Gadolinium-gold composite silicone nanomaterial and preparation method and application thereof

A nanomaterial, silicon nanotechnology, applied in the field of medical materials, to achieve the effect of enhancing relaxation rate and enhancing paramagnetism

Inactive Publication Date: 2014-07-02
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Composite materials with gold colloids have not been reported yet.

Method used

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  • Gadolinium-gold composite silicone nanomaterial and preparation method and application thereof
  • Gadolinium-gold composite silicone nanomaterial and preparation method and application thereof
  • Gadolinium-gold composite silicone nanomaterial and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Gd-MCM-41 with 23nm colloidal gold particles was synthesized using cetyltrimethylbromide (CTAB) as a template, tetraethyl orthosilicate as a silicon source, and polyethyleneimine as a polymer modifier.

[0041] Dissolve cetyltrimethylbromide (CTAB) in 80mL of deionized water, add ammonia solution with a mass concentration of 25%, stir and dissolve at room temperature, add polyethylene glycol 4000, continue to stir and dissolve; Ethyl silicate was slowly added dropwise to the above solution, and then GdCl was added under ultrasonic vibration 3 ·6H 2 O, the reaction time is 1.0 h; the solid is collected, washed with absolute ethanol three times, freeze-dried, and calcined at 550° C. for 5.0 h to obtain Gd-MCM-41.

[0042] HAuCl with a mass concentration of 1% 4 Dissolve in 100mL of deionized water, heat to boiling, quickly add 1.5mL of trisodium citrate with a mass concentration of 1%, boil for 10min, leave to cool at room temperature, and obtain colloidal gold particl...

Embodiment 2

[0044] Gd-MCM-41 with 13nm colloidal gold particles was synthesized using cetyltrimethylbromide (CTAB) as a template, tetraethyl orthosilicate as a silicon source, and polyvinylamide as a polymer modifier.

[0045] Dissolve cetyltrimethylbromide (CTAB) in 80mL of deionized water, add ammonia solution with a mass concentration of 25%, stir and dissolve at room temperature, add polyethylene glycol 4000, continue to stir and dissolve; Ethyl silicate was slowly added dropwise to the above solution, and then GdCl was added under ultrasonic vibration 3 ·6H 2 O, the reaction time is 1.0 h; the solid is collected, washed with absolute ethanol three times, freeze-dried, and calcined at 500° C. for 5.0 h to obtain Gd-MCM-41.

[0046] HAuCl with a mass concentration of 1% 4 Dissolve in 100mL of deionized water, heat to boiling, quickly add 10mL of 1% trisodium citrate, boil for 7min, leave to cool at room temperature, and obtain colloidal gold particles with a particle size of 13nm. ...

Embodiment 3

[0048] Using cetyltrimethylbromide (CTAB) as a template, tetraethyl orthosilicate as a silicon source, and polypropylene-methacrylic acid as a polymer modifier to synthesize Gd-MCM-41 with 5nm colloidal gold particles .

[0049] Dissolve cetyltrimethylbromide (CTAB) in 80mL of deionized water, add ammonia solution with a mass concentration of 25%, stir and dissolve at room temperature, add polyethylene glycol 6000, continue to stir and dissolve; Ethyl silicate was slowly added dropwise to the above solution, and then GdCl was added under ultrasonic vibration 3 ·6H 2 O, reaction time 1.0h; collect the solid, wash with absolute ethanol three times, freeze-dry, and calcinate at 450°C for 5.0h to obtain Gd-MCM-41.

[0050] At 4°C, add 1% HAuCl 4 Dissolve in 150mL of deionized water, add 0.4mL of 0.2mol / L K 2 CO 3 solution, adjust the pH to neutral, then add 2.4 mL of 0.5 mg / mL NaBH4 solution prepared with ice water, and stir for 1.0 min to obtain colloidal gold particles wit...

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Abstract

The invention discloses a gadolinium-gold composite silicon nanometer material, a preparation method and application thereof. The gadolinium-gold composite silicon nanometer material of the present invention is composed of silicon oxide, gadolinium and gold, wherein the molar ratios of gadolinium, gold and silicon oxide are 0.01-0.5 respectively. The preparation method of the material is to dissolve the cationic surfactant in water and add it to the alkaline solution, add a solid dispersant and a non-ionic surfactant at the same time, react with ultrasonic oscillation, and then react with tetraethyl orthosilicate and GdCl3·6H2O. Centrifuge, dry, calcinate or wash to obtain gadolinium-doped nanomaterials; the material is dissolved in water, polymer surface modifier and KCl are added, and after a sufficient reaction, it is obtained by dissolving 1% HAuCl4 in deionized water and adding a reducing agent. Colloidal gold particles react together to obtain gadolinium-gold composite silicon nanomaterials. The material can be used to prepare magnetic resonance molecular imaging or optical molecular imaging materials, has strong paramagnetism and tissue T1 and T2 relaxation rates, and has various optical properties.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a gadolinium-gold composite silicon nanomaterial used in magnetic resonance molecular imaging or optical molecular imaging, and a preparation method and application thereof. Background technique [0002] Molecular imaging is an emerging subject based on biology and combined with imaging technology, signal amplification system, medical physics, chemistry, pharmacy, biomathematics and bioinformatics. Qualitative or quantitative research on the pathophysiological process of the living body can be realized from the cellular or molecular level. It uses in vivo imaging technology and non-invasive methods to study the mechanism of diseases from the cellular and molecular levels. In view of the advantages and disadvantages of various medical imaging technologies (fluorescence, radionuclide, MRI, CT) in molecular imaging, through multi-modality imaging methods (multi-modality i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 李立邵元智李幸田秀梅刘桓
Owner SUN YAT SEN UNIV
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