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Crocodile Scale Extract and Its Application

A technology of extract and crocodile scale, applied in crocodile scale extract and its application field, can solve problems such as not yet seen

Active Publication Date: 2011-12-07
许瑞安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Crocodile Scale Extract and Its Application
  • Crocodile Scale Extract and Its Application
  • Crocodile Scale Extract and Its Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0180] "Example 1" crocodile scale extract

[0181] The crocodile scale extract of the present invention is prepared through the following method:

[0182] Weigh 1 g of crocodile scale powder, add 10 mL of distilled water, boil and reflux for extraction for 2 h, centrifuge at 8000 r / min for 10 min, take the supernatant, adjust the pH to 7, and prepare a crude extract with a crude drug concentration of 0.1 g / mL. Filter through 0.45 μm and 0.22 μm microporous membranes, sterilize, and store in aliquots.

[0183] Wherein, the crocodile scale powder technique can be purchased from the market, and the crocodile scale capsule used in the present invention comes from Sriracha Dragon Tiger Garden in Thailand.

Embodiment 2

[0184] 《Example 2》Pharmaceutical composition

[0185] A pharmaceutical composition comprises crocodile scale extract and other pharmaceutically acceptable carriers. Its weight ratio is 1-99%: 1-99%. The pharmaceutical composition can be prepared into any pharmaceutically acceptable dosage form. Such as: tablets, granules, injections, etc.

Embodiment 3

[0186] "Example 3" application of pharmaceutical composition

[0187] The pharmaceutical composition described in Example 2 has a good effect on treating liver fibrosis.

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Abstract

The invention relates to a crocodile scale extract and application thereof. A preparation method for the crocodile scale extract comprises the following steps of: adding crocodile scales into water, boiling, centrifuging, extracting supernate, and regulating the pH value to prepare the crocodile scale extract. The invention provides a crocodile scale extract and application of the crocodile scaleextract to the preparation of medicaments for treating hepatic fibrosis.

Description

Technical field: [0001] The invention belongs to the field of pharmacy, and relates to a crocodile scale extract and its application. Background technique: [0002] Hepatic fibrosis (HF) is the activation of Kupffer cells ( KC), secrete a variety of cytokines, together with platelets, cytokines secreted by liver sinusoidal endothelial cells (SEC) and some chemical mediators to activate hepatic stellate cells (HSC) to transform into liver fibroblasts (MFB), Through paracrine and autocrine effects, a large amount of collagen-based extracellular matrix (ECM) is produced, causing excessive deposition of ECM in the liver, leading to the generation and development of liver fibrosis. Liver fibrosis is the early stage and necessary stage of liver cirrhosis, which can be reversed under certain circumstances. However, if the cause persists, liver fibrosis will gradually increase, liver lobules and blood vessels will be gradually remodeled, and the normal structure of the liver will b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P1/16A61K35/58
Inventor 许瑞安王晓崔秀灵
Owner 许瑞安
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