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Medicament for treating coronary heart disease and preparation thereof

A coronary heart disease and drug technology, applied in the field of drugs for the treatment of coronary heart disease, can solve the problems of low bioavailability, inability to meet the emergency needs of patients with angina pectoris, and low content of active ingredients

Active Publication Date: 2011-04-27
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production technology of ordinary tablets and capsules is backward, the content of active ingredients is low, and there is no quality control index. It needs to be taken orally and absorbed through the gastrointestinal tract, and absorbed after the first-pass effect in the liver. Into the blood, low bioavailability, slow absorption. It is not suitable for the first aid needs of patients with angina pectoris

Method used

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  • Medicament for treating coronary heart disease and preparation thereof
  • Medicament for treating coronary heart disease and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 The preparation of the drug drop pill for the treatment of coronary heart disease, each component is made up of the weight percent of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 82.87%, Radix Notoginseng 16.21%, Borneol 0.92%;

[0061] Step 1: add 3 times the amount of 95% ethanol to Danshen and Panax notoginseng, extract under reflux for 2 hours, and filter; add 2 times the amount of 95% ethanol to the dregs, extract under reflux for 1 hour, filter, concentrate the extract under reduced pressure, and dry to obtain Salvia miltiorrhiza Seven 95% alcohol extract;

[0062] Step 2: Add 8 times the amount of PH7-8 alkaline water for the first time to decoct the dregs of Danshen notoginseng after ethanol extraction in step 1 for 2 hours, and add 8 times the amount of water to decoct for 1 hour for the second time to obtain the extract , concentrate the extract, add ethanol until the alcohol content of the medicinal solution is 60%-70...

Embodiment 2

[0064] Embodiment 2 The preparation of the medicine dripping pill for the treatment of coronary heart disease, each component is made up of the weight percentage of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 19.8%, Radix Notoginseng 78.2%, Borneol 2%;

[0065] Step 1: add twice the amount of 85% ethanol to Danshen and Panax notoginseng, reflux extraction once, for 1 hour each time, filter, concentrate the extract under reduced pressure, and dry to obtain 85% alcohol extract of Danshen notoginseng;

[0066] Step 2: Add 7 times the amount of PH7-8 alkaline water for the first time to decoct the dregs of Danshen notoginseng after ethanol extraction in step 1, and add 6 times the amount of water to decoct for 1 hour for the second time to obtain the extract , concentrate the extract, add ethanol until the alcohol content of the medicinal solution is 60%-70%, let it stand for more than 12 hours, separate the supernatant, recover the ethanol, collect th...

Embodiment 3

[0068] Embodiment 3 The preparation of the drug drop pill for the treatment of coronary heart disease, each component is composed of the weight percentage of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 97%, Panax notoginseng 2%, Borneol 1%;

[0069] Step 1: add 5 times the amount of 95% ethanol to Danshen and Panax notoginseng, reflux extraction for 3 times, each time for 3 hours, filter, concentrate the extract under reduced pressure, and dry to obtain 95% alcohol extract of Danshen notoginseng;

[0070] Step 2: Add 6 times the amount of alkaline water with a pH of 7-8 to decoct for 3 hours the first time, add 6 times the amount of water to decoct for 2 hours to obtain the extract, extract Concentrate the liquid, add ethanol until the alcohol content of the medicinal liquid is 60%-70%, let it stand for more than 12 hours, separate the supernatant, recover the ethanol, collect the paste to a sugar content of 70%-75%, and obtain the extract of Dansh...

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Abstract

The invention relates to a medicament for treating coronary heart disease and a preparation method thereof. The preparation method comprises the steps of ethanol extraction of root of red rooted salvia and root of pseudo-ginseng, water extraction of the decoction dregs of the root of red rooted salvia and the root of pseudo-ginseng, and the like. The process can realize industrialization, and the quality is stable and controllable. Related experiments show that: the medicament has high curative effect compared with the prior art; the medicament has high purity, good absorption, stable quality and novel application; and meanwhile, the preparation method is simple and convenient for operation, has low cost, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a medicine for treating coronary heart disease, which belongs to the field of traditional Chinese medicine. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [0003] The current methods of treating angina pectoris mainly focus on dilating blood vessels, reducing blood viscosity, anti-platelet aggregation, and anti-coag...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 刘顺航徐波戚可人刘岩陈红丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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