Method for measuring liquid level of fermentation tank

A measurement method and fermenter technology, which is applied in the direction of displaying liquid level indicators through pressure measurement, and can solve problems such as increased gas/liquid volume ratio, liquid escape, and increased energy consumption

Active Publication Date: 2011-06-01
HUBEI MAGIC HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there must be foam in aerobic fermentation, and the bubbles in the fermentation liquid rise from the bottom of the fermenter to the top and continue to expand, that is, the gas / liquid volume ratio increases, and the liquid density decreases monotonously; at the same time, the aseptic production conditions in the fermentation process make The above conventional liquid level measurement methods have not been successfully applied to the fermentation process so far
[0006] At present, only the contact electrode method is used to measure the liquid level of fermentation tanks for defoaming in industry. It installs electrodes extending from the top of the tank, and waits for the liquid level to rise to contact the electrodes. This method has some disadvantages. Whether the use of foaming agent is timely and appropriate, and the liquid level cannot be controlled at a reasonable height
Therefore, it is prone to liquid escape, excessive antifoaming agent suppresses the growth of bacteria, and increases the negative factors such as difficulty in extraction and increased energy consumption in the subsequent process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] Embodiment: Take a fermenter with a volume of 57 cubic meters to produce erythromycin as an example.

[0021] The tank body design data of this tank: the height h of the semi-ellipsoidal (axis) section of the lower head at the bottom 0 =0.8m, volume V 0 = 4m 3 ;The middle part of the tank is cylindrical with a height of 6.5 meters and an inner diameter of 3.1m, so the cross-sectional area A is about 7.5m 2 ; The height of the semi-ellipsoid (axis) section of the upper head is 0.8m. According to the fermentation production characteristics of erythromycin, the liquid level is set to be 1.5 meters from the top as the limit of the liquid level rise, that is to say, the liquid level does not exceed 6.6 meters and no liquid escape occurs.

[0022] Install a pressure sensor at the bottom and middle of the fermenter, and pay attention that the two sensors should not be on the same plane as the stirring paddle. The height difference h between the two sensors is 2m, and the s...

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PUM

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Abstract

The invention discloses a method for continuously measuring a liquid level of a fermentation tank. The method is implemented by measuring the average density correction factor k. By using the measurement method, the liquid level height of the fermentation tank and the liquid level variation rate of the fermentation tank can be monitored during the whole course, defoaming can be more scientifically carried out, i.e. a defoamer can be used more properly with less amount, thus no liquid escaping phenomenon is generated, the liquid surface can be in the highest safe height, and the advantages of improving fermentation unit, relieving subsequent extraction process load and providing and reducing energy consumption is obvious.

Description

technical field [0001] The invention belongs to the field of fermentation, and more specifically relates to a method for measuring the liquid level of an aerobic (ventilated) fermentation tank. [0002] Aerobic fermentations must have foam due to aeration. The scope of application of this technology is that the bubbles are evenly distributed into the fermentation liquid, excluding the occasions where the bubbles float on the surface of the liquid and have an obvious gas-liquid interface. Background technique [0003] The liquid level of the fermenter refers to the height of the fermentation liquid in the fermenter. In actual production, due to the change of oxygen supply and ventilation, various liquids are constantly replenished, especially the change (consumption and production) of the fermentation broth composition changes the surface tension of the liquid, and finally changes the gas / liquid volume ratio. As the gas / liquid volume ratio becomes larger, the liquid level i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01F23/14
Inventor 沈家麟齐艳华
Owner HUBEI MAGIC HEALTH TECH CO LTD
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