Method for preparing micromolecule pectin

A technology of small molecules and pectin, which is applied in the field of high-molecular pectin production technology, and can solve problems such as no control

Active Publication Date: 2013-05-01
SICHUAN YINGRUI PHARMA TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, monosaccharides or disaccharides are usually obtained, and it is basically impossible to prepare 10,000 to 30,000 pectins
[0007] In summary, the current reports all indicate that acid degraded pectin polysaccharides are used to directly or indirectly produce monosaccharides or oligosaccharides, without controlling the process conditions to prepare polysaccharides with a molecular weight of 10,000-30,000 (polymerization degree DP40-135). pectin

Method used

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  • Method for preparing micromolecule pectin
  • Method for preparing micromolecule pectin
  • Method for preparing micromolecule pectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In a 5L three-neck flask, stir mechanically, reflux and condense, add 2.4L formic acid (concentration: 1.098g / mL) at room temperature, add 100g of natural orange peel pectin at room temperature under stirring, dissolve, then heat up to 100°C for 10h. After the reaction, concentrate the solvent, add water to dissolve the residue, adjust the pH to neutral, remove insoluble impurities by suction filtration, and then transfer the filtrate to a membrane filter for treatment with cellulose membranes with a molecular weight cut-off of 30,000 and 10,000, and collect 1 to 3 10,000 molecular weight filtrate, the filtrate was concentrated and dried to obtain 26.0 g of a brown solid, with a yield of 26.0%, a PDI value of 1.66, and a galacturonic acid content of 80.9%.

[0037] The GPC collection of illustrative plates of the pectin that embodiment 1 prepares sees figure 1 . The GPC spectrum shows the molecular weight distribution and molecular weight of the polymer substance. The ...

Embodiment 2

[0039] In a 20L three-neck flask, stir mechanically, reflux and condense, add 12L formic acid (concentration: 1.098g / mL) at room temperature, add 500g of natural orange peel pectin in batches under stirring at room temperature, dissolve, and then heat up to 100°C for 18h. After the reaction, concentrate the solvent, add water to dissolve the residue, adjust the pH to neutral, remove insoluble impurities by suction filtration, and then transfer the filtrate to a membrane filter for treatment with cellulose membranes with a molecular weight cut-off of 30,000 and 10,000, and collect 1 to 3 10,000 molecular weight filtrate, the filtrate was concentrated and dried to obtain 150.0 g of a brown solid, with a yield of 30.0%, a PDI value of 1.96, and a galacturonic acid content of 79.9%.

[0040] The GPC collection of illustrative plates of the pectin that embodiment 2 prepares sees figure 2 . The GPC spectrum shows the molecular weight distribution and molecular weight of the polyme...

Embodiment 3

[0042] In a 2L three-neck flask, stir mechanically, reflux and condense, add 1.2L formic acid (concentration: 1.098g / mL) at room temperature, add 50g of natural orange peel pectin at room temperature under stirring, dissolve, then raise the temperature to 100°C for 3 hours. After the reaction, concentrate the solvent, add water to dissolve the residue, adjust the pH to neutral, remove insoluble impurities by suction filtration, and then transfer the filtrate to a membrane filter for treatment with cellulose membranes with a molecular weight cut-off of 30,000 and 10,000, and collect 1 to 3 10,000 molecular weight filtrate, the filtrate was concentrated and dried to obtain 2.7 g of a brown solid, with a yield of 5.4%, a PDI value of 1.81, and a galacturonic acid content of 79.2%.

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Abstract

The invention relates to a method for preparing micromolecule pectin, belonging to the production technology of macromolecule pectin. The invention provides a method for preparing micromolecule pectin of which the weight-average molecular weight is 10000-30000, the micromolecule pectin is obtained by degrading natural pectin in an acid solution system at the temperature of 55-110DEG C, and the acid solution system is methanoic acid, acetic acid, sulfuric acid or hydrochloric acid aqueous solution. The reaction yield can be 5-30%, the pectin esterification degree is not lowered, and the structure of branched chain heteropolysaccharide is not changed; and the obtained pectin degree of index (PDI) is controlled to 1.6-2.5, i.e. the molecular weight distribution index is lower. The pectin of which the molecular weight is 10000-30000 can serve as a carrier for the in-vivo kidney to excrete and can serve as a polymer drug carrier for intravenous injection.

Description

technical field [0001] The invention relates to a preparation method of small molecular pectin, which belongs to the production process of high molecular pectin. Background technique [0002] Pectin is a kind of natural macromolecular polysaccharide polymer, which represents a group of polysaccharides in the primary cell wall and adjacent cells of higher plants, and also represents a group of complex colloidal polymers prepared from plant materials. Its basic structure is an acidic macromolecular polysaccharide with galacturonic acid as the unit and linked by α-1,4 glycosidic bonds. Its molecule consists of three units to form a helical structure, and the pitch of the helix is ​​1.34nm. structured as figure 1 shown. Among them, galacturonic acid C 6 Many of the carboxyl groups on the product are in the form of methyl esterification, and the residual carboxyl groups that are not methylated exist in the form of free acid or in the form of potassium, sodium, ammonium, and ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/06A61K47/36
Inventor 唐小海冉茂盛邱宇
Owner SICHUAN YINGRUI PHARMA TECH CO
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