Application of golden belt in preparation of medicine for treating acute spinal cord injury

A technology for spinal cord injury and golden belt, applied in the field of golden belt, can solve the problem of up-regulation of BDNF gene expression

Inactive Publication Date: 2011-12-07
玉溪市中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another possibility is that neurons synthesize themselves. Although the expression level of BDNF in the spinal cord is low under normal conditions, the expression of BDNF gene may be significantly up-regulated after injury.

Method used

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  • Application of golden belt in preparation of medicine for treating acute spinal cord injury
  • Application of golden belt in preparation of medicine for treating acute spinal cord injury
  • Application of golden belt in preparation of medicine for treating acute spinal cord injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] (1) Soak Daphne genkwa root in clean water for 7 days, peel off the root bark, remove the woody core and impurities, wash it, dry it in the sun, and break it into small pieces with a diameter of about 1 square centimeter;

[0106] (2) Get 1800 grams of above-mentioned genkwa roots and put them into a container, add 8000 milliliters of ethanol with a concentration of 60% in the container, extract for 1 hour with the reflux extraction method, and obtain an ethanol extract, and the described reflux extraction method is as follows: Heating and distilling the leaching solution of Daphne genkwa root in ethanol, wherein the volatile solvent is distilled off and then cooled, and after the dregs are discarded, it is repeatedly flowed back into the leaching container to extract the raw material of Daphne genkwa root, and so on, until the active ingredients are refluxed and extracted completely;

[0107] (3) Get the following raw materials in parts by weight: 400 grams of water-so...

Embodiment 2

[0110] (1) Soak Daphne genkwa root in clean water for 7 days, peel off the root bark, remove the woody core and impurities, wash it, dry it in the sun, and break it into small pieces with a diameter of about 1 square centimeter;

[0111] (2) Get 900 grams of above-mentioned Daphne genkwa roots, add 4000 milliliters of ethanol with a concentration of 60%, extract for 1 hour with the reflux extraction method, remove the slag and retain the liquid, and obtain the ethanol extract;

[0112] (3) Take the following raw materials in parts by weight: 200 grams of water-soluble dextrin, 200 grams of starch; uniformly mix the above-mentioned raw materials to obtain 400 grams of absorbent;

[0113] (4) Get above 200 grams of absorbents and join in the ethanol extract that step (2) makes, make clear paste material, put clear paste material in drying box and dry at low temperature, collect in dry thing and grind into 260 gram of fine powder, and then add 40 grams of absorbent to a total wei...

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PUM

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Abstract

The invention relates to an application of winter jasmine in preparing medicines for treating acute spinal cord injury (SCI), and particularly relates to a novel application of winter jasmine in the pharmaceutical field. In the treatment of acute SCI, winter jasmine has the advantages of definite and effective curative effect, low toxic and adverse effects and high safety. In the treatment of SCI, winter jasmine can up-regulate the expression of BDNF (Brain-derived neurotrophic factor) while down-regulating the expression of NMDA (N-methyl-D-aspartate) receptor, and can effectively improve the movement function of SCI rats.

Description

technical field [0001] The invention relates to the application of a gold belt, in particular to the application of a gold belt in the pharmaceutical field. Background technique [0002] The golden belt is the processed product of the root bark of the Daphne genkia plant, that is, the product of the genkwa root, which is commonly known as "thief medicine" among the people. [0003] Daphne genkwagen, English name: Root of Lilac Daphne, aliases: yellow euphorbia, golden belt, Shu mulberry, iron cowhide, puffy grass; Latin plant animal mineral name: Daphne genkwa Sieb.et Zucc. Daphne genkwa root is pungent; bitter; warm in nature; poisonous; returns to the lung; spleen; liver; kidney meridian; functions to expel water; detoxify; resolve stagnation. Indicates edema; scrofula; breast abscess; hemorrhoids; scabies; rheumatic arthralgia; usage and dosage: oral administration: decoction, 1.5-4.5g; smashed into juice or into pills, powder. External application: appropriate amount, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61P25/00
Inventor 许争光
Owner 玉溪市中医医院
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