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MiR-125a for adjusting regulated on activation normal T cell expressed and secreted (RANTES) expressions as well as composition and application thereof

A technology of 1. mir-125a, application, applied in the field of miR-125a, can solve the problems such as no related reports

Active Publication Date: 2013-03-13
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the relationship between miRNA and SLE inflammatory response has not been reported so far.

Method used

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  • MiR-125a for adjusting regulated on activation normal T cell expressed and secreted (RANTES) expressions as well as composition and application thereof
  • MiR-125a for adjusting regulated on activation normal T cell expressed and secreted (RANTES) expressions as well as composition and application thereof
  • MiR-125a for adjusting regulated on activation normal T cell expressed and secreted (RANTES) expressions as well as composition and application thereof

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Embodiment Construction

[0035] The present invention relates to the treatment of RANTES mediated diseases.

[0036] RANTES is a typical C-C subfamily member inflammatory chemokine, which can aggravate arthritis, atopic dermatitis, nephritis, colitis and other diseases [21]. In addition, the receptor CCR5 of RANTES is a co-receptor for HIV to enter target cells, and plays an important role in the process of HIV virus fusion and entry into target cells. As a drug target, RANTES has become a hotspot in the research and development of new drugs for diseases such as chronic inflammation, alleviating transplant rejection, and HIV infection.

[0037] Therefore, the "RANTES-mediated diseases" mentioned in the present invention may include various chronic inflammations, alleviating transplant rejection, HIV infection and other diseases. In specific embodiments, the "RANTES-mediated diseases" in the present invention include arthritis, atopic dermatitis, nephritis, colitis, systemic lupus erythematosus, lupus...

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Abstract

The invention provides the use of miR-125a for manufacturing the substance for treating the diseases mediated by inflammatory chemokine RANTES, the pharmaceutical composition comprising miR-125a, the method for regulating expression of RANTES in tissues or cells using miR-125a in vitro, and the method for screening the substance with capability of regulating the expression of RANTES.

Description

technical field [0001] The present invention relates to miR-125a regulating the expression of RANTES, its composition and its use. Background technique [0002] Systemic lupus erythematosus (SLE) is a common chronic inflammatory autoimmune disease involving multiple organs. The mechanism is not yet clear, and inflammation is the main pathological change [1]. The current treatment is mainly non-specific inflammation inhibitors such as glucocorticoids and immunosuppressants. There is still a lack of specific treatment methods, which cannot fundamentally improve the level of disease prevention and treatment[2]. [0003] At present, a large number of related studies have reported that inflammatory chemokines play an important role in the pathogenesis of SLE [11-14], especially in the pathogenesis of nephritis. RANTES is a typical inflammatory chemokine of members of the C-C subfamily, which induces T cells, dendritic cells, eosinophils and other immune cells to infiltrate into...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61P29/00A61P37/06A61P31/18A61P19/02A61P37/02A61P13/12C12N15/85C12Q1/68
CPCA61K31/7105C12Q2600/178C12Q1/6883C12Q2600/158C12Q2600/136A61P13/12A61P19/02A61P29/00A61P31/18A61P37/02A61P37/06
Inventor 沈南唐元家赵遐曲波崔慧娟王树军
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI