Serial Chinese medicinal preparation for treating phaseolus cold and preparation process and quality control method thereof

A traditional Chinese medicine preparation and a preparation process technology are applied to a series of traditional Chinese medicine preparations for treating colds in four seasons and the fields of preparation technology and quality control thereof, which can solve the problems of loss of volatile oil components, influence on clinical efficacy, low bioavailability, etc. Guaranteed clinical efficacy and high bioavailability

Active Publication Date: 2011-07-06
SHANDONG MINGREN FURUIDA PHARMA
View PDF2 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the research on this variety, we found that: (1) During the production process, the volatile oil was sprayed onto the granules and during the process of low-temperature drying, sub-packaging and other processes, the volatile oil evaporated, and the loss of volatile oil was as high as 20% or more; ( 2) During the storage of the finished product, it has been tested and determined that more than 50% of the volatile oil content of the tablet placed for half a year has been lost; (3) In addition, the continuous escaping of the volatile oil not only affects the curative effect, but also affects the stability of the product. damage (such as oily, pitting, etc.) on the surface of the film
The above conditions have

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Serial Chinese medicinal preparation for treating phaseolus cold and preparation process and quality control method thereof
  • Serial Chinese medicinal preparation for treating phaseolus cold and preparation process and quality control method thereof
  • Serial Chinese medicinal preparation for treating phaseolus cold and preparation process and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Grind 167 parts by weight of bellflower into fine powder; 250 parts by weight of perilla leaves, 167 parts by weight of tangerine peel, and 125 parts by weight of Schizonepeta, add 12 times the amount of water to extract the volatile oil for 3 hours until exhausted, and collect the distilled aqueous solution in another device; Stir the volatile oil distillate with β-cyclodextrin (100ml: 1g) at 40°C for 2 hours to form inclusions; 167 parts by weight of Daqingye, 167 parts by weight of forsythia, 83 parts by weight of licorice, add water and decoct twice , 2 hours each time, the amount of water added is 12 times and 10 times respectively, the decoction is combined, filtered, the filtrate is combined with the above-mentioned distilled aqueous solution, and concentrated into a clear paste with a relative density of 1.32 to 1.36 (measured at 60 to 65°C) Cyperus 167 parts by weight, Fangfeng 125 parts by weight, extracted twice with 60% ethanol, 2 hours for the first time, 1....

Embodiment 2

[0111] Grind 167 parts by weight of bellflower into fine powder; add 250 parts by weight of perilla leaves, 167 parts by weight of tangerine peel, and 125 parts by weight of Schizonepeta, add 12 times the amount of water to extract the volatile oil for 4 hours, and collect the distilled aqueous solution in another device; Stir the volatile oil distillate with β-cyclodextrin (100ml: 6g) at 60°C for 4 hours to form inclusions; 167 parts by weight of Daqingye, 167 parts by weight of forsythia, 83 parts by weight of licorice, add water and decoct twice , 2 hours each time, the amount of water added is 12 times and 10 times respectively, the decoction is combined, filtered, the filtrate is combined with the above-mentioned distilled aqueous solution, and concentrated into a clear paste with a relative density of 1.32 to 1.36 (measured at 60 to 65°C) Cyperus 167 parts by weight, Fangfeng 125 parts by weight, extracted twice with 60% ethanol, 2 hours for the first time, 1.5 hours for ...

Embodiment 3

[0113] Grind 167 parts by weight of bellflower into fine powder; add 250 parts by weight of perilla leaves, 167 parts by weight of tangerine peel, and 125 parts by weight of Schizonepeta, add 12 times the amount of water to extract the volatile oil for 4 hours, and collect the distilled aqueous solution in another device; Take volatile oil, add β-cyclodextrin aqueous solution (4%) (0.3g: 100ml), stir at 60°C for 4h, and form clathrates; parts by weight, add water and decoct twice, each time for 2 hours, the amount of water added is 12 times and 8 times respectively, the decoction is combined, filtered, the filtrate is combined with the above-mentioned distilled aqueous solution, and concentrated to a relative density of 1.32~1.36 (60 ~65 ℃ of clear ointment of measuring); Rhizoma Cyperi 167 parts by weight, Fangfeng 125 parts by weight, extracted twice with 60% ethanol, the first time for 2 hours, the second time for 1.5 hours, the amount of alcohol added was 12 times and 8 tim...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
Login to view more

Abstract

The invention discloses a serial Chinese medicinal preparation for treating phaseolus cold, a preparation process and a quality control method thereof. Preparations are characterized by being prepared from traditional Chinese medicines, namely platycodon root, tangerine peel, indigowoad leaf, weeping forsythiae, nutgrass galingale rhizome, perilla leaf, fineleaf schizonepeta herb, divaricate saposhnikovia root and liquoric root as well as pharmaceutical excipients. The preparation has the effects of clearing away heat and relieving exterior syndromes, and is used for symptoms such as fever and headache, running nose, cough and dry mouth and the like caused by phaseolus cold. Volatile oil is a material base of clearing away heat and relieving exterior syndromes of the preparation; and the traditional preparation process is to adopt a way of spraying the volatile oil into the preparation, and the volatile oil is almost completely lost during the production and storage due to the low content of the volatile oil, so that the clinical therapeutic effect is seriously affected. In the preparation process, a volatile oil inclusion process is adopted, so the loss of the volatile oil during the production and storage is reduced, and the stability of a medicine is improved and the clinical therapeutic effect of the medicine is ensured at the same time. In addition, the more perfect quality control method is used for ensuring the quality; meanwhile, the clinical medication formulation is also enriched, so that the clinical medication demand can be better met.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a series of traditional Chinese medicine preparations for treating colds in four seasons, a preparation process and a quality control method thereof. Background technique [0002] Cold, commonly known as "cold", also known as upper respiratory tract infection, is a common respiratory disease caused by a variety of viruses. May be accompanied by sore throat. Traditional Chinese medicine believes that colds are caused by wind evils attacking the lungs and guards when the human body's ability to resist evils is insufficient. Clinically, two syndromes of wind-cold and wind-heat are the most common. "Siji Ganmao Tablets" is recorded in the thirteenth volume of traditional Chinese medicine prescriptions in the "Drug Standards of the Ministry of Health of the People's Republic of China". Forsythia 167g, licorice (burnt) 83g, Cyperus cyperi (fried) 167g, Fangfeng...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/8905A61K9/20A61K9/48A61P11/00A61P29/00A61P31/12G01N30/90
Inventor 凌沛学张玲贾美春吴维群殷成强赵春荣刘妍妍
Owner SHANDONG MINGREN FURUIDA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products