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Application of 3',4-dyhydroxyl-3,5'-dimethoxybibenzyl in preparing medicaments for treating cataract

A technology of dimethoxybibenzyl and dihydroxy, which is applied in the field of drugs containing bibenzyl compounds, and can solve problems such as unsatisfactory effects

Inactive Publication Date: 2012-02-22
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned therapeutic drugs can only delay the occurrence and development of the disease; the effect is still unsatisfactory

Method used

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  • Application of 3',4-dyhydroxyl-3,5'-dimethoxybibenzyl in preparing medicaments for treating cataract
  • Application of 3',4-dyhydroxyl-3,5'-dimethoxybibenzyl in preparing medicaments for treating cataract
  • Application of 3',4-dyhydroxyl-3,5'-dimethoxybibenzyl in preparing medicaments for treating cataract

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] The preparation of example 1Gigantol

[0016] The Gigantol extraction method is a prior art, and the inventor refers to the literature (Zhang Chaofeng, Shao Li, Wang Lei, etc. Research on the chemical constituents of Dendrobium dendrobii [J] Chinese Journal of Traditional Chinese Medicine, 2008, 33 (24): 2922~2925. Yang Li, Gu Lihua, Wang Zhengtao, et al. Qualitative and quantitative analysis of bibenzyl components in Dendrobium sheath [J] Chinese Journal of Pharmaceutical Sciences, 2007, 42(21): 1620-1623.) report on preparation of gigantol, specific implementation process as follows:

[0017] Dried Dendrobium nobile, chopped into coarse powder, heated and refluxed with 95% ethanol to extract 2 to 3 times, the amount of ethanol added each time was 12000ml / kg of medicinal material, refluxed for about 2 hours, combined with the medicinal liquid, suction filtered, and the filtrate was concentrated to There is no ethanol smell, and the extract is obtained, which is suspe...

example 2

[0020] Example 2 Eye Drops 1

[0021] (1) Prescription:

[0022] Gigantol 3.00g

[0023] Borax 5.72g

[0024] Boric acid 7.98g

[0025] Ethyl p-hydroxybenzoate 0.26g

[0026] Sodium chloride 7.35g

[0027] Add water for injection to 1000ml

[0028] (2) Preparation method: add boric acid and borax to an appropriate amount of water for injection, heat to dissolve, add gigantol, sodium chloride, and ethyl p-hydroxybenzoate and stir to dissolve, then continue to boil for 15 minutes, stir, mix well, and let cool; Adjust the pH to 6.0-7.0 with borax aqueous solution (1:20), adjust the pH to 6.0-7.0 with sodium chloride, filter and sterilize, add water to the full amount (1000ml), stir well, and make eye drops after filling and sealing.

[0029] (3) Usage and dosage:

[0030] Eye drops, 2-3 times a day, 1-2 drops each time, a course of treatment for 30 days.

example 3

[0031] Example 3 Eye Drops 2

[0032] (1) Prescription:

[0033] Gigantol 1.00g

[0034] Carmellose Sodium 2.0g

[0035] Ethyl p-hydroxybenzoate 0.3g

[0036] Sodium chloride 10.0g

[0037] Add water for injection to 1000ml

[0038] (2) Preparation method:

[0039]Dissolve carmellose sodium in 30% water for injection, dissolve overnight, filter with 200-mesh nylon cloth on a Buchner funnel pad, and set aside; add ethyl p-hydroxybenzoate to a small amount of water, heat to dissolve, and set aside; Add sodium chloride to an appropriate amount of water for injection, heat to dissolve, and set aside.

[0040] Take the above-mentioned carmellose sodium, place it on a water bath, heat and boil, add gigantol under stirring, add ethyl p-hydroxybenzoate solution and sodium chloride solution after stirring evenly, add water for injection to 1000ml, and stir well. Use a 200-mesh nylon cloth pad to filter under reduced pressure on a Buchner funnel, fill it in a container, seal it, ...

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Abstract

The invention relates to a medical preparation containing organic effective constituents, in particular to the application of a compound 3',4-dyhydroxyl-3,5'-dimethoxybibenzyl in preparing medicaments for treating cataract. The compound has double-target inhibition activity, and not only can inhibit the activity of AR to resist high osmotic pressure, but also can inhibit the activity of iNOS to resist oxidation, thus the compound has good effect on resisting the cataract. The compound has small molecules, thereby not only being easy to absorb by the organism, but also being capable of penetrating cell membranes without accumulation effect and toxic and side effects.

Description

technical field [0001] The invention relates to pharmaceutical preparations containing organic active ingredients, in particular to medicines containing bibenzyl compounds. Background technique [0002] Cataract is an eye disease with the highest morbidity and blindness rate in the world. There is no unified understanding of the pathogenic mechanism of cataract, but it is believed that cataract is closely related to lens protein degeneration. Treatments for cataracts include medication and surgery. Surgical treatment has certain risks. First, post-operative wound repair, residual lens epithelial cells (LEC) will rebound and proliferate and migrate, which will form cataract again, that is, "secondary cataract". More and more cataract patients belong to the early stage of development. Or waiting for surgery or the category of unsuccessful surgery; second, some elderly patients are often accompanied by other diseases such as diabetes, hypertension, heart disease, etc. Expens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61P27/12
CPCA61K31/09A61P27/12
Inventor 魏小勇
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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