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Green extraction process for artemisinin

An extraction process, artemisinin technology, applied in the direction of organic chemistry, can solve the problems of no market competitiveness, high operating costs, low production capacity, etc., to delay the decline of artemisinin content, reduce production costs, and improve the extraction rate Improved effect

Active Publication Date: 2013-02-13
GUANGXI XIANCAOTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After entering the 1990s, supercritical carbon dioxide extraction technology began to be used to extract medicinal active ingredients from medicinal plants. It is reported that my country has also studied the supercritical fluid extraction of artemisinin, but in the end, this method has a large investment in equipment and production. The shortcomings of low capacity, high operating costs, and lack of market competitiveness have not yet carried out large-scale industrial production at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The artemisinin green extraction process of the present invention comprises the following steps:

[0026] (1) Raw material drying treatment: The raw materials of Artemisia annua (the raw material of Artemisia annua is the directly purchased medicinal plant Artemisia annua, with a water content of 14%) are put into microwave energy-saving drying equipment for drying treatment. During the drying process, microwave energy-saving drying equipment The temperature is set to 45°C, and the drying time is 30 minutes. When the moisture of the raw materials of Artemisia annua drops to 7%, the raw materials of Artemisia annua are taken out and bagged, and stored in storage;

[0027](2) Primary preparation of artemisinin: put 1000kg of the dried artemisinin raw material in step (1) into the extraction tank, close the feeding port of the extraction tank, open the oil inlet valve of the extraction tank, and add petroleum into the extraction tank Ether, heating countercurrent extractio...

Embodiment 2

[0045] The technological process of the present embodiment is the same as that of the first embodiment, and only part of the technological parameters are different. The artemisinin green extraction process of the present invention includes the following steps:

[0046] (1) Raw material drying treatment: put the raw materials of Artemisia annua into the microwave energy-saving drying equipment for drying treatment. During the drying process, the temperature of the microwave energy-saving drying equipment is set to 60°C, and the drying treatment time is 35 minutes, until the moisture of the raw materials of Artemisia annua drops to 60°C. At 6%, take out the raw materials of Artemisia annua, pack them in bags, and store them in storage;

[0047] (2) Primary preparation of artemisinin: (1) 1000kg of the dried artemisinin raw material was put into the extraction tank, the feeding port of the extraction tank was closed, the oil inlet valve of the extraction tank was opened, and petro...

Embodiment 3

[0052] The technological process of the present embodiment is the same as that of the first embodiment, and only part of the technological parameters are different. The artemisinin green extraction process of the present invention includes the following steps:

[0053] (1) Raw material drying treatment: put the raw materials of Artemisia annua into the microwave energy-saving drying equipment for drying treatment. During the drying process, the temperature of the microwave energy-saving drying equipment is set to 65°C, and the drying treatment time is 25 minutes, until the moisture of the raw materials of Artemisia annua drops to 65°C. At 5%, take out the raw materials of Artemisia annua, pack them in bags, and store them in storage;

[0054] (2) Primary preparation of artemisinin: (1) 1000kg of the dried artemisinin raw material was put into the extraction tank, the feeding port of the extraction tank was closed, the oil inlet valve of the extraction tank was opened, and petro...

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Abstract

The green artemisinin extraction process of the present invention relates to the field of pharmaceutical production, and the extraction process includes the following steps: (1) raw material drying treatment: putting the raw material into drying equipment for drying treatment; (2) initial preparation of artemisinin: Put the dried raw material into the extraction tank, add petroleum ether, heat countercurrent extraction, release the countercurrent extraction solution from the extraction tank, let the countercurrent extraction solution stand still, take the supernatant and let it pass through the silica gel column, and then elute with petroleum ether Silica gel column, collect artemisinin-containing fractions and concentrate them in a concentration tank. When crystals are precipitated in the concentration tank, put the concentrated solution in a crystallization tank for crystallization, filter out the crystals, and dry the crystals to obtain crude artemisinin; (3) Refining of artemisinin: Put the crude artemisinin in an alcohol precipitation tank, dissolve it with 65-75 times 93-95% ethanol and let it stand still, take the supernatant and filter it finely, put the filtrate in a concentration tank to concentrate and let it stand still Place crystals, filter out the crystals, and vacuum dry the crystals to obtain fine artemisinin.

Description

Technical field [0001] The invention involves the field of drug production, especially a extract of artemisinin. Background technique [0002] Artemisin is an artemisinin drug extracted from the medicinal plant of ARTemisia Annua L., which is a semi -semi -saloneine compound containing the peroxide group.The Chinese herbal medicine extract developed by Western medicine is the World Health Organization (WHO) clearly stipulating the replacement of Queen's antimalarial materials.The production and sales of artemisinin in my country accounted for more than 90%of global production and sales, and China's extraction technology represents the world level. [0003] At present, the process of extracting artemisinin in domestic Huanghua Artemisiahin is mainly the traditional organic solution extraction separation method, that is, the use of organic solvents such as ethanol, acetone, gasoline, etc. to extract the extraction solution, and then pass through large pore resin or through large ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/20
Inventor 黄盛群刘无垢黄宗延覃华兴孔雪萍
Owner GUANGXI XIANCAOTANG PHARMA
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