Composite preparation and preparing method thereof

A technology of compound preparations and active ingredients, which is applied in the field of medicine and can solve problems such as the uncertainty of the exact relationship

Inactive Publication Date: 2012-01-11
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The occurrence of BPH is affected by many factors, such as smoking, obesity, drinking, race, genetics, hypertension, diabetes, sex life, socioeconomic status, etc. Although there are many studies on various factors, they are related to the occurrence of BPH Exact relationship still undetermined

Method used

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  • Composite preparation and preparing method thereof
  • Composite preparation and preparing method thereof
  • Composite preparation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Compound Tamsulosin Dutasteride Capsules

[0018] prescription:

[0019] Dutasteride fraction:

[0020]

[0021] Capsule shell part:

[0022]

[0023] Process:

[0024] 1. Get gelatin, glycerin, titanium dioxide, iron oxide (yellow) purified water, heat on a water bath to melt, and stir evenly, with medium-chain triglycerides and medium-chain triglycerides containing lecithin (0.3%) as Lubricant, for the preparation of soft capsule shells.

[0025] 2. Take caprylic capric acid glyceride and heat it to 40°C on a water bath, and fill the container with nitrogen for the next step. Add BHT and dutasteride to dissolve completely and become a homogeneous transparent liquid. Cool to 25°C-33°C. Filter and set aside.

[0026] 3. Prepare drug-loaded soft capsules with the above-mentioned capsule material and medicinal solution. About 66mg in each capsule shell, its content weighs about 100mg. Obtain drug-loaded dutasteride soft capsules.

[0027] Tamsulos...

Embodiment 2

[0034] Example 2 Compound Tamsulosin Dutasteride Capsules

[0035] prescription:

[0036] Dutasteride fraction:

[0037]

[0038] Capsule shell part:

[0039]

[0040] Process:

[0041] 1. Get gelatin, glycerin, titanium dioxide, iron oxide (yellow) purified water, heat on a water bath to melt, and stir evenly, with medium-chain triglycerides and medium-chain triglycerides containing lecithin (0.3%) as Lubricant, for the preparation of soft capsule shells.

[0042] 2. Take caprylic capric acid glyceride and heat it to 40°C on a water bath, and fill the container with nitrogen for the next step. Add BHT and dutasteride to dissolve completely and become a homogeneous transparent liquid. Cool to 25°C-33°C. Filter and set aside.

[0043] 3. Prepare drug-loaded soft capsules with the above-mentioned capsule material and medicinal solution. About 66mg in each capsule shell, its content weighs about 100mg. Obtain drug-loaded dutasteride soft capsules.

[0044] Tamsulos...

Embodiment 3

[0051] Example 3 Compound Tamsulosin Dutasteride Capsules

[0052]prescription:

[0053] Dutasteride fraction:

[0054]

[0055] Capsule shell part:

[0056]

[0057] Process:

[0058] 1. Get gelatin, glycerin, titanium dioxide, iron oxide (yellow) purified water, heat on a water bath to melt, and stir evenly, with medium-chain triglycerides and medium-chain triglycerides containing lecithin (0.3%) as Lubricant, for the preparation of soft capsule shells.

[0059] 2. Take caprylic capric acid glyceride and heat it to 40°C on a water bath, and fill the container with nitrogen for the next step. Add BHT and dutasteride to dissolve completely and form a homogeneous transparent liquid. Cool to 25°C-33°C. Filter and set aside.

[0060] 3. Prepare drug-loaded soft capsules with the above-mentioned capsule material and medicinal solution. About 66mg in each capsule shell, its content weighs about 100mg. Obtain drug-loaded dutasteride soft capsules.

[0061] Tamsulosin ...

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PUM

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Abstract

The invention relates to a composite preparation, and preparing method and use thereof. The composite preparation uses Tamsulosin and Dutasteride as active ingredients, wherein Tamsulosin is in the form of enteric pellet, granule or tablet, Dutasteride is in the form of soft capsule, and both of them are filled in a hard capsule. The invention discloses a preparing method of the composite preparation.

Description

technical field [0001] The invention relates to a compound preparation and a preparation method, belonging to the technical field of medicine. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common disease in elderly men, and its incidence increases with age, but there may not be clinical symptoms when there are hyperplasia lesions. The occurrence of BPH is affected by many factors, such as smoking, obesity, drinking, race, genetics, hypertension, diabetes, sex life, socioeconomic status, etc. Although there are many studies on various factors, they are related to the occurrence of BPH The exact relationship has yet to be determined. The incidence of BPH mainly comes from autopsy data, 40% of men aged 50, and 90% of men aged 80 have BPI-I histological changes. In the United States, about 1.7 million BPH patients go to outpatient clinics every year, about 300,000 people undergo prostate surgery, and about 2 billion U.S. dollars are lost each year due t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/48A61P13/08A61P13/00A61K31/18A61K31/205
Inventor 不公告发明人
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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