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Catalpol extracting method

An extraction method, the technology of catalpol, applied in the field of extraction of active ingredients of traditional Chinese medicine, can solve the problems of low conversion rate, complicated technical operation, long extraction time, etc., achieve increased yield and output, high product purity, and solve the problems of easy hydrolysis and The effect of oxidation

Inactive Publication Date: 2011-07-20
张守力
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] An object of the present invention is to provide a kind of catalpol with convenient operation, high conversion reliability and high product recovery rate, which can meet the requirements of industrialized production, in order to solve the problems of long extraction time, low conversion rate and complicated technical operation of the above-mentioned prior art. extraction method

Method used

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  • Catalpol extracting method

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) Choose 100kg of fresh rehmannia root, wash and slice, add 0.2kg of compound enzyme solution to enzymolyze for 2 hours by mass, then add 500kg of 75% ethanol, divide into 3 parts, add 1 part after enzymolysis Among the raw materials, homogenate and extract in a homogenate extraction device for 8 minutes at normal temperature, transfer the homogenate, and then add 1 part of the remaining ethanol solution to the homogenized material, repeat the homogenization process, after the homogenization process is completed, Repeat the operation again, after the homogenate is transferred, put it under the action of ultrasonic waves for 15 minutes, combine the homogenate, take the liquid from the filter residue, and concentrate the filtrate under reduced pressure to form a thick extract; 5 kg of thick extract is obtained.

[0026] (2) Dilute the thick extract with 10 kg of water, add it to the macroporous resin soaked in 95% ethanol in advance, pass through the resin, and then elut...

Embodiment 2

[0035] In order to avoid the loss of catalpol, directly elute with 10% ethanol instead of washing with water first, which can increase the yield and improve the purity of the prepared sample. All the other are with embodiment 1. The yield is 370 g, and the product purity is 99.07%.

Embodiment 3

[0037] The enzymolysis solution is composed of cellulase, distiller's yeast, amylase, and acid protease compound enzyme, and the ratio is 1:0.6:0.2:0.3, and the rest are the same as in Example 2. The yield is 365g, and the product purity is 99.12%.

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Abstract

The invention relates to the field of medicine preparation, in particular to a catalpol preparation method, which solves the low conversion rate, low yield and low product quality problems in the preparation of catalpol in the prior art and adopts a process that comprises: washing raw materials, slicing and performing enzymolysis; adding ethanol, performing homogenate extraction for 2 or more times at normal temperature in a homogenate extraction device; mixing homogenate, filtering out slag, collecting filtrate, concentrating the filtrate under reduced pressure, adding water to dilute thick extract, adding the diluted extract into macroporous resin, eluting, and concentrating the eluent under reduced pressure to obtain extract; and adding sample mixing silica gel, uniformly stirring, passing the stirred product through a silica gel column, concentrating eluent under reduced pressure, and recrystallizing in methanol to obtain pure catalpol. The method of the invention greatly improves production efficiency and conversion rate, promotes more effective material in the raw material to be converted into catalpol, further improves product quality, improves product purity and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting effective components of traditional Chinese medicines, in particular to a method for extracting catalpol from rehmannia glutinosa or rehmannia root. Background technique [0002] Catalpol is one of the most important active ingredients of Rehmannia glutinosa, and it is the effective active ingredient of its "nourishing yin" effect. It is an unstable iridoid glycoside compound, often combined with various iridoid glycosides such as Aucubin and berberine exist in plant tissues at the same time, and have various pharmacological activities such as diuresis, laxative, hypoglycemic, liver protection and anti-aging. Studies have shown that catalpol has a significant neuroprotective function in the case of temporary ischemia, and found that catalpol can activate brain neurons, and can treat brain neuropathy caused by trauma, metabolic disorders, cerebral ischemia and Parkinson's disease . [0003] Rehmannia gl...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 张守力
Owner 张守力
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