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Ligands for aggregated tau molecules

A helical, self-contained technique in the field of ligands for neuropathic staging

Active Publication Date: 2011-10-19
WISTA LAB LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

EEG-neurological diagnostic methods have been developed (see e.g. Vargha-Khadem, F. et al. (1997); Willingham, D.B. (1997); Lakmache, Y. et al. (1995); and Hodges, J.R. et al. (1999) ), but there is still a need in this regard for inexpensive instrumentation available in contact with the clinician

Method used

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  • Ligands for aggregated tau molecules
  • Ligands for aggregated tau molecules
  • Ligands for aggregated tau molecules

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[0828] In one embodiment, the compound is selected from compounds of the following formulae and pharmaceutically acceptable salts, hydrates and solvates thereof.

[0829] Compounds, wherein -Q- is -NHC(O)-; -NR 1 C(O)-; -C(O)NH-; or -C(O)NR 1 -.

[0830] Benzothiazole compounds

[0831] Non-fluorinated methoxy-amides

[0832]

[0833]

[0834]

[0835] In one embodiment, the compounds are independently selected from:

[0836] ABMA-04; ABMA-05; ABMA-06; ABMA-07; ABMA-08; ABMA-09; ABMA-10; ABMA-11; ABMA-13; ABMA-14; ABMA-15; and ABMA-16.

[0837] In one embodiment, the compounds are independently selected from:

[0838] ABMA-04; ABMA-05; ABMA-06; ABMA-07; ABMA-08; ABMA-09; ABMA-10; ABMA-11; and ABMA-13.

[0839] Fluorinated methoxy-amide

[0840]

[0841]

[0842]

[0843] In one embodiment, the compounds are independently selected from:

[0844] ABFMA-04; ABFMA-05; ABFMA-06; ABFMA-07; ABFMA-08; ABFMA-09; ABFMA-11; ABFMA-12; ABFMA-14; ABFMA-15;

[08...

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Abstract

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example:formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Description

[0001] related application [0002] This application claims priority from US 61 / 099,376, filed September 23, 2008, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention generally relates to materials, methods and models related to the labeling and detection of neurofibrillary tangles. Furthermore, the present invention relates to ligands suitable for neuropathological staging and their use in the diagnosis, prediction or treatment of diseases such as Alzheimer's disease (AD). Background technique [0004] In order to more fully describe and fully disclose this invention and the state of the art related to this invention, this application refers to various patents and publications. Each reference is incorporated into this specification by reference in its entirety, and each reference should be deemed to be individually and specifically incorporated by reference. [0005] Throughout this specification (in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C07D275/04C07D277/66C07D279/06
CPCC07D277/66C07D417/12C07D471/04C07D487/04C07D513/04G01N2333/4709G01N2800/2821G01N33/6896Y10T436/17Y10T436/18Y10T436/147777Y10T436/14
Inventor 史蒂文·J·凯姆普琳达·J·斯托里约翰·M·D·斯托里詹内特·里卡德查尔斯·R·哈林顿克劳德·M·维希克斯科特·克鲁纳斯托拜厄斯·K·海因里克
Owner WISTA LAB LTD
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