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Ganoderma sinense mycelium polysaccharide refined substance as well as preparation method and use thereof

A technology of mycelium polysaccharides and Zizhi, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems that do not involve polysaccharide molecules, polysaccharides, monosaccharides, etc., and achieve obvious anti-tumor activity and dosage The effect of small, high polysaccharide content

Inactive Publication Date: 2013-09-11
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the above patents and articles involve research on the molecular weight of polysaccharides and the composition of polysaccharides and monosaccharides

Method used

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  • Ganoderma sinense mycelium polysaccharide refined substance as well as preparation method and use thereof
  • Ganoderma sinense mycelium polysaccharide refined substance as well as preparation method and use thereof
  • Ganoderma sinense mycelium polysaccharide refined substance as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Crude polysaccharide extraction:

[0061] Ganoderma sinense was used for liquid fermentation to obtain 1300 L of fermentation broth, the obtained mycelium was washed with water, and plate-and-frame filter press was performed. The mycelium was extracted twice with 3 times of water and heated for 3 hours each time, and the extraction temperature was 90°C. The water extracts were combined and concentrated until the ratio of the amount of mycelium to the amount of medicinal solution was 1:2, and then 4 times of 95% alcohol was added to precipitate overnight, and the precipitate was taken out and dried to obtain 119.22 g of crude polysaccharide.

[0062] The polysaccharide content of the crude polysaccharide measured by the phenol sulfuric acid method was 34.9%.

[0063] Crude polysaccharide refining:

[0064] Take the above crude polysaccharide and dissolve it in 20 times of water, separate the crude polysaccharide solution with an ultrafiltration membrane with a molecula...

Embodiment 2

[0068] Crude polysaccharide extraction:

[0069] Ganoderma sinense was used for liquid fermentation to obtain 1300 L of fermentation broth, the obtained mycelium was washed with water, and plate-and-frame filter press was performed. The mycelium was extracted with 3 times of water and heated for 3 times, each time for 2 hours, and the extraction temperature was 80°C. The water extracts were combined and concentrated until the ratio of the amount of mycelium to the amount of medicinal solution was 2:1, and then added 3 times of 85% alcohol to precipitate overnight, and the precipitate was taken out and dried to obtain 144.46 g of crude polysaccharide.

[0070] The polysaccharide content of the crude polysaccharide measured by the phenol sulfuric acid method was 42.8%.

[0071] Crude polysaccharide refining:

[0072] Take the above crude polysaccharide and dissolve it in 20 times of water, separate the crude polysaccharide solution with an ultrafiltration membrane with a molec...

Embodiment 3

[0076] Crude polysaccharide extraction:

[0077] Ganoderma sinense was used for liquid fermentation to obtain 1300 L of fermentation broth, the obtained mycelium was washed with water, and plate-and-frame filter press was performed. The mycelium was extracted with 3 times of water and heated for 3 times, each time for 2 hours, and the extraction temperature was 80°C. The water extracts were combined and concentrated until the ratio of the amount of mycelium to the amount of medicinal solution was 2:1, and then added 3 times of 85% alcohol to precipitate overnight, and the precipitate was taken out and dried to obtain 144.46 g of crude polysaccharide.

[0078] The polysaccharide content of the crude polysaccharide measured by the phenol sulfuric acid method was 42%.

[0079] Crude polysaccharide refining:

[0080] The above crude polysaccharide was dissolved in 20 times of water, the crude polysaccharide liquid was separated by an ultrafiltration membrane with a molecular wei...

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Abstract

The invention provides a ganoderma sinense mycelium polysaccharide refined substance containing polysaccharide and monosaccharide; the polysaccharide refined substance is characterized in that the content of the polysaccharide is greater than 90% and the content of the monosaccharide is smaller than 5%. The invention also provides a preparation method and use of the ganoderma sinense mycelium polysaccharide refined substance. The ganoderma sinense mycelium polysaccharide refined substance provided by the invention has the advantages of higher polysaccharide content, lower administration dose, centralized molecular weight range and higher purity; and the preparation technology of the ganoderma sinense mycelium polysaccharide refined substance is suitable for industrial production.

Description

technical field [0001] The invention relates to a refined mycelia polysaccharide of Zizhi lucidum, its preparation method and its application in the field of medicine. Background technique [0002] Edible and medicinal fungi have various functions such as anti-tumor and anti-virus, lowering blood lipids, delaying aging, protecting the liver and detoxifying, promoting nucleic acid and protein biosynthesis, etc., and have a long history of use in China. A large number of studies at home and abroad have shown that fungal polysaccharides are isolated from fungal fruiting bodies, mycelia, and fermentation broths. They are the active parts of fungal drugs, and they are a type of active polysaccharides that can control cell division and differentiation, and regulate cell growth and aging. . [0003] Ganoderma (Ganoderma Sinense Zhao, Xu et Zhang) is a higher fungus belonging to Basidiomycetes, Polyporaceae, Polyporaceae, Ganoderma genus. Beneficial to joints, protects the mind, n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/00C08K5/07C08B37/00A61K31/715A61P35/00A61P37/04
Inventor 杨义芳金隽迪杨国红
Owner SHANGHAI INST OF PHARMA IND CO LTD
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