Material for preparing expandable artificial eye table and application thereof

A technology of prosthetic eye platform and inorganic nanoparticles, which is applied in the field of materials for the preparation of expandable prosthetic eye platform, to achieve the effects of improving mechanical strength, improving biocompatibility, and reducing surgical pain

Inactive Publication Date: 2011-05-11
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Correcting anophthalmia or microphthalmia in children is considerably more challenging than in adults

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Acrylic acid aqueous solution with a mass fraction of 20%, neutralized with NaOH, the neutralization degree is 80%, and after stirring evenly, add TiO with a mass ratio of 5% 2 Nanoparticles, then add 0.5% N,N'-methylenebisacrylamide and 0.5% potassium persulfate of acrylic acid mass, 2 or fail N 2 Stir the mixed liquid evenly under the same conditions and pour it into the spherical mold. Put the mold at 60 oC for 1 hour to get the jelly. Prosthetic eye platform.

Embodiment 2

[0024] Example 2: The mass fraction is 30% acrylic acid aqueous solution, neutralized with NaOH, the neutralization degree is 80%, after stirring evenly, add mass ratio is 7% TiO 2 Nanoparticles, then add 0.5% N,N'-methylenebisacrylamide and 0.5% potassium persulfate of acrylic acid mass, 2 or fail N 2 Stir the mixed liquid evenly under the same conditions and pour it into the spherical mold. Put the mold at 60 oC for 1 hour to get the jelly. Prosthetic eye platform.

Embodiment 3

[0025] Example 3: The mass fraction is 30% acrylic acid aqueous solution, neutralized with NaOH, the neutralization degree is 70%, after stirring evenly, add mass ratio is 5% TiO 2 Nanoparticles, then add 0.5% N,N'-methylenebisacrylamide and 0.5% potassium persulfate of acrylic acid mass, 2 or fail N 2 Stir the mixed liquid evenly under the same conditions and pour it into the spherical mold. Put the mold at 60 oC for 0.5h to get the jelly. Inflatable eye prosthesis.

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Abstract

The invention relates to a material for preparing an expandable artificial eye table and application thereof. The material comprises the following components in percentage by mass: 10 to 50 percent of acrylic monomers, 0 to 15 percent of inorganic nano particles, 0.1 to 1 percent of cross linker, 0.1 to 1 percent of free radical initiator and the balance of water. The material overcomes the defect of insufficient mechanical strength of a single high water absorption material; and by introducing the inorganic nano particles with good biocompatibility, the mechanical strength of the composite material is improved, the expansion rate of the material is reduced, and the expandable artificial eye table with controllable mechanical strength and expansion rate is prepared. The compression strength of the expandable artificial eye table is 0.1 to 5MPa, the compression modulus is 0.1 to 10MPa, the volume expansion rate in water is 40 to 200 percent, the volume expansion rate in physiological saline is 5 to 80 percent, and the expansion balancing time is 1 to 5 days.

Description

technical field [0001] The invention relates to a material for preparing an expandable artificial eye platform and its application. Background technique [0002] The prosthetic eye table is a kind of eye socket filler, which is mainly used for plastic repair after eyeball enucleation. Clinically, the incidence rate of congenital microphthalmia is 1.2-1.8 / 10000; the incidence rate of congenital anophthalmia is 0.2-0.6 / 10000; enucleation, enucleation of eye contents and atrophy of eyeball caused by other reasons during development, although the clinical The incidence rate is small, but it can also lead to developmental retardation of the orbit; acquired anophthalmia due to ocular tumors, whether it is enucleation or radiation therapy, will retard the development of the orbitofacial face in children, resulting in orbital volume development Incomplete, forming facial deformities. Therefore, the research on prosthetic eye platform can bring hope for the treatment of patients wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16
Inventor 周涓马晓晔魏锐利金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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