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In vivo isotopic labeling method for quantitative glycomics

A technique for glycans and samples, applied in the field of high-throughput quantitative/comparative analysis of glycomics compositions

Inactive Publication Date: 2010-12-08
UNIV OF GEORGIA RES FOUND INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

O-linked glycans are usually released from protein backbones by β-elimination and are therefore not suitable for these methods

Method used

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  • In vivo isotopic labeling method for quantitative glycomics
  • In vivo isotopic labeling method for quantitative glycomics
  • In vivo isotopic labeling method for quantitative glycomics

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Embodiment Construction

[0045] The following terms are used to define the present invention. To the extent a term is not specifically defined herein, the term shall be accorded the meaning that one of ordinary skill in the art would use in the context in which one or more aspects of the invention are used.

[0046] Unless otherwise stated, terms used herein are to be understood as conventional usage by those of ordinary skill in the relevant art. In addition to the definitions of terms provided below, definitions of terms commonly used in molecular biology and biochemistry may also be used, see for example Rieger et al., 1991 Glossary of genetics: classical and molecular, 5th Ed., Berlin: Springer-Verlag; and Current Protocols in Molecular Biology, F.M. Ausubel et al., Eds., Current Protocols, a joint venture between Greene Publishing Associates, Inc. and John Wiley & Sons, Inc., (1998 supplement). It should be understood that as used in the specification and claims, "a" or "an" can mean one or more...

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Abstract

The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative / comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and / or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.

Description

field of invention [0001] The present invention relates to isotope labeling of glycans and methods to facilitate high-throughput quantitative / comparative analysis of glycomic compositions of biological cells. [0002] Priority Claims and Funding Support [0003] This application claims priority to U.S. Provisional Application Serial No. 61 / 000,920, filed October 29, 2007, entitled "IDAWG A novel quantitative method for glycomics-IDAWG," the entire contents of which are hereby incorporated by reference in their entirety. [0004] This invention was made with Government support under grant numbers NIH / NCRR 5P41RR018502 and NIH / NIDDK 1R01DK075069 awarded by NIH. Accordingly, the US Government has certain rights in this invention. Background of the invention [0005] A series of strategies have been developed for high-throughput quantitative / comparative analysis of large-scale systems, so that expression levels of various molecules can be compared between different biological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/534G01N33/48G01N33/68G01N33/532
CPCG01N2400/12G01N33/6848G01N2458/15G01N33/502G01N2400/38G01N2400/00
Inventor 罗伯特·L·韦尔斯罗纳德·C·奥兰多斯蒂芬·达尔顿凯利·W·莫雷曼J·迈克尔·皮尔斯詹姆斯·A·阿特伍德迈克尔·蒂迈耶威廉·S·约克
Owner UNIV OF GEORGIA RES FOUND INC
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