex Bess.) is a plant of the genus Corlus (betulaceae) of the betulaceae family. It is native to my country and has a history of more than 6,000 years according to research. Due to the abundant wild resources of hazel, over the years my country has mostly used wild resources. With the rapid development of cultivation and the continuous development of the market, a small amount of cultivation has been carried out in some areas of my country in recent y...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P3/06
Inventor 李平亚刘金平卢丹薛健飞
Owner 李平亚