Green extraction process for artemisinin

Abstract

The green artemisinin extraction process of the present invention relates to the field of pharmaceutical production, and the extraction process includes the following steps: (1) raw material drying treatment: putting the raw material into drying equipment for drying treatment; (2) initial preparation of artemisinin: Put the dried raw material into the extraction tank, add petroleum ether, heat countercurrent extraction, release the countercurrent extraction solution from the extraction tank, let the countercurrent extraction solution stand still, take the supernatant and let it pass through the silica gel column, and then elute with petroleum ether Silica gel column, collect artemisinin-containing fractions and concentrate them in a concentration tank. When crystals are precipitated in the concentration tank, put the concentrated solution in a crystallization tank for crystallization, filter out the crystals, and dry the crystals to obtain crude artemisinin; (3) Refining of artemisinin: Put the crude artemisinin in an alcohol precipitation tank, dissolve it with 65-75 times 93-95% ethanol and let it stand still, take the supernatant and filter it finely, put the filtrate in a concentration tank to concentrate and let it stand still Place crystals, filter out the crystals, and vacuum dry the crystals to obtain fine artemisinin.

Description

Technical field

[0001] The invention involves the field of drug production, especially a extract of artemisinin. Background technique

[0002] Artemisin is an artemisinin drug extracted from the medicinal plant of ARTemisia Annua L., which is a semi -semi -saloneine compound containing the peroxide group.The Chinese herbal medicine extract developed by Western medicine is the World Health Organization (WHO) clearly stipulating the replacement of Queen's antimalarial materials.The production and sales of artemisinin in my country accounted for more than 90%of global production and sales, and China's extraction technology represents the world level.

[0003] At present, the process of extracting artemisinin in domestic Huanghua Artemisiahin is mainly the traditional organic solution extraction separation method, that is, the use of organic solvents such as ethanol, acetone, gasoline, etc. to extract the extraction solution, and then pass through large pore resin or through large ho...