Method for detecting medicine composition for warming spleen and tonifying kidney and releasing turbidity and eliminating stasis

A technology for releasing turbidity, removing blood stasis, and testing methods, which can be applied to drug combinations, medical formulas, measuring devices, etc., and can solve the problems of no quality testing methods, inconvenient decoction and large dosage, etc.

Inactive Publication Date: 2010-12-01
BEIJING SIHUAN KEBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

) is one of the most effective prescriptions for the clinical treatment of CRF at present. The preparation adopts water decoction at present, which is inconvenient to decoct and take, with many losses of volatile components and large dosage, and there is no corresponding quality

Method used

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  • Method for detecting medicine composition for warming spleen and tonifying kidney and releasing turbidity and eliminating stasis
  • Method for detecting medicine composition for warming spleen and tonifying kidney and releasing turbidity and eliminating stasis
  • Method for detecting medicine composition for warming spleen and tonifying kidney and releasing turbidity and eliminating stasis

Examples

Experimental program
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Effect test

Embodiment 1

[0134] Example 1: Granules and Detection Method

[0135] 600g rhubarb, 360g aconite (prepared), 240g dried ginger, 240g ginseng, 120g licorice

[0136] Preparation method: add 25 times the amount of water for the above five flavors, dry ginger, soak for 16 hours, distill for 6 hours, extract the volatile oil, centrifugally filter the distillate, and collect the filtrate in another device; use 7 times the amount of medicinal residues, rhubarb, aconite, ginseng, and licorice Soak in 70% ethanol for 16 hours, heat and reflux for extraction 3 times, add 6 times the amount of 70% ethanol for the second and third times, extract for 2 hours each time, filter while hot, recover ethanol from the filtrate until there is no alcohol smell, and extract the ethanol after distillation. The aqueous solutions were combined, concentrated to a relative density of 1.22-1.25 (50°C), added with 200 g of microcrystalline cellulose, mixed well, dried into dry extract, and pulverized into fine powder ...

Embodiment 2

[0145] Embodiment 2: Granules and detection method

[0146] 600g rhubarb, 360g aconite (prepared), 240g dried ginger, 240g ginseng, 120g licorice

[0147]Preparation method: add 25 times the amount of water for the above five flavors, dry ginger, soak for 16 hours, distill for 6 hours, extract the volatile oil, centrifugally filter the distillate, and collect the filtrate in another device; use 7 times the amount of medicinal residues, rhubarb, aconite, ginseng, and licorice Soak in 70% ethanol for 16 hours, heat and reflux for extraction 3 times, add 6 times the amount of 70% ethanol for the second and third times, extract for 2 hours each time, filter while hot, recover ethanol from the filtrate until there is no alcohol smell, and extract the ethanol after distillation. The aqueous solutions were combined, concentrated to a relative density of 1.22-1.25 (50°C), added with 200 g of microcrystalline cellulose, mixed well, dried into dry extract, and pulverized into fine powde...

Embodiment 3

[0153] Embodiment 3: Detection method

[0154] The medicinal composition for warming the spleen and invigorating the kidney, removing turbidity and removing blood stasis is prepared by the method of Example 2.

[0155] A. Take the medicinal composition equivalent to 15.6 g of the original medicinal material for warming the spleen and nourishing the kidney, removing turbidity and removing blood stasis, adding 50 ml of 45% ethanol solution of 7% sulfuric acid, ultrasonically treating it for 20 minutes, filtering with filter cloth, and placing the filtrate in a conical flask , the water bath was refluxed for 2 hours, filtered with filter cloth, the filtrate was extracted three times with 60-90 ℃ petroleum ether, 20 ml each time, the extracts were combined, and 0.1 mol / L sodium hydroxide solution was added to wash until there was no pink color, and then washed with water To neutrality, the ether layer was evaporated to dryness, and the residue was dissolved in methanol to make 0.5...

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Abstract

The invention relates to a method for detecting medicine composition for warming the spleen and tonifying the kidney and releasing turbidity and eliminating stasis. The method includes content determination and identification methods or detection of limited quantity of aconitine. In the content determination method, the high performance liquid chromatography is adopted. The detection method of the invention also includes identification of ginseng, liquorice and rhizoma zingiberis and detection of aconitine. The detection method of the invention features good specificity, high stability, good repeatability and high precision, thus being more suitable for industrialized production and ensuring safe, effective and reliable clinical medication. In addition, the preparation prepared by the alcohol extraction method has better effect.

Description

technical field [0001] The invention relates to a detection method of a traditional Chinese medicine composition, in particular to a quality detection method of a medicinal composition for warming the spleen and benefiting the kidney, releasing turbidity and removing blood stasis. Background technique [0002] Chronic renal failure (CRF for short) is a serious syndrome caused by the development of various chronic kidney diseases to an advanced stage. It belongs to the category of diseases such as "addiction", "deficiency tuberculosis" and "off grid" in traditional Chinese medicine. According to foreign statistics, the annual incidence rate is 100-150 people / 1 million. According to the survey of 2 million urban population in my country, 568 people / 1 million have end-stage renal failure. Among patients with kidney disease, older age is more prone to renal insufficiency. With the aggravation of the aging population in our country, the incidence of the disease is gradually inc...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P13/12G01N30/02G01N30/90
Inventor 张建立曹相林于文占褚清宗熊胜辉高万峰
Owner BEIJING SIHUAN KEBAO PHARM CO LTD
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