Caffeic acid p-nitrophenyl ethyl ester as well as preparation method and application of caffeic acid p-nitrophenyl ethyl ester

Abstract

The invention belongs to the fileds of chemistry and pharmacy, in particular to caffeic acid p-nitrophenyl ethyl ester of which the structural formula is as shown in formula I. The caffeic acid p-nitrophenyl ethyl ester has the effect of increasing leukocytes, can obviously increase the number of the peripheral blood leukocytes of mice with immunosuppression caused by cyclophosphamide, can be used for preparing medicaments for increasing the white blood cells, plays an important role in treating leukopenia after radiochemotherapy on malignant tumors and possibly has a good curative effect on the leukopenia caused by other pathogenic factors. The invention also provides a preparation method of the caffeic acid p-nitrophenyl ethyl ester, which comprises the following steps: heating caffeic acid and thionyl chloride in a polar organic solvent to carry out a refluxing reaction so as to generate caffeic acid acyl chloride, adding p-nitrophenyl ethanol, continuing to heat to carry out the refluxing reaction so as to generate the caffeic acid p-nitrophenyl ethyl ester, and finally separating and purifying by column chromatography to obtain pure caffeic acid p-nitrophenyl ethyl ester. Themethod has the advantages of high yield and low cost, is convenient to operate and the like.

Description

technical field The invention relates to the fields of chemistry and pharmacy, in particular to a new compound, a preparation method of the compound and an application of the compound in pharmacy. Background technique When the number of white blood cells in peripheral blood is continuously lower than 4×10 9 / L is called leukopenia. Leukopenia is a disease caused by unknown causes and secondary to other diseases. It is divided into two types: primary and secondary: the primary cause is unknown; the secondary cause is acute infection, physical and chemical factors, blood Systemic diseases, diseases with splenomegaly, connective tissue diseases, allergic diseases, genetic diseases, acquired or unexplained neutropenia, etc. Leukopenia is a common complication in malignant tumors, especially in patients undergoing radiotherapy and chemotherapy. Because radiation and drugs inhibit bone marrow hematopoietic function, leukopenia is often caused. At present, the treatment of leuko...

AI Technical Summary

Problems solved by technology

It mainly has the following problems: the curative effect of the existing leukocyte-increasing drugs is not sure; while component blood transfusion and hematopoietic stimulating factors are effective, but the action time is short, easy to repeat, side effects are obvious, and the price is expensive, and the financial burden on patients is relatively large

Caffeic acid phenethyl ester (CAPE) is a main active component in propolis, which has anti-tumor, anti-oxidation, anti-inflammation, immune regulation and other pharmacological effects, but whether it can increase white blood cells has not been published at home and abroad to report

Images