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Methods and systems for evaluating memory agents

A memory and medicine technology, applied in the field of evaluating memory medicines and systems, can solve problems such as the small effect of PDE inhibitors

Inactive Publication Date: 2011-08-03
DART NEUROSCIENCE CAYMAN LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Third, when this screen was designed, all relevant upstream signaling pathways that could disrupt CREB function during memory formation were unknown
However, in the absence of forskolin-induced AC activation (or neural activity-induced AC activation in vivo), PDE inhibitors alone might be expected to have minimal effect

Method used

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  • Methods and systems for evaluating memory agents
  • Methods and systems for evaluating memory agents
  • Methods and systems for evaluating memory agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0241] Research is conducted to test the effect of the memory agent (HT-0712).

[0242] Six elderly male cynomolgus monkeys (approximately 22 years old at the beginning of the study, which is equivalent to a human age of approximately 66 years old) who were previously trained to complete specific memory tasks were used for the study. Use CANTAB system (Cambridge Neuropsychological Test Automated Battery) and new tasks to evaluate memory performance.

[0243] Discrimination learning-general description of long-term retrieval tasks (DL LTR)

[0244] In this task, animals are provided with 2 pairs of stimuli (for example, 1 pair of shapes and 1 pair of lines) during the daily test. For each pair of stimuli, one stimulus is arbitrarily designated as a positive stimulus (that is, touching the stimulus will be rewarded). Each pair of stimuli is provided 14 times during a daily test period consisting of 28 trials. The paired stimuli (shape or line) are provided in a pseudo-random manner ...

Embodiment 2

[0302] Example 2: Single blind study in healthy elderly individuals

[0303] Research design

[0304] Humans can be used to conduct studies using general protocols and drug administration as described in Example 1. As described below, long-term extraction tasks can utilize face-name pairs and / or occupational pairs of stimuli. The human individual can be shown a face picture as well as the person's name and / or occupation. Occupations can be listed for each name-face pair. In the coding process, human individuals are required to determine whether the name matches the occupation. During the test, the human individual was shown the intact, rearranged and new face-name pair (no occupation provided), and asked to determine that the face-name pair was intact and rearranged Still new. Using this test, human individuals can then be evaluated in the manner described in Example 1.

[0305] In one embodiment, a single-point, double-blind, three-way crossover study was conducted to test th...

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PUM

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Abstract

The present invention provides methods and systems for identifying, evaluating, and testing various compounds as memory agents and regimens as training protocols related to memory enhancement and / or impairment. Such methods and systems may test any compounds or protocols, including the memory agents and training protocols described herein. The methods can comprise combining training protocols with the general administration of memory agents. In some embodiments, the present invention may involve identifying, selecting, testing, evaluating or assessing a compound as a drug candidate for a memory agent, for example, as one effective for enhancing or impairing memory.

Description

[0001] Cross references to related applications [0002] This application claims the priority of U.S. Provisional Application 61 / 081,845 filed on July 18, 2008 in accordance with 35 U.S.C. §119, the entire content of which is incorporated herein by reference in its entirety. Invention field [0003] The present invention relates to methods and systems for evaluating, identifying, or evaluating the effectiveness of memory agents and / or training programs administered to individuals. Background of the invention [0004] Memory is the recollection of past experience. People can record new information, store it, and recall it someday later. The recollection of facts and events represents a conscious and explicit form of memory. People can also remember less conscious skills, such as riding a bicycle, playing a musical instrument, or associations with simple clues about rewards or punishments, which represent more hidden forms of memory. In both cases, the process of memory formation s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/497A61K31/40
CPCA61K31/451A61K31/40A61K31/497A61P25/28C40B30/06G01N33/00G01N33/15
Inventor T·图利L·达瓦契
Owner DART NEUROSCIENCE CAYMAN LTD