High fluoride ion recovery compositions

一种组合物、回收率的技术，应用在药物组合、牙科、消化系统等方向，能够解决可利用氟离子减少等问题

Active Publication Date: 2011-02-16
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ionic salts, including fluoride, are known to interact and become trapped in various polymers causing a reduction in available fluoride

Method used

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  • High fluoride ion recovery compositions
  • High fluoride ion recovery compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Five dentifrice compositions were prepared, formulated to achieve a theoretically available fluoride ion concentration of 5,000 ppm. The ingredients of the compositions are shown in Table 1.

[0061] Table 1

[0062]

[0063] Compositions X, A and B form a paste suitable as toothpaste. Composition C was found to form a paste suitable as toothpaste. Composition D was found not to form a paste useful as a dentifrice composition.

Embodiment 2

[0065] Compositions X, A and B were used by volunteers and found to have a "smooth" feel. After using Composition C, volunteers found the composition to have a "smooth" feel in the mouth.

Embodiment 3

[0067]Compositions X, A, B and C were tested for fluoride ion availability when initially prepared, after 3 months of accelerated aging (at 40°C and 75% relative humidity), and after 6 months of accelerated aging . The results are provided in Table 2.

[0068] Table 2

[0069]

[0070] The results show that compositions lacking xanthan gum, pectin and PVME / MA copolymer suffer an immediate loss of fluoride ion availability. For Compositions A and C, the initial fluoride ion availability after preparation was unacceptable (less than 90%); therefore, no aging studies were performed on Compositions A and C. Composition B continued to lose available fluoride ions over time. Surprisingly, Composition X maintained a complete and complete amount of available fluoride even after 6 months of aging.

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Abstract

Compositions having high fluoride ion recovery comprising a hydrocolloid, a heteropolysaccharide, a PVME / MA copolymer, and a fluoride ion source and use thereof, e.g., in the treatment of xerostomia and / or sensitive teeth.

Description

Background of the invention [0001] Dental caries is the major dental disease affecting most of the population. In the early twentieth century, investigators found that fluoride was effective in reducing the incidence of dental caries. Fluoride research has been conducted since then, and it is now well accepted that fluoride treatments are beneficial to dental health. [0002] Most dentifrice compositions contain fluoride ions in the range of 1,000 to 1,500 ppm. However, for some populations, higher amounts of fluoride may even be beneficial. Some patients frequently suffer from aggressive caries, or are otherwise at higher risk of tooth decay than the general population. Other patients suffer from xerostomia or tooth sensitivity. These patients may benefit from specialized dentifrices that incorporate high levels of fluoride ions. For example, some such dentifrices incorporate sodium fluoride as a source of fluoride ions in amounts in excess of 1,500 ppm, such as about 2,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q11/00A61K8/21A61K8/81A61K8/73
CPCA61K8/65A61K8/8164A61Q11/00A61K8/737A61K8/21A61K8/73A61P1/02
Inventor M·乔齐亚克J·内斯塔
Owner COLGATE PALMOLIVE CO
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