Oil-in-water type elsholtzia oil nano emulsion preparation and method for preparing same

An oil-in-water type, fenugreek oil technology, which is applied in the field of medicine, can solve the problems of low solubility of fennel oil, reduce the curative effect of fennel oil, and low bioavailability, achieve good solubilization, and enhance non-specific and specific immunity Function, effect of improving solubility

Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the dissolubility of fennel oil in water is very little, and bioavailability is low, and fennel oil absorbs fast in the body in addition, eliminates fast, thereby has reduced the curative effect of fennel oil

Method used

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  • Oil-in-water type elsholtzia oil nano emulsion preparation and method for preparing same
  • Oil-in-water type elsholtzia oil nano emulsion preparation and method for preparing same
  • Oil-in-water type elsholtzia oil nano emulsion preparation and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Accurately weigh 2.30g of Tween-80, 0.78g of absolute ethanol, 0.30g of liquid paraffin, and 0.05g of fenugreek oil. Stir and mix them well at room temperature of 25°C, then slowly add distilled water to it, adding as you go. Stir, the viscosity of the system is small at the beginning, as the amount of distilled water increases, the system will become viscous, at this time the system may appear liquid crystal state or water-in-oil nanoemulsion, continue to drop and stir continuously, when the system suddenly becomes thinner , what produce this moment is stable yellow transparent oil-in-water type fenugreek oil nanoemulsion, claiming that its gross weight is 10.00g.

Embodiment 2

[0068] Accurately weigh 2.50g of RH-40, 3.00g of EL-40, 2.00g of absolute ethanol, 0.01g of wheat germ oil, and 0.80g of fenugreek oil. Add distilled water and stir while adding. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear in a liquid crystal state or a water-in-oil nanoemulsion. Continue to add drops and keep stirring. When the system suddenly became thinner, what produced now was a stable yellow transparent oil-in-water type fenugreek oil nanoemulsion, and its total weight was 10.00g.

Embodiment 3

[0070] Accurately weigh 3.60g of RH-40, 0.60g of absolute ethanol, 0.60g of 1,2-propanediol, and 1.20g of fenugreek oil, and stir to mix them well at room temperature of 25°C, and then slowly add distilled water to it, while Stir while adding. The viscosity of the system is small at the beginning. With the increase of distilled water, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. When dilute, what produce this moment is stable yellow transparent oil-in-water type fenugreek oil nanoemulsion, claiming that its gross weight is 10.00g.

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Abstract

The invention discloses oil-in-water type elsholtzia oil nano emulsion preparation. The preparation is 10 to 100nm in grain size and consists of the following raw materials in percentage by weight: 23 to 55 percent of surfactant, 7.8 to 20 percent of cosurfactant, 0 to 12 percent of oil, 0.1 to 12 percent of elsholtzia oil and 35 to 68 percent of distilled water. The oil-in-water type elsholtzia oil nano emulsion preparation can improve the solubility of elsholtzia oil, prolong the in vivo metabolism time of elsholtzia oil, improve the bioavailability of elsholtzia oil and enjoy a wide market prospect in medical field.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new drug dosage form of fenugreek oil, which has the effects of sweating and relieving heat, promoting water and dispelling dampness, warming the stomach and regulating the middle, and has broad-spectrum antibacterial and bactericidal effects, and can directly inhibit influenza virus. A transparent and stable oil-in-water type fenugreek oil nanoemulsion preparation and a preparation method thereof. Background technique [0002] Herbs were first recorded in the earliest medical classic "Shen Nong's Herbal Classic" in the Han Dynasty in my country 2,500 years ago. The book says: "Spicy, slightly warm. Indications for cholera, abdominal pain, vomiting, loose edema", and also said: "Sweet-leaves cures summer heat and facilitates urination. The thick decoction is made into ointment and pills, which can be taken to cure water swelling. , curative effect. Indispensable for the treatment of chol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/107A61P1/14A61P31/04A61P31/16A61P43/00
Inventor 欧阳五庆傅晨李雅
Owner NORTHWEST A & F UNIV
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