Coenzyme Q-10/EGF liposome, preparation method and application

A liposome and coenzyme technology, applied in the fields of skin care products, pharmaceutical preparations and cosmetics, can solve the problems of particle aggregation, drug leakage, liposome instability, etc., and achieves a simple preparation method, anti-aging skin repair, reducing system stable effect

Active Publication Date: 2012-01-04
GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for different target drugs, it is necessary to select a suitable lipid material and molding process to obtain a satisfactory liposome-encapsulated drug, otherwise liposome instability, drug leakage or particle aggregation will easily occur.
[0008] At present, there is no relevant research report on the combination of coenzyme Q-10 and EGF for the preparation of cosmetics and skin care products, and there is no combination of liposome encapsulation technology, coenzyme Q-10 and EGF for cosmetics and skin care products. Prepared related research reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0035] Coenzyme Q-10 2.5 parts;

[0036] EGF 7.5 parts;

[0037] Cholesterol 10 parts;

[0038] Lecithin 80 parts;

[0039] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0040] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0041] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0042] Cholesterol, lecithin, coenzyme Q-10 and EGF are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then ice water is added to the nanoemulsion to obtain a nanoemulsion. Aqueous suspension, and finally obtain the required coenzyme Q-10 / EGF liposo...

Embodiment 2

[0045] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0046] Coenzyme Q-10 5 parts;

[0047] EGF 4.5 parts;

[0048] Cholesterol 25 parts;

[0049] Lecithin 65 parts;

[0050] Vitamin E 0.5 parts.

[0051] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0052] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0053] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0054] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the d...

Embodiment 3

[0057] The coenzyme Q-10 / EGF liposome of the present embodiment is made up of the following components in parts by weight:

[0058] Coenzyme Q-10 5.5 parts;

[0059] EGF 6.3 parts;

[0060] Cholesterol 30 parts;

[0061] Lecithin 58 parts;

[0062] Vitamin E 0.2 parts.

[0063] The average particle diameter of the coenzyme Q-10 / EGF liposome is 150-200 nm.

[0064] The above-mentioned cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are all commercially available pure products.

[0065] The preparation method of the present embodiment coenzyme Q-10 / EGF liposome, its specific steps are as follows:

[0066] Cholesterol, lecithin, coenzyme Q-10, EGF and vitamin E are added into an organic solvent and fully dissolved to obtain a mixed solution. The mixed solution is passed through nitrogen while rotating to evaporate the organic solvent to obtain a nanoemulsion, and then add ice to the nanoemulsion. Sonicate water to obtain an aqueous suspension, and finally obtain the...

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Abstract

The invention discloses coenzyme Q-10 / EGF liposome, a preparation method and application. The coenzyme Q-10 / EGF liposome consists of the following components in part by weight: 2.5 to 6 parts of coenzyme Q-10, 3 to 7.5 parts of epidermal growth factor (EGF), 10 to 30 parts of cholesterol, 50 to 80 parts of lecithin and 0 to 0.5 part of vitamin E. According to the coenzyme Q-10 / EGF liposome, phospholipid bi-layer is used as a carrier material, the coenzyme Q-10 and the EGF can automatically coated in the phospholipid bi-layer, so that excipient and plasticizer are avoided; the preparation method is simple; and the coenzyme Q-10 and the EGF have good stability. The coenzyme Q-10 / EGF liposome has remarkable effects of skin aging resistance and repair, and does not destroy the system stability of cosmetics or health-care products when used in the cosmetics or the health-care products; and due to the structure of the liposome, the coenzyme Q-10 and the EGF can be better absorbed by the skin.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations, cosmetics and skin care products, in particular to the application of the combination of coenzyme Q-10, EGF and liposome encapsulation technology in cosmetics and skin care products. Background technique [0002] With the gradual aging of our society, anti-aging beauty and skin care are getting more and more attention. [0003] Coenzyme Q-10 is a very small amount of substances necessary for life activities that are ubiquitous in human and animal organs and tissues. Coenzyme Q-10 has anti-aging, cardiovascular disease prevention, anti-tumor, immune regulation, anti-skin wrinkle and The efficacy of delaying skin aging and other aspects has been confirmed. [0004] EGF (Epidermal Growth Factor) is an active substance in the human body. It is a living cell composed of 53 amino groups. It has a significant effect on shrinking pores and anti-wrinkle. The reason is that EGF can promote the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/35A61K8/14A61Q19/08
Inventor 方永生
Owner GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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