Serial Chinese medicinal preparation for treating phaseolus cold and preparation process and quality control method thereof

Abstract

The invention discloses a serial Chinese medicinal preparation for treating phaseolus cold, a preparation process and a quality control method thereof. Preparations are characterized by being prepared from traditional Chinese medicines, namely platycodon root, tangerine peel, indigowoad leaf, weeping forsythiae, nutgrass galingale rhizome, perilla leaf, fineleaf schizonepeta herb, divaricate saposhnikovia root and liquoric root as well as pharmaceutical excipients. The preparation has the effects of clearing away heat and relieving exterior syndromes, and is used for symptoms such as fever and headache, running nose, cough and dry mouth and the like caused by phaseolus cold. Volatile oil is a material base of clearing away heat and relieving exterior syndromes of the preparation; and the traditional preparation process is to adopt a way of spraying the volatile oil into the preparation, and the volatile oil is almost completely lost during the production and storage due to the low content of the volatile oil, so that the clinical therapeutic effect is seriously affected. In the preparation process, a volatile oil inclusion process is adopted, so the loss of the volatile oil during the production and storage is reduced, and the stability of a medicine is improved and the clinical therapeutic effect of the medicine is ensured at the same time. In addition, the more perfect quality control method is used for ensuring the quality; meanwhile, the clinical medication formulation is also enriched, so that the clinical medication demand can be better met.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a series of traditional Chinese medicine preparations for treating colds in four seasons, a preparation process and a quality control method thereof. Background technique [0002] Cold, commonly known as "cold", also known as upper respiratory tract infection, is a common respiratory disease caused by a variety of viruses. May be accompanied by sore throat. Traditional Chinese medicine believes that colds are caused by wind evils attacking the lungs and guards when the human body's ability to resist evils is insufficient. Clinically, two syndromes of wind-cold and wind-heat are the most common. "Siji Ganmao Tablets" is recorded in the thirteenth volume of traditional Chinese medicine prescriptions in the "Drug Standards of the Ministry of Health of the People's Republic of China". Forsythia 167g, licorice (burnt) 83g, Cyperus cyperi (fried) 167g, Fangfeng...

AI Technical Summary

Problems solved by technology

During the research on this variety, we found that: (1) During the production process, the volatile oil was sprayed onto the granules and during the process of low-temperature drying, sub-packaging and other processes, the volatile oil evaporated, and the loss of volatile oil was as high as 20% or more; ( 2) During the storage of the finished product, it has been tested and determined that more than 50% of the volatile oil content of the tablet placed for half a year has been lost; (3) In addition, the continuous escaping of the volatile oil not only affects the curative effect, but also affects the stability of the product. damage (such as oily, pitting, etc.) on the surface of the film

The above conditions have seriously affected the clinical efficacy of this product

[0004] In addition, Chinese patent 200410045023.0 discloses a Four Seasons Cold Capsule and its preparation method. It only reforms the dosage form, but the volatile oil used is also sprayed, which also has the disadvantage that the curative effect cannot be well exerted; Chinese patent 200810081948.9 discloses a The Sisimamao Pill is reformed from the Sijimao tablet type. Although its volatile oil is encapsulated by cyclodextrin, compared with tablets and capsules, this type of pill has slower onset of action and lower bioavailability In terms of dosage form selection, patients usually consider fast-acting tablets, capsules, granules and other dosage forms

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