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Sustained-release composition of cefaclor
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A composition and cephalosporin technology, which is applied in the directions of drug delivery, medical preparations with inactive ingredients, and pharmaceutical formulations, etc., can solve the problems of affecting the curative effect and long time of complete release, etc.
Active Publication Date: 2015-04-22
ZHEJIANG ANGLIKANG PHARMA
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The disadvantage of this patent is that the complete release time is too long, which affects the curative effect
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Embodiment 1
[0020] Raw materials (g)
[0021] Take cefaclor, sodium carboxymethyl cellulose, mannitol, povidone (K30), hypromellose (E5), and microcrystalline cellulose, sieve and mix well, and use 5% polyacrylic acid resin II ethanol solution Soft material, 16-mesh granulation, drying, 12-mesh granulation, adding magnesium stearate, mixing, tableting.
Embodiment 2
[0023] Raw materials
[0024] Take cefaclor, sodium carboxymethylcellulose, mannitol, hypromellose (K100M), and stearic acid, sieve and mix well, use 5% polyacrylic resin II ethanol solution to make soft material, and granulate with 16 mesh , dried, 12-mesh granules, added magnesium stearate, mixed evenly, and compressed into tablets.
Embodiment 3
[0026] Raw materials
[0027] Take cefaclor, sodium carboxymethylcellulose, sucrose, hypromellose (E5), hypromellose (100M) and stearic acid, sieve and mix thoroughly, and use 5% polyacrylic acid resin II ethanol solution Soft material, 16-mesh granulation, drying, 12-mesh granulation, adding magnesium stearate, mixing, tableting.
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Abstract
The invention relates to the technical field of drug release, in particular to a novel sustained-release composition of cefaclor. The sustained-release composition of cefaclor comprises 60-90% of cefaclor, 5-25% of water-soluble adhesives, 0.5-5% of water-insoluble retardants, 2-10% of porogenic agents and 2-15% of cellulose derivatives with water viscosity being more than 500mmPa.s by total weight of the composition. The sustained-release composition of cefaclor can be completely released within 4-8h, has sustained-release effect in bodies and is applicable to administration twice a day.
Description
Technical field [0001] The invention relates to the technical field of drug release, in particular to a novel slow-release composition of cefaclor. Background technique [0002] The half-life of many oral β-lactam antibiotics is very short. For example, the half-life of cefaclor in vivo is only 0.6 to 0.9 hours. Common cefaclor preparations are administered three or four times a day to achieve the therapeutic purpose. Too many times of administration caused many troubles for the patient, and therefore it was necessary to develop a preparation with fewer times of administration. [0003] Chinese patent CN99806823.3 discloses an effervescent intragastric floating preparation of cefaclor, which includes a swelling polymer and a gas-generating salt in addition to the main drug, and can release the medicine within 20 hours. The embodiment that released in a short time (4-8 hours). However, the effervescent intragastric floating preparation produces a large amount of gas in the ...
Claims
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Application Information
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