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Revaprazan hydrochloride nanosuspension and preparation method thereof

A technology of revaprazan hydrochloride and nano-suspension, which is applied in the field of medicine, can solve the problems of large dosage, poor patient compliance, and low bioavailability, achieve long storage time, uniform dispersion, and solve the problem of insoluble water and The effect of low bioavailability

Inactive Publication Date: 2013-03-13
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a newly developed fat-soluble drug, revaprazan hydrochloride is currently only sold in tablets, and because the drug is very slightly soluble in water, resulting in low bioavailability, high dosage, and poor patient compliance

Method used

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  • Revaprazan hydrochloride nanosuspension and preparation method thereof
  • Revaprazan hydrochloride nanosuspension and preparation method thereof
  • Revaprazan hydrochloride nanosuspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 1g of revaprazan hydrochloride, dissolve it in 5ml of absolute ethanol, and pour it into an aqueous solution containing 5g of polyethylene glycol 600, 3g of carboxymethylcellulose sodium and 0.002g of propylparaben under stirring, Heat and stir evenly at 60°C and 100 rpm, evaporate the organic solvent to the utmost, and precipitate the drug crystals to obtain revaprazan hydrochloride nanosuspension.

Embodiment 2

[0024] Weigh 1g of revaprazan hydrochloride, dissolve it in 5ml of absolute ethanol, then pour it into an aqueous solution containing 5g of poloxamer 188, 3g of hydroxypropyl cellulose and 0.0015g of propylparaben, and then place Ultrasonic dispersion was carried out in an ultrasonic cleaner for 30 minutes to precipitate the drug crystals to obtain revaprazan hydrochloride nanosuspension.

Embodiment 3

[0026] Weigh 1g of revaprazan hydrochloride, dissolve it in 5ml of absolute ethanol, pour it into an aqueous solution containing 2g of polyvinylpyrrolidone, 3g of sodium carboxymethylcellulose and 0.001g of sorbic acid under stirring, and then use an ultrasonic cell pulverizer Ultrasonic dispersion was performed 30 times (10 s each time, 8 s off) to precipitate the drug crystals to obtain revaprazan hydrochloride nanosuspension.

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Abstract

The invention discloses revaprazan hydrochloride nanosuspension and a preparation method thereof, belonging to the technical field of medicines. Revaprazan hydrochloride is a novel proton pump inhibitor and makes an effect of potentially inhibiting basal gastric acid secretion, but in-vivo bioavailability is low due to medicinal slight dissolution. By adopting a nano technology, the particle size of a medicine is reduced to prepare the nano-suspension and evaluate the in-vitro dissolution and the in-vivo bioavailability of the nano-suspension of the medicine. A determining result shows that the nano-suspension can greatly improve the dissolution and the bioavailability of the medicine. The invention further discloses the preparation method of the nano-suspension.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a revaprazan hydrochloride nano-suspension and a preparation method thereof. Background technique [0002] Peptic ulcer is a common disease, the incidence rate will be different in different periods and regions, and the incidence rate usually accounts for about 10-20% of the total population. At present, with social development, environmental changes, and changes in people's lifestyles, the incidence of peptic ulcers caused by smoking, drinking, emotional stress, and drug stimulation is gradually increasing, which is seriously affecting people's work and life. The exact pathogenesis of it is still unclear in the medical community, but the inhibition of gastric acid secretion has become the first choice for the treatment of such diseases. [0003] Revaprazan hydrochloride is a new type of reversible proton pump inhibitor developed by South Korea Yuhan Company. Compared with tradit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/506A61P1/04
Inventor 方亮李炜
Owner SHENYANG PHARMA UNIVERSITY
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