Penthorum chinense pursh extract and preparation method and application thereof

Abstract

The invention relates to the technical field of medicaments and discloses the novel application of a penthorum chinense pursh extract or compounds of ursolic acid, pinocembrin, scopoletin, gallic acid, ursolic acid-28-xylose-(1-3)-glucoside, pinocembrin-7-glucoside, pinocembrin-7-neohesperidoside, scopolin or galloyl glucoside separated from the penthorum chinense pursh extract. Pharmacological and pharmacodynamic tests show that the penthorum chinense pursh extract or the compounds can obviously reduce the rising of aspartate aminotransferase (AST), glutamic-pyruvic transaminase (ALT) and alkaline phosphatase (ALP), caused by acute liver injury, alcoholic liver and virus hepatitis in mice, chronic hepatic fibrosis in rats and the like, has an obvious inhabitation effect on HepG2 tumor cells and can reduce the cholesterol and triglycercide content of blood serum. The penthorum chinense pursh extract or the compounds are simple in preparation method and low in cost. The invention provides a new medicament source for preventing and treating hepatitides, liver injury, hepatic fibrosis, cirrhosis, alcoholic liver, liver cancer and diseases associated with high blood fat.

Description

A kind of root vegetable extract and its preparation method and application technical field The invention relates to the technical field of medicine, and relates to the use of the extract of the root vegetable or the compound isolated from the extract of the root vegetable in the preparation of drugs for the treatment and prevention of hepatitis, liver injury, liver fibrosis, liver cirrhosis, alcoholic liver, liver cancer and hyperlipidemia Applications. Background technique Penthorum chinense Pursh is a plant belonging to the saxifrage family. It is a traditional medicine of the Miao nationality and has a wide distribution. The whole herb is used as medicine in the folks. The whole plant is warm in nature, sweet in taste, non-toxic, and has the functions of clearing away heat, diuresis, detoxification, promoting blood circulation, calming the liver, strengthening the spleen, and dispelling jaundice. And it also has a certain effect on carbuncle, furunculosis and poisonou...

AI Technical Summary

Problems solved by technology

But so far, there have been no reports of the pharmacological activity of the extract of the root vegetable or the above-mentioned compounds to prevent and treat diseases such as hepatitis, liver injury, liver cirrhosis, hyperlipidemia, and liver cancer.

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