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Method for improving mouldability and particle quality of traditional Chinese medicine formulation particles obtained by dry granulation

A technology of traditional Chinese medicine formula granules and dry granulation, which can be applied to pharmaceutical formulas, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the differences in physical properties such as maltodextrin compressibility and hygroscopicity. , poor formability, poor solubility and other problems, to improve the spray sticking problem, good fluidity, and enhance the effect of anti-hygroscopicity

Active Publication Date: 2011-05-18
JIANGYIN TIANJIANG PHARMA
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  • Application Information

AI Technical Summary

Problems solved by technology

However, some varieties such as starch, fatty oil, mucus, animal protein and other rhizomes, fruit seeds, and animal Chinese medicine extract powder have problems such as poor formability, poor particle taste, and poor solubility. Therefore, it is necessary to add an appropriate amount when granulating. Excipients improve the aforementioned problems, and at the same time, in order to reduce the dosage and ensure the curative effect, it is required to add as few excipients as possible during granulation, which requires the selection of high-performance excipients that can better improve the granule formability, taste, and solubility
[0004] Maltodextrin is a commonly used excipient in preparations, but few people have noticed that there are significant differences in physical properties such as compressibility and hygroscopicity of maltodextrin in different hydrolysis ranges

Method used

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  • Method for improving mouldability and particle quality of traditional Chinese medicine formulation particles obtained by dry granulation
  • Method for improving mouldability and particle quality of traditional Chinese medicine formulation particles obtained by dry granulation

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Take 1000g of Trichosanthes extract powder, add 250g of maltodextrin with DE value of 20, mix evenly, granulate with roller dry press, and then mix evenly with 2.5g of micropowder silica gel. The one-time molding rate of the granules reaches 68%. The granules have good solubility, good taste, and good anti-moisture agglomeration ability.

Embodiment 2

[0032] Take 1000g of antler concentrate (20% solid content), add 30g each of maltodextrin and lactose with a DE value of 16, mix well, spray dry to obtain antler extract powder, granulate with a roller dry press, and then mix with micropowder Mix 1g of silica gel evenly. The one-time molding rate of the granules is up to 75%, the granules have good solubility, good taste, and good anti-moisture agglomeration ability.

Embodiment 3

[0034] Take 1000g of Morinda officinalis concentrate (solid content 20%), add 60g of maltodextrin with DE value 18 and 40g of maltodextrin with DE value 12, mix well, granulate with roller dry press, and then mix with micro powder Mix 2g of silica gel evenly. The one-time molding rate of the granules reaches 72%. The granules have good solubility, good taste, and good anti-moisture agglomeration ability.

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Abstract

The invention relates to a method for improving mouldability and particle quality of traditional Chinese medicine formulation particles obtained by dry granulation. The method is characterized by comprising: adding maltodextrin with degree of hydrolysis represented by the digestible energy (DE) value of 16-20 before dry granulation; and adding a certain amount of superfine silica powder after particles are granulated, wherein the weight ratio of the maltodextrin with the DE value of 16-20 to total material containing extract powder and all auxiliary materials is (1:0.5)-(1:10), and the superfine silica powder accounts for 0.1-1.5wt% of the granulated particles. By utilizing the method provided by the invention, the mouldability and particle quality of rhizome, fruit seed and animal traditional Chinese medicine formulation particles which are high in contents of fatty oil, animal protein, phlegm and the like and are obtained by dry granulation.

Description

technical field [0001] The invention relates to a method for improving the dry granulation formability and granule quality of traditional Chinese medicine formula granules. It is suitable for varieties with poor viscosity of traditional Chinese medicine extract powder, including rhizomes, fruit seeds and animal Chinese medicine varieties with high content of starch, fatty oil, mucilage, animal protein, etc. It belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Traditional Chinese medicine formula granules are the result of the reform of the dosage form of traditional Chinese medicine decoction pieces. They are made of traditional Chinese medicine decoction pieces as raw materials by extraction, concentration, drying, granulation and other processes. choose. [0003] At present, the granulation process of traditional Chinese medicine formula granules mainly adopts dry granulation. However, some varieties such as starc...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/16A61K47/36
Inventor 陈盛君王玉玺过科家周嘉琳王元清
Owner JIANGYIN TIANJIANG PHARMA
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