Application of gastrin in inhibiting gastrointestinal tumor tumors

Abstract

The invention discloses a novel application of gastrin in inhibiting gastrointestinal tumor tumors. Gastric cancer target gene anion exchange protein 1 is interacted with tumor suppressor protein p16 so as to induce gastric cancer, however, 17 peptide gastrin (H-pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) can effectively inhibit expression of gastric cancer target gene AE1 and p16 and breaks through the traditional view that gastrin induces tumors, and clinical pathologies show that the gastrin has obvious negative correlation with AE1 and p16. The invention alsodiscloses that the gastrin with the concentration of 10-10mol / L-10-70mol / L has obvious inhibition effect on gastric cancer cell activity after a certain time, thus prompting that the gastrin has curing effect on gastric antrum cancer and providing a new direction for curing gastric cancer based on the test results.

Description

technical field

[0001] The invention relates to the fields of molecular biology, cell biology and pharmacology, and more specifically, relates to a new application of gastrin. Background technique

[0002] Gastric cancer ranks fourth among all malignant tumors in new cases each year, and ranks second among all causes of death due to tumors. There are approximately 1,000,000 gastric cancer cases and more than 850,000 deaths per year, and early diagnosis of gastric cancer Difficult, the 5-year survival rate is only 20%. The pathogenesis of gastric cancer has made progress in many aspects in recent years, including Helicobacter pylori infection, environmental factors, gene mutation and so on. Gastrin is a polypeptide hormone that is mainly secreted by G cells in the gastrointestinal tract and specifically binds to gastrin receptors. A large number of studies have shown that gastrin not only stimulates gastric acid secretion and has nutritional effects on gastrointestinal mucos...

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